LEADER 05510nam 2200685Ia 450 001 9910824325903321 005 20240514070114.0 010 $a1-283-40110-X 010 $a9786613401106 010 $a1-118-15867-9 010 $a1-118-15866-0 010 $a1-118-15864-4 035 $a(CKB)2670000000133805 035 $a(EBL)818495 035 $a(OCoLC)773301080 035 $a(SSID)ssj0000575943 035 $a(PQKBManifestationID)11376595 035 $a(PQKBTitleCode)TC0000575943 035 $a(PQKBWorkID)10553672 035 $a(PQKB)10501024 035 $a(MiAaPQ)EBC818495 035 $a(Au-PeEL)EBL818495 035 $a(CaPaEBR)ebr10577666 035 $a(CaONFJC)MIL340110 035 $a(PPN)171571398 035 $a(EXLCZ)992670000000133805 100 $a20110714d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHigh-density lipoproteins $estructure, metabolism, function, and therapeutics /$f[edited by] Anatol Kontush, M. John Chapman 205 $a1st ed. 210 $aHoboken, N.J. $cJohn Wiley & Sons, Inc.$dc2012 215 $a1 online resource (650 p.) 300 $aDescription based upon print version of record. 311 $a0-470-40821-9 320 $aIncludes bibliographical references and index. 327 $aHIGH-DENSITY LIPOPROTEINS; CONTENTS; PREFACE; ACKNOWLEDGMENTS; ABBREVIATIONS; SECTION 1 NORMAL FUNCTIONAL HIGH-DENSITY LIPOPROTEIN; 1 COMPOSITION; 1.1 Proteome; Apolipoproteins; Apolipoprotein A-I; ApoA-II; ApoA-IV; ApoA-V; ApoC-I, ApoC-II, ApoC-III, ApoC-IV; ApoD; ApoE; ApoF; ApoH; ApoJ; ApoL-I; ApoM; Other Apolipoproteins; Enzymes; LCAT; PON1 and PON3; PAF-AH (LpPLA2); GSPx-3; Lipid Transfer Proteins; PLTP; CETP; Acute-Phase Response Proteins; Serum Amyloid A; Other Proteins; Complement Components; Proteinase Inhibitors and Related Proteins; Other Protein Components; 1.2 Lipidome 327 $aPhospholipidsSteroids; Cholesteryl Esters; Triglycerides; Minor Lipids; 2 HETEROGENEITY; 2.1 Heterogeneity in Physicochemical Properties; Heterogeneity in Density; Heterogeneity in Electrophoretic Mobility; Heterogeneity in Size; 2.2 Heterogeneity in Chemical Composition; Heterogeneity in Proteins; Heterogeneity in Lipids; 2.3 Relationships Between HDL Subfractions Separated by Different Methods; 3 STRUCTURE; 3.1 Lipid-Free ApoA-I; 3.2 Discoid HDL; 3.3 Spherical HDL; 4 METABOLISM; 4.1 Formation and Intravascular Remodeling; ABC Transporters; ABCA1; ABCG1; Enzymes; LCAT; Lipases 327 $aLipid Transfer ProteinsCETP; PLTP; Receptors; SR-BI; 4.2 Catabolism; 5 EPIDEMIOLOGY; 5.1 Epidemiology of HDL-C; HDL-C and Cardiovascular Risk; Relevance Across Multiple Populations and Disease States; HDL-C and Other Cardiovascular Risk Factors; Prevalence of Low HDL-C; HDL-C and Cardiovascular Risk in Patients Receiving Statins; HDL-C and Other Major Diseases; 5.2 Epidemiology of HDL-Associated Proteins and Enzymes; ApoA-I; Other Apolipoproteins; SAA; PON1; PAF-AH; Other Enzymes; Lipid Transfer Proteins; 5.3 Epidemiology of HDL Particle Subpopulations; Separated by Density 327 $aSeparated by Electrophoretic MobilitySeparated by Composition; Separated by Size; 6 GENETICS; 6.1 ABC Transporters and Other Receptors; ABCA1; SR-BI; LDL Receptor; 6.2 Apolipoproteins; ApoA-I; ApoA-V; ApoC-III; ApoE; 6.3 Enzymes; LCAT; PON1; LPL; Hepatic Lipase; Endothelial Lipase; 6.4 Lipid Transfer Proteins; CETP; 6.5 Other Genes; 6.6 Gene Interactions; 7 BIOLOGIC ACTIVITIES; 7.1 Cholesterol Efflux Capacity; Mechanisms of Cellular Cholesterol Efflux; ABCA1-Mediated Efflux; ABCG1-Mediated Efflux; SR-BI-Mediated Efflux; Other Pathways; Role of HDL Components; Proteins; Lipids 327 $aFunctional Heterogeneity of HDL7.2 Antioxidative Activity; Mechanisms of Protection Against Oxidative Stress; Role of HDL Components; Apolipoproteins; Enzymes; Lipids; Functional Heterogeneity of HDL; 7.3 Anti-Inflammatory Activity; Mechanisms of Anti-Inflammatory Protection; Role of HDL Components; Proteome; Lipidome; Functional Heterogeneity of HDL; 7.4 Cytoprotective Activity; Mechanisms of Cytoprotection; Role of HDL Components; Proteome; Lipidome; Functional Heterogeneity of HDL; 7.5 Anti-Infectious Activity; Mechanisms of Protection from Infection; Role of HDL Components; Proteome 327 $aLipids 330 $a A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipo 606 $aHigh density lipoproteins$xMetabolism 606 $aCardiovascular system$xDiseases$xTreatment 615 0$aHigh density lipoproteins$xMetabolism. 615 0$aCardiovascular system$xDiseases$xTreatment. 676 $a572.68 701 $aKontush$b Anatol$01650286 701 $aChapman$b M. John$f1945-$01650287 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910824325903321 996 $aHigh-density lipoproteins$93999584 997 $aUNINA