LEADER 03429nam 2200601 450 001 9910824191403321 005 20230807210750.0 010 $a1-118-77238-5 010 $a1-118-77228-8 035 $a(CKB)2670000000617977 035 $a(EBL)1895594 035 $a(SSID)ssj0001515454 035 $a(PQKBManifestationID)11887232 035 $a(PQKBTitleCode)TC0001515454 035 $a(PQKBWorkID)11482864 035 $a(PQKB)10940120 035 $a(MiAaPQ)EBC1895594 035 $a(DLC) 2015001033 035 $a(Au-PeEL)EBL1895594 035 $a(CaPaEBR)ebr11056823 035 $a(CaONFJC)MIL788240 035 $a(OCoLC)900159220 035 $a(EXLCZ)992670000000617977 100 $a20150601h20152015 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMatrix metalloproteinase biology /$fedited by Irit Sagi, Jean P. Gaffney 210 1$aHoboken, New Jersey :$cWiley-Blackwell,$d2015. 210 4$dİ2015 215 $a1 online resource (253 p.) 300 $aDescription based upon print version of record. 311 $a1-118-77229-6 311 $a1-118-77232-6 320 $aIncludes bibliographical references and index. 327 $aMatrix metalloproteinases : from structure to function / Maciej J. Stawikowski and Gregg B. Fields -- Dynamics and mechanisms of substrate recognition by matrix metalloproteinases / Ivan E. Collier and Gregory Goldberg -- Matrix metalloproteinases : structure and dynamics in substrates recognition and processing / Marco Fragai, Claudio Luchinat -- Metzincin modulators : beyond the active site / Dmitriy Minond -- Therapeutics targeting matrix metalloproteinases / Jillian Cathcard, Ashleigh Pulkoski-Gross, Stanley Zucker, and Jian Cao -- Matrix metalloproteinases : modification of extracellular matrix-medicated signaling / Howard C. Crawford and M. Sharon Stack -- Meprin and Adam metalloproteinases : two sides of the same coin? / Christopher Becker-Pauly and Stefan Rose-John -- Metalloproteinases in innate immunity and disease / Antoine Dufour and Christopher Overall -- MMPS : from genomics to degradomics / Barbara Gru?nwald, Pascal Schlage, Achim Kru?ger, and Ulrich auf dem Keller -- Biology and clinical significance of MMPS / Di Jia, Roopali Roy, and Marsha A. Moses. 330 $aDiscussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, Matrix Metalloproteinase Biologyis a collection of chapters written by leaders in the field of MMPs. The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases. The text first 606 $aMetalloproteinases$vLaboratory manuals 606 $aMetalloproteins$xResearch$xMethodology 615 0$aMetalloproteinases 615 0$aMetalloproteins$xResearch$xMethodology. 676 $a572.76 702 $aSagi$b Irit 702 $aGaffney$b Jean P. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910824191403321 996 $aMatrix metalloproteinase biology$94010977 997 $aUNINA