LEADER 05244nam 2200649Ia 450 001 9910824864003321 005 20240313051049.0 010 $a3-527-63937-3 010 $a1-283-64417-7 010 $a3-527-63938-1 010 $a3-527-63936-5 035 $a(CKB)3190000000022653 035 $a(EBL)1037162 035 $a(OCoLC)773301448 035 $a(SSID)ssj0000667291 035 $a(PQKBManifestationID)11955929 035 $a(PQKBTitleCode)TC0000667291 035 $a(PQKBWorkID)10684127 035 $a(PQKB)10879848 035 $a(MiAaPQ)EBC1037162 035 $a(Au-PeEL)EBL1037162 035 $a(CaPaEBR)ebr10608635 035 $a(CaONFJC)MIL395667 035 $a(EXLCZ)993190000000022653 100 $a20110628d2011 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiohybrid systems $enerves, interfaces, and machines /$fedited by Ranu Jung 205 $a1st ed. 210 $aWeinheim $cWiley-VCH$dc2011 215 $a1 online resource (231 p.) 300 $aDescription based upon print version of record. 311 $a3-527-40949-1 320 $aIncludes bibliographical references and index. 327 $aBiohybrid Systems: Nerves, Interfaces, and Machines; Contents; Preface; List of Contributors; 1 Merging Technology with Biology; 1.1 Introduction; 1.2 NeuroDesign; 1.3 The NeuroDesign Approach; 1.4 Neuromorphic Control of a Powered Orthosis for Crutch-Free Walking; 1.5 Frontiers of Biohybrid Systems; 1.6 Chapter Organization; References; 2 Principles of Computational Neuroscience; 2.1 Introduction; 2.2 Some Physiology of Neurons; 2.2.1 Membrane Potential; 2.2.2 Membrane Equivalent Circuit; 2.2.3 Action Potential: Generation and Propagation; 2.3 General Formalisms in Neuronal Modeling 327 $a2.3.1 Conductance-Based Hodgkin-Huxley Model for Action Potential Generation 2.3.2 Chemical and Electrical Synaptic Inputs; 2.3.3 Cable Theory of Neuronal Conduction and Compartmental Modeling; 2.3.4 Calcium and Calcium-Dependent Potassium Currents; 2.3.5 Simplified Neuronal Models; 2.4 Synaptic Coupling and Plasticity; 2.4.1 Modeling Synaptic Plasticity; 2.5 Computational Models of Neuronal Systems for Biohybrid Applications; 2.6 Resources; References; 3 Neuromorphic Electronic Design; 3.1 Choices for Neuromorphic Circuits: Digital versus Analogue; 3.2 The Breadth of Neuromorphic Systems 327 $a3.3 The Fundamental Processing Unit: The Neuron 3.3.1 Conductance-Based Modeling; 3.3.2 Compartmental Modeling; 3.3.2.1 The Dendritic Compartment: Home to the Synapses; 3.3.2.2 The Somatic Compartment: Spike-Based Processing and the Integrate-and-Fire Model; 3.3.2.3 The Axonal Compartment: Address-Event Representation; 3.4 Sensing the Environment; 3.4.1 Vision; 3.4.2 The Silicon Retina; 3.4.3 Audition; 3.4.3.1 Silicon Cochlea Modeling; 3.5 Conclusions; 3.6 Resources; References; 4 Principles of Neural Signal Processing; 4.1 Introduction; 4.2 Point Process Theory 327 $a4.2.1 Definition of a Point Process 4.2.2 Examples of Point Processes; 4.2.2.1 The Poisson Process; 4.2.2.2 Renewal Processes; 4.2.2.3 Markov Point Processes; 4.2.2.4 Non-Markovian Point Processes; 4.2.3 Multiple Point Processes; 4.3 Analyzing a Point Process; 4.3.1 The Interval Histogram and Hazard Function; 4.3.2 The PST Histogram; 4.3.3 Characterizing Multiple Point Processes; 4.4 Dynamic Neural Processing; 4.5 Information Theory and Neural Signal Processing; 4.5.1 Data Processing Theorem; 4.5.2 Channel Capacity; 4.5.3 Rate Distortion Theory; 4.5.4 Application to Biohybrid Systems 327 $a4.6 Summary References; 5 Dynamic Clamp in Biomimetic and Biohybrid Living-Hardware Systems; 5.1 What is a Dynamic Clamp?; 5.1.1 The Digital Dynamic Clamp; 5.2 Dynamic Clamp Performance and Limitations; 5.3 Experimental Applications of Dynamic Clamp; 5.3.1 Example Application 1: Neuronal Gain Control; 5.3.1.1 Synaptic Background Noise Mechanism; 5.3.1.2 Synaptic Depression Mechanism; 5.3.2 Example Application 2: Constructing Artificial Neuronal Circuits; 5.4 Dynamic Clamp System Implementations and Future; 5.4.1 Fundamental Considerations; 5.4.2 Recent and Future Implementations; 5.5 Resources 327 $aReferences 330 $aThe discipline of neurodesign is a highly interdisciplinary one, while at the same time in the process of maturing towards real-life applications. The breakthrough about to be achieved is to close the loop in communication between neural systems and electronic and mechatronic systems and actually let the nervous system adapt to the feedback from the man-made systems. To master this loop, scientists need a sound understanding of neurology, from the cellular to the systems scale, of man-made systems and how to connect the two. These scientists comprise medical scientists, neurologists and physio 606 $aNeurobiology 606 $aMedical physics 615 0$aNeurobiology. 615 0$aMedical physics. 676 $a612.81 701 $aJung$b Ranu$01693913 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910824864003321 996 $aBiohybrid systems$94072077 997 $aUNINA