LEADER 04025nam 2200721Ia 450 001 9910825859103321 005 20200520144314.0 010 $a0-429-14676-0 010 $a1-282-84872-0 010 $a9786612848728 010 $a1-4200-7344-3 024 7 $a10.3109/9781420073447 035 $a(CKB)2670000000047999 035 $a(EBL)1406187 035 $a(SSID)ssj0000427060 035 $a(PQKBManifestationID)11290110 035 $a(PQKBTitleCode)TC0000427060 035 $a(PQKBWorkID)10390847 035 $a(PQKB)10362202 035 $a(MiAaPQ)EBC1406187 035 $a(MiAaPQ)EBC592632 035 $a(Au-PeEL)EBL1406187 035 $a(CaPaEBR)ebr10422871 035 $a(CaONFJC)MIL284872 035 $a(OCoLC)670412826 035 $a(OCoLC)761845461 035 $a(Au-PeEL)EBL592632 035 $a(OCoLC)658536461 035 $a(FINmELB)ELB140823 035 $a(EXLCZ)992670000000047999 100 $a20100819d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aReproductive toxicology /$fedited by Robert W. Kapp Jr., Rochelle W. Tyl 205 $a3rd ed. 210 $aNew York $cInforma Healthcare$d2010 215 $a1 online resource (422 p.) 225 1 $aTarget organ toxicology series 300 $aDescription based upon print version of record. 311 $a1-4200-7343-5 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Preface; Acknowledgments; Contents; Contributors; Chapter 1 Biology and physiology of fertilization; Chapter 2 Normal development of the male reproductive system; Chapter 3 Normal development of the female reproductive system; Chapter 4 Development of the mammalian nervous system; Chapter 5 FDA and ICH perspectives on reproductive and developmental toxicology; Chapter 6 EPA and OECD perspectives on reproductive and developmental toxicity testing; Chapter 7 Reproductive study evolution and IND submissions for the Food and Drug Administration 327 $aChapter 8 Developmental immunotoxicologyChapter 9 Developmental neurotoxicology; Chapter 10 Developmental toxicology of the respiratory system; Chapter 11 Developmental toxicity of the kidney; Chapter 12 Developmental toxicology of the liver; Chapter 13 Cardiovascular development and malformation; Chapter 14 Male reproductive toxicity; Chapter 15 Female reproductive toxicity; Chapter 16 Toxicity of the pregnant female reproductive system; Chapter 17 Epigenetic reproductive toxicants 327 $aChapter 18 Cumulative effects of in utero administration to mixtures of reproductive toxicants in the male rat: a systems biology frameworkChapter 19 Metals and metal compounds in reproductive and developmental toxicology; Chapter 20 Omics in reproductive and developmental toxicology; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; V; W; X; Y; Z 330 $aThoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology's contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research.This ground-breaking resource includes:New and important critical mechanistic topics such as epigenetics and omicsThe first s 410 0$aTarget organ toxicology series. 606 $aReproductive toxicology 606 $aToxicology 615 0$aReproductive toxicology. 615 0$aToxicology. 676 $a616.6/5 701 $aKapp$b Robert W$01683782 701 $aTyl$b Rochelle W$01683783 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910825859103321 996 $aReproductive toxicology$94054831 997 $aUNINA