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035   $a(DE-B1597)9781400851461
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100   $a20140404h20142014  uy             0
101 0 $aeng
135   $aurnn#---|u||u
181   $ctxt
182   $cc
183   $acr
200 10$aHomology, genes, and evolutionary innovation /$fGu?nter P. Wagner
205   $aCourse Book
210  1$aPrinceton, New Jersey :$cPrinceton University Press,$d2014.
210  4$dİ2014
215   $a1 online resource (495 p.)
300   $aDescription based upon print version of record.
311 0 $a0-691-18067-9 
311 0 $a0-691-15646-8 
320   $aIncludes bibliographical references and index.
327   $tFront matter --$tContents --$tPreface --$tIntroduction: What This Book Aims to Do and What It Is Not --$tPart I. Concepts and Mechanisms --$tPart II. Paradigms and Research Programs --$tReferences --$tIndex
330   $aHomology-a similar trait shared by different species and derived from common ancestry, such as a seal's fin and a bird's wing-is one of the most fundamental yet challenging concepts in evolutionary biology. This groundbreaking book provides the first mechanistically based theory of what homology is and how it arises in evolution. Günter Wagner, one of the preeminent researchers in the field, argues that homology, or character identity, can be explained through the historical continuity of character identity networks-that is, the gene regulatory networks that enable differential gene expression. He shows how character identity is independent of the form and function of the character itself because the same network can activate different effector genes and thus control the development of different shapes, sizes, and qualities of the character. Demonstrating how this theoretical model can provide a foundation for understanding the evolutionary origin of novel characters, Wagner applies it to the origin and evolution of specific systems, such as cell types; skin, hair, and feathers; limbs and digits; and flowers. The first major synthesis of homology to be published in decades, Homology, Genes, and Evolutionary Innovation reveals how a mechanistically based theory can serve as a unifying concept for any branch of science concerned with the structure and development of organisms, and how it can help explain major transitions in evolution and broad patterns of biological diversity.
606   $aDevelopmental genetics
606   $aEvolution (Biology)
606   $aGenetic regulation
610   $aadaptation.
610   $aamniotes.
610   $aangiosperms.
610   $aautopodium.
610   $abiological diversity.
610   $abody parts.
610   $abody plans.
610   $abreasts.
610   $acanalization.
610   $acell fate.
610   $acell type identity.
610   $acell types.
610   $acell typogenesis.
610   $acells.
610   $acharacter identity network.
610   $acharacter identity.
610   $acharacter origination.
610   $acharacter states.
610   $acharacters.
610   $acis-regulatory elements.
610   $aclass.
610   $acommon ancestor.
610   $acommon ancestry.
610   $acryptic genetic variation.
610   $adevelopment.
610   $adevelopmental biology.
610   $adevelopmental evolution.
610   $adevelopmental genetics.
610   $adevelopmental mechanisms.
610   $adevelopmental pathways.
610   $adevelopmental types.
610   $adevelopmental variation.
610   $adevo-evo research.
610   $adigit identity.
610   $adigit loss.
610   $adigits.
610   $aembryonic stem cells.
610   $aevolution.
610   $aevolutionary biology.
610   $aevolutionary developmental biology.
610   $aevolutionary novelties.
610   $afeathers.
610   $afins.
610   $afin?imb transition.
610   $aflower development.
610   $aflower organ identity.
610   $aflower organs.
610   $aflowers.
610   $afunctional specialization.
610   $afunctionalism.
610   $agene duplication.
610   $agene expression.
610   $agene regulatory networks.
610   $agenes.
610   $agenetics.
610   $ahair.
610   $ahierarchical homology.
610   $ahomeotic genes.
610   $ahomologous genes.
610   $ahomologs.
610   $ahomology.
610   $aindividuals.
610   $ainnovation.
610   $alimbs.
610   $ametaphysics.
610   $amodularity.
610   $amolecular genetics.
610   $amolecular structuralism.
610   $amorphological characters.
610   $amorphological variation.
610   $anatural kinds.
610   $anatural selection.
610   $anovel characters.
610   $apaired fins.
610   $apentadactyl limb.
610   $aperianth.
610   $aphenotypic diversity.
610   $aphenotypic evolution.
610   $aphilosophy.
610   $apopulation biology.
610   $apositional information.
610   $arobustness.
610   $ascales.
610   $ascience.
610   $aserial homology.
610   $asignaling centers.
610   $askin appendages.
610   $askin derivatives.
610   $askin.
610   $astructuralism.
610   $atetrapod hand.
610   $atetrapod limbs.
610   $atranscription factor proteins.
610   $atranscription factors.
610   $atranscriptional regulation.
610   $atransposable elements.
610   $atypology.
610   $avariational structuralism.
610   $avertebrates.
615  0$aDevelopmental genetics.
615  0$aEvolution (Biology)
615  0$aGenetic regulation.
676   $a571.8/5
700   $aWagner$b Gu?nter P.$0352381
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910825070703321
996   $aHomology, genes, and evolutionary innovation$94037607
997   $aUNINA