LEADER 05229nam 2200721 450 001 9910824416603321 005 20200520144314.0 010 $a1-118-76035-2 010 $a1-118-76033-6 035 $a(CKB)3710000000551690 035 $a(EBL)4305696 035 $a(SSID)ssj0001593659 035 $a(PQKBManifestationID)16289326 035 $a(PQKBTitleCode)TC0001593659 035 $a(PQKBWorkID)14831472 035 $a(PQKB)11538003 035 $a(PQKBManifestationID)16202136 035 $a(PQKBWorkID)14831471 035 $a(PQKB)23075961 035 $a(MiAaPQ)EBC4305696 035 $a(DLC) 2015044701 035 $a(Au-PeEL)EBL4305696 035 $a(CaPaEBR)ebr11137209 035 $a(OCoLC)935254348 035 $a(PPN)194702960 035 $a(EXLCZ)993710000000551690 100 $a20160115h20162016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular neuroendocrinology $efrom genome to physiology /$feditors, David Murphy & Harold Gainer ; cover design by Dan Jubb 210 1$aChichester, England :$cWiley Blackwell,$d2016. 210 4$dİ2016 215 $a1 online resource (693 p.) 225 1 $aMasterclass in Neuroendocrinology Series 300 $aDescription based upon print version of record. 311 $a1-118-76036-0 311 $a1-118-76037-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aTitle Page; Table of Contents; List of Contributors; Series Preface; About the Companion Website; Introduction; Part A: Genome and Genome Expression; CHAPTER 1: Evolutionary Aspects of Physiological Function and Molecular Diversity of the Oxytocin/Vasopressin Signaling System; 1.1 Evolution of peptidergic signaling; 1.2 The discovery of neuropeptide signaling components in the era of genomics; 1.3 Evolutionary aspects of OXT/AVP diversity; 1.4 Physiology of OXT and AVP signaling: from worm to man; 1.5 Perspectives; Acknowledgments; References; CHAPTER 2: The Neuroendocrine Genome: 327 $a2.1 The discovery of neuropeptides 2.2 Characteristics of neuropeptides; 2.3 Neuropeptide genes in the genome; 2.4 Perspectives; Acknowledgments; References; Further reading; CHAPTER 3: Transcriptome Dynamics; 3.1 Approaching transcriptome dynamics; 3.2 Transcriptome dynamics in neuroendocrine systems; 3.3 Transcriptome dynamics in the pineal gland: lessons from different approaches; 3.4 SN-NICHD transcriptome profiling web page; 3.5 Perspectives; References; CHAPTER 4: New Players in the Neuroendocrine System:; 4.1 Non-coding RNA contribution to gene regulation 327 $a4.2 Central role of the hypothalamus as a neuroendocrine organ 4.3 The pituitary gland and its central control of the peripheral endocrine system; 4.4 The pineal gland - a connector between external environment and internal homeostasis; 4.5 Perspectives; References; CHAPTER 5: Transcription Factors Regulating Neuroendocrine Development, Function, and Oncogenesis; 5.1 The key players in transcriptional regulation; 5.2 Classes of neuroendocrine-associated TFs; 5.3 REST: a zinc finger TF with complex regulation and diverse function; 5.4 Cooperation of TFs in neuroendocrine phenotype and function 327 $a5.5 Perspectives References; CHAPTER 6: Epigenetics; 6.1 Introduction; 6.2 Early life adversity shapes the HPA axis; 6.3 Epigenetic mechanisms: changes in the regulation of gene activity and expression that are not dependent on gene sequence; 6.4 Methods of epigenetic analysis; 6.5 Alterations in epigenetic processes; 6.6 The epigenome and early life adversity; 6.7 Perspectives; References; Further reading; Part B: Proteins, Post translational Mechanisms, and Receptors; CHAPTER 7: Proteome and Peptidome Dynamics; 7.1 Introduction; 7.2 Classic neuropeptides and proteins in the RSP 327 $a7.3 Techniques used to study the rate of peptide biosynthesis 7.4 Dynamics of intracellular proteins and peptides; 7.5 Perspectives; References; CHAPTER 8: Neuropeptidomics; 8.1 Neuropeptides - one gene, multiple products; 8.2 Mining the neuropeptidome 21st-century style using mass spectrometry-based 'omics approaches; 8.3 What do all these peptides do? Follow-up functional studies; 8.4 Perspectives; Acknowledgments; References; Further reading; CHAPTER 9: Posttranslational Processing of Secretory Proteins; 9.1 Posttranslational modifications of secretory proteins 327 $a9.2 The family of proprotein convertases 330 $a"Discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification"--$cProvided by publisher. 410 0$aMasterclass in neuroendocrinology series. 606 $aNeuroendocrinology$xMolecular apects 615 0$aNeuroendocrinology$xMolecular apects. 676 $a612.8 686 $aSCI089000$2bisacsh 702 $aMurphy$b David$f1957- 702 $aGainer$b Harold 702 $aJubb$b Dan 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910824416603321 996 $aMolecular neuroendocrinology$93954343 997 $aUNINA