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100   $a20010815d2001      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aStanding operating procedures for developing acute exposure guideline levels for hazardous chemicals /$fSubcommittee on Acute Exposure Guideline Levels ...[et al.]
205   $a1st ed.
210   $aWashington ;$a[England] $cNational Academy Press$dc2001
215   $a1 online resource (224 p.)
300   $aDescription based upon print version of record.
311   $a0-309-07553-X 
320   $aIncludes bibliographical references.
327   $a""Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals""; ""Copyright""; ""Preface""; ""Contents""; ""Introduction""; ""REVIEW OF THE NAC DOCUMENT""; ""REFERENCES""; ""Roster  National Advisory Committee for Acute Exposure Guideline Levels (NAC/AEGL Committee) for Hazardous Substances""; ""COMMITTEE MEMBERS""; ""Past Committee Members""; ""Participants from Cooperative Partner Countries""; ""Other Participants""; ""Oak Ridge National Laboratory Staff""; ""AEGL Program Senior Staff""; ""Appendix""; ""Preface""
327   $a""1. Overview of AEGL Program and NAC/AEGL Committee""""HISTORY""; ""PURPOSE AND OBJECTIVES OF THE AEGL PROGRAM AND THE NAC/AEGL COMMITTEE""; ""COMMITTEE MEMBERSHIP AND ORGANIZATIONAL STRUCTURE""; ""SELECTION OF CHEMICALS FOR AEGL DEVELOPMENT""; ""SCIENTIFIC CREDIBILITY OF AEGL VALUES""; ""THE AEGL DEVELOPMENT AND PEER-REVIEW PROCESS""; ""Stage 1: Draft AEGLs""; ""Stage 2: Proposed AEGLs""; ""Stage 3: Interim AEGLs""; ""Stage 4: Final AEGLs""; ""OPERATION OF THE NAC/AEGL COMMITTEE""; ""VALUE OF A COLLABORATIVE EFFORT IN THE AEGL PROGRAM""; ""APPLICATIONS OF THE AEGL VALUES""
327   $a""2. Derivation of AEGL Values""""2.1 CHARACTERIZATION OF AEGLS""; ""2.2 EMPIRICAL TOXICOLOGIC ENDPOINTS AND METHODS FOR DETERMINING EXPOSURE CONCENTRATIONS USED TO DERIVE AEGLS 1, 2, AND 3""; ""2.2.1 Selection of the Highest Exposure Level at Which the Effects That Define an AEGL Are Not Observed""; ""2.2.2 Selection of Health-Effect Endpoints for AEGL-1, AEGL-2, and AEGL-3""; ""2.2.2.1 AEGL-1 Endpoints""; ""2.2.2.1.1 No Value Establisheda???AEGL-1 Is Close to or Exceeds AEGL-2""; ""2.2.2.1.2 No Value Establisheda???Insufficient Data""
327   $a""2.2.2.1.3 Highest Experimental Exposure Without an AEGL-1 Effect""""2.2.2.1.4 Effect Level for a Response""; ""2.2.2.2 AEGL-2 Endpoints""; ""2.2.2.2.1 Highest Experimental Exposure Without an AEGL-2 Effect""; ""2.2.2.2.2 Effect Level for a Toxic Response That Was Not Incapacitating or Not Irreversible""; ""2.2.2.2.3 A Fraction of the AEGL-3 Value""; ""2.2.2.3 AEGL-3 Endpoints""; ""2.2.2.3.1 Highest Exposure Level That Does Not Cause Lethalitya???Experimentally Observed Threshold (AEGL-3 NOAEL)""
327   $a""2.2.2.3.2 Highest Exposure Level That Does Not Cause Lethalitya???Estimated Lethality Thresholda???One-Third of the LC50""""2.2.2.3.3 Highest Exposure Level That Does Not Cause Lethalitya???Benchmark Exposure Calculation of the 5% and 1% Response""; ""2.2.2.3.4 Effect Level for a Response""; ""2.3 GUIDELINES AND CRITERIA FOR THE SEARCH STRATEGY, EVALUATION, SELECTION, AND DOCUMENTATION OF KEY DATA AND SUPPORTINGa???""; ""2.3.1 Search Strategy""; ""2.3.2 Evaluation, Selection, and Documentation of Key and Supporting Data""; ""2.3.3 Elements for Discussion on Data Adequacy and Research Needs""
327   $a""2.4 DOSIMETRY CORRECTIONS FROM ANIMAL TO HUMAN EXPOSURES""
606   $aHazardous substances$xRisk assessment$zUnited States
606   $aChemicals$xPhysiological effect
615  0$aHazardous substances$xRisk assessment
615  0$aChemicals$xPhysiological effect.
676   $a363.1763
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906   $aBOOK
912   $a9910825510803321
996   $aStanding operating procedures for developing acute exposure guideline levels for hazardous chemicals$94123831
997   $aUNINA