LEADER 05294nam 2200673 a 450 001 9910826161303321 005 20240516143633.0 010 $a6613556491 010 $a1-280-37858-1 010 $a9786613556493 010 $a1-61499-024-7 035 $a(CKB)2670000000173995 035 $a(EBL)888744 035 $a(OCoLC)785811759 035 $a(SSID)ssj0000659198 035 $a(PQKBManifestationID)12249291 035 $a(PQKBTitleCode)TC0000659198 035 $a(PQKBWorkID)10694945 035 $a(PQKB)10178047 035 $a(MiAaPQ)EBC888744 035 $a(Au-PeEL)EBL888744 035 $a(CaPaEBR)ebr10551713 035 $a(CaONFJC)MIL355649 035 $a(EXLCZ)992670000000173995 100 $a20120302d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTranslational pathology of early cancer$b[electronic resource] /$fedited by Sudhir Srivastava and William E. Grizzle 205 $a1st ed. 210 $aAmsterdam ;$aWashington, D.C. $cIOS Press$dc2012 215 $a1 online resource (562 p.) 300 $aDescription based upon print version of record. 311 $a1-61499-023-9 320 $aIncludes bibliographical references and indexes. 327 $aTitle Page; Contents; Editorial - Translational Pathology of Early Cancer; Scientific Concepts, Pathology and Genetics of Early Cancer; Translational Pathology of Neoplasia; The Biology of Incipient, Pre-Invasive or Intraepithelial Neoplasia; Biomarkers and the Genetics of Early Neoplastic Lesions; Cancer Stem Cells and Markers: New Model of Tumorigenesis with Therapeutic Implications; DNA Methylation in Early Neoplasia; Molecular Cytogenetic Evidence for Multistep Tumorigenesis: Implications for Risk Assessment and Early Detection 327 $aNoncoding RNAs in Molecular Characterization of Cancer PreneoplasiaStromal-Epithelial Interactions in Early Neoplasia; Molecular Pathology; Molecular Pathology and Biomarkers of Bladder Cancer; Biologic Characteristics of Premalignant Breast Disease; Central Nervous System; Molecular and Genetic Basis of Childhood Cancer; Development and Progression of Colorectal Neoplasia; The Molecular Pathology of Cutaneous Melanoma; Molecular Pathogenesis of Endometrial and Ovarian Cancer; Early Events During Neoplastic Progression in Barrett's Esophagus 327 $aMolecular Changes in the Multistage Pathogenesis of Head and Neck CancerPathogenesis of Early Leukemia and Lymphoma; Hepatocellular Carcinoma of the Liver; Preneoplasia of Lung Cancer; Micrometastasis: Detection Methods and Clinical Importance; Molecular Pathology of Early Pancreatic Cancer; Molecular Pathology of Prostate Cancer; Renal Cell Carcinoma; The Molecular Pathology of Sarcomas; Stomach - Genetic and Epigenetic Alterations of Preneoplastic and Neoplastic Lesions; Enabling Resources; Bioinformatics: Biomarkers of Early Detection 327 $aIssues in Collecting, Processing and Storing Human Tissues and Associated Information to Support Biomedical ResearchAuthor Index; Subject Index 330 $aThe visual pathologic features of tumors have always been the critical parameters in determining tumor type; however, over the last several decades molecular analysis of tumors has played an increasing role in the diagnostic pathology of tumors; thus, "molecular pathology" has gradually emerged as a discipline in pathology which exploits the use of nucleic acid based techniques. The purpose of this Handbook is to discuss the principles and the application of selected existing methods of molecular pathology and its use in the detection of early cancer. It will describe the molecular changes that characterize preinvasive neoplastic lesions, molecular targets for early detection, validation of molecular targets and areas of new diagnostic technology that show promise either for early detection of neoplasias or other medically important uses in cancer prevention and care. The book describes recent advances in proteomics, metabolomics, stem cells research, micro RNA and other posttranslational molecular modifications; all these will serve the pressing needs in the development of the practice of personalized medicine.The book is divided into three sections that follow a sequence from basic mechanisms of tumor development, through the molecular and biological abnormalities found in common types of cancers, to the technologies which are most applicable to detecting these biologic alterations in precancerous lesions. Each chapter discusses the scientific underpinnings of the evolution and progression of tumors in order to enable clinicians and other professionals who manage cancer patients to better understand the disease at the molecular and genetic levels. 606 $aCancer 606 $aTumors 606 $aCarcinogenesis 615 0$aCancer. 615 0$aTumors. 615 0$aCarcinogenesis. 676 $a616.9 676 $a616.9/101 701 $aSrivastava$b Sudhir$01150035 701 $aGrizzle$b William E$01651067 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910826161303321 996 $aTranslational pathology of early cancer$94000794 997 $aUNINA