LEADER 05642nam 2200661 450 001 9910824331303321 005 20230803194943.0 010 $a1-908230-93-2 035 $a(CKB)2670000000427613 035 $a(EBL)1909039 035 $a(SSID)ssj0001164150 035 $a(PQKBManifestationID)11962766 035 $a(PQKBTitleCode)TC0001164150 035 $a(PQKBWorkID)11181111 035 $a(PQKB)10088928 035 $a(MiAaPQ)EBC1909039 035 $a(MiAaPQ)EBC5897831 035 $a(Au-PeEL)EBL5897831 035 $a(OCoLC)861536346 035 $a(EXLCZ)992670000000427613 100 $a20191011d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMollicutes $emolecular biology and pathogenesis /$fedited by Glenn F. Browning, Asia-Pacific Centre for Animal Health, Faculty of Veterninary Science, the University of Melbourne, Victoria, Australia and Christine Citti, INRA, E?cole Nationale Ve?te?rinaire de Toulouse and UMR 1225 Interactions Ho?tes-Agents Pathoge?nes, Toulouse, France 210 1$aNorfolk, England :$cCaister Academic Press,$d[2014] 210 4$dİ2014 215 $a1 online resource (346 p.) 300 $aDescription based upon print version of record. 311 $a1-908230-30-4 320 $aIncludes bibliographical references and index. 327 $aContents; Contributors; Current books of interest; Preface; 1: The Contentious Taxonomy of Mollicutes; Paths to the present; Current controversies; Genome sequence-based taxonomy: a path to the future?; 2: Genomic Mosaics; The Mollicutes in the era of genomics; General features of Mycoplasma genomes; The impact of horizontal gene transfer on Mycoplasma genomics; Conclusions; 3: Molecular Genetic Tools for Mollicutes; Introduction; Transformation of Mollicutes; Random mutagenesis through transposition; Targeted mutagenesis through homologous recombination; Production of unmarked mutations 327 $aVectors for gene expression/disruption in MollicutesGene expression in Mollicutes; Discussion; 4: Identification and Characterization of Virulence Genes in Mycoplasmas; Introduction; Adhesins; Invasion; Toxin production; Mimicry; Immune evasion; Immunostimulation; Immunosuppression; Multifunctional proteins; Protein secretion; Scavenging complex nutrients; Other virulence factors; Regulation of virulence genes; Challenges for the future; 5: Post-translational Modification of Proteins in the Mollicutes; Introduction; Post-translational protein processing plays a key role in protein secretion 327 $aSignal sequences are critical for trafficking proteins to secretion pathwaysAre signal sequences removed from secreted mycoplasma proteins?; Signal sequences are removed from secreted proteins in Mycoplasma pneumoniae; Evidence that proteins are subject to endoproteolytic cleavage in Mycoplasma pneumoniae; Signal sequences are not removed during secretion of large mass adhesins in Mycoplasma hyopneumoniae; Why are adhesins targets of endoproteolytic cleavage?; Processing of lipoproteins; Endoproteolytic processing in Mycoplasma gallisepticum; Protein phosphorylation and acetylation 327 $a6: Multifunctional Cytoadherence FactorsIntroduction; Cytoadherence factors; Non-proteinaceous cytoadherence factors with multiple functions; Membrane proteins as cytoadhesins; Cytoadhesins that are variable in phase, size and antigenicity; Cytoadhesins that help to move; Immune evasion; MSCRAMMs; Mimicry; Secreted cytoadhesins; Moonlighting cytoadhesins; Vice versa: cytoplasmic factors with cytoadhesive functions; 7: The Glycocalyx of Mollicutes; Introduction; Capsule; Polysaccharides; Glycoproteins; Glycolipids; Glycoconjugate synthesis machinery; Summary 327 $a8: Glycosidase Activity in MollicutesIntroduction; Virulence-associated glycosidases in Mycoplasmas; Putative roles in cellular biology or disease processes of mycoplasmas; Acquisition, diversity and evolutionary fitness; Therapeutic potential; 9: Current Insights into Phase and Antigenic Variation in Mycoplasmas; Introduction; Genetic mechanisms of Mycoplasma phase and antigenic variation at glance; Genetic events mediating phase and antigenic variation in selected Mycoplasma species; Biological role and significance of mycoplasma surface antigenic variation; Outlook and future perspectives 327 $a10: Spiroplasma Transmission from Insects to Plants 330 $aMollicutes are a class of simple bacteria characterized by the lack of a bacterial cell wall and their very small genomes (580 kb to 2200 kb). This phylogenetically coherent group contains a broad range of different plant and animal pathogens, making it an ideal model for understanding gene function, gene regulation, and the evolution of virulence factors in other bacterial pathogens. The recent development of improved tools for manipulating mollicute genomes has transformed research in this area, permitting new insights into mollicute molecular and cellular biology. An interesting fact to eme 606 $aMycoplasmatales 606 $aBacterial genetics 606 $aVirulence (Microbiology) 606 $aMycoplasma diseases 615 0$aMycoplasmatales. 615 0$aBacterial genetics. 615 0$aVirulence (Microbiology) 615 0$aMycoplasma diseases. 676 $a579.3135 702 $aBrowning$b Glenn 702 $aCitti$b Christine 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910824331303321 996 $aMollicutes$94083138 997 $aUNINA