LEADER 05311nam 2200661 a 450 001 9910825989503321 005 20240313133504.0 010 $a1-118-52215-X 010 $a1-299-14624-4 010 $a1-118-52213-3 010 $a1-118-52212-5 035 $a(CKB)2670000000325662 035 $a(EBL)1115560 035 $a(SSID)ssj0000819738 035 $a(PQKBManifestationID)11410958 035 $a(PQKBTitleCode)TC0000819738 035 $a(PQKBWorkID)10863770 035 $a(PQKB)11651825 035 $a(MiAaPQ)EBC1115560 035 $a(Au-PeEL)EBL1115560 035 $a(CaPaEBR)ebr10650027 035 $a(CaONFJC)MIL445874 035 $a(OCoLC)827208571 035 $a(PPN)178197432 035 $a(EXLCZ)992670000000325662 100 $a20121120d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEquine genomics /$feditor, Bhanu P. Chowdhary 205 $a1st ed. 210 $aAmes, Iowa $cWiley-Blackwell$d2013 215 $a1 online resource (346 p.) 300 $aDescription based upon print version of record. 311 $a0-8138-1563-0 320 $aIncludes bibliographical references and index. 327 $aEquine Genomics; Contents; Contributors; Preface; 1 Defining the equine genome: The nuclear genome and the mitochondrial genome; Nuclear Genome of the Horse; Chromosome number, karyotype, and schematic presentation; Application of different banding techniques; Chromosome aberrations - a brief overview; Mitochondrial Genome of the Horse; Structure, function, and utility; Phylogenetics of Equus; New research directions; Acknowledgments; References; 2 Genetic linkage maps; Introduction; Genetic Linkage Maps; Polymorphic Genetic Markers; Reference Pedigrees; Horse Genetic Linkage Maps 327 $aThe Uppsala mapThe International Horse Reference Family Panel (IHRFP) map; The Newmarket map; The International Equine Gene Mapping Workshop (IEGMW) linkage map; the merging of contemporary linkage maps; The Selection of Microsatellite Mapping Panels for the Dissection of Inherited Conditions in the Horse; The Continuing Usefulness of the Equine Linkage Map; For monogenic trait mapping; In assembling the genome sequence; References; 3 Physical and comparative maps; Introduction; Horse Chromosomes; Chromosome number; Chromosome identification; Chromosome size; The horse karyotype 327 $aGene Mapping in Horses - Historical BackgroundCytogenetic Map; Fluorescence in situ hybridization; FISH mapping in the horse; Multicolor and high-resolution FISH; Physical mapping using flow-sorted and microdissected chromosomes; FISH for mapping chromosome and genome rearrangements; Somatic Cell Hybrid (SCH) Panels and Synteny Mapping; Radiation Hybrid (RH) Panels and RH Mapping; RH mapping methodology; Horse RH panels; RH mapping in the horse; Comparative Map; Zoo-FISH maps; High-resolution comparative maps; Concluding remarks; References; 4 The Y-Chromosome; Introduction; Cytogenetics 327 $aMolecular ProbesGenes; Maps; The Pseudoautosomal Region (PAR); Disorders; Male infertility; The PAR and sex chromosome aneuploidies; Sex reversal syndrome; Polymorphism and Population Studies; Y chromosome in Other Equids and Perissodactyls; Cytogenetics; Genes and mapping; Polymorphism; Concluding Remarks; Acknowledgments; References; 5 Unexpected structural features of the equine major histocompatibility complex; Organization and Gene Content of the Model MHC; Some MHC Genes Are Highly Polymorphic; The Molecular Map of the Equine Leucocyte Antigen Complex; RT-PCR 327 $aChromatin Modifications Associated with TranscriptionSummary; References; 6 Assembly and analysis of the equine genome sequence; Introduction; Sequencing a Genome; Features of the Equine Genome Assembly; Comparison with Genetic Maps; Repetitive Elements; Synteny with Humans; Special Centromeres; Genes; A Single Nucleotide Polymorphism Map; Genomic Attributes of Equine Breeds; Summary; Acknowledgments; References; 7 Genomic tools and resources: Development and applications of an equine SNP genotyping array; Introduction; Development of an Equine SNP Genotyping Array 327 $aEquine SNP50 Beadchip Design and Validation in the Domestic Horse 330 $aAnalysis of the equine genome began just over a decade ago, culminating in the recent complete sequencing of the horse genome. The availability of the equine whole genome sequence represents the successful completion of an important era of equine genome analysis, and the beginning of a new era where the sequence information will catalyze the development of new tools and resources that will permit study of a range of traits that are economically important and are significant to equine health and welfare. Equine Genomics provides a timely comprehensive overview of equine genomic res 606 $aHorses$xGenetics 606 $aDomestic animals$xGenome mapping 615 0$aHorses$xGenetics. 615 0$aDomestic animals$xGenome mapping. 676 $a636.1/0821 701 $aChowdhary$b Bhanu P$01640401 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910825989503321 996 $aEquine genomics$93983922 997 $aUNINA