LEADER 04424nam 2200673Ia 450 001 9910824139503321 005 20240418145541.0 010 $a0-19-756250-7 010 $a0-19-988665-2 010 $a1-281-99848-6 010 $a9786611998486 010 $a0-19-804351-1 035 $a(CKB)1000000000718579 035 $a(EBL)416008 035 $a(OCoLC)476246440 035 $a(SSID)ssj0000262394 035 $a(PQKBManifestationID)11220992 035 $a(PQKBTitleCode)TC0000262394 035 $a(PQKBWorkID)10269465 035 $a(PQKB)11351084 035 $a(MiAaPQ)EBC416008 035 $a(StDuBDS)EDZ0002341663 035 $a(Au-PeEL)EBL416008 035 $a(CaPaEBR)ebr10288354 035 $a(CaONFJC)MIL199848 035 $a(EXLCZ)991000000000718579 100 $a20080909d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTriumph of the heart $ethe story of statins /$fJie Jack Li 205 $a1st ed. 210 $aNew York $cOxford University Press$d2009 215 $a1 online resource (220 p.) 225 1 $aOxford scholarship online 300 $aPreviously issued in print: 2009. 311 $a0-19-532357-2 320 $aIncludes bibliographical references (p. 175-188) and index. 327 $aForeword; Contents; 1 Cholesterol; The Janus-Faced Molecule; One of the 10 Greatest Discoveries in Medicine; The Good, the Bad, and the Ugly; Hitler's Gift; The Framingham Heart Study; The Receptor; 2 Genesis of Statins; Early Cholesterol Drugs; Nicotinic acid; Resins; Fibrates; I Refuse to Sign Th is Report!; Birth of Statins; Endo's discovery of the first statin; The fate of mevastatin; Endo's fate; How do statins work?; 3 Merck's Triumph; Merck; Humble beginnings; George W. Merck; Penicillin; Cortisone; Streptomycin; Glorious history; Mevacor and Zocor; The poor Greek immigrant kid 327 $aPreludeDiscovery; Halt!; Triumph; The Company, the Drugs, and the Inventors Today; 4 Discovery of Lipitor; Splendid History; Parke, Davis & Company; Dilantin; Chloromycetin; The pill; Lopid; Roger S. Newton; Bruce D. Roth; The Discovery of Lipitor; Shoulders of giants; The first success . . . and disappointment; The second refrain; CI-971; CI-981; 5 Development of Lipitor; Checkered Life; Chiral or Not, You Have to Make It First; Clinical Trials-Divine Providence?; Canter and the FDA; What's in a Name?; A Marketing Partner; 6 To Market, to Market; Pfizer Inc. 327 $aThe small drug firm in Brooklyn made bigPenicillin; Drugs of its own; Windfall: The Era of Blockbusters; Viagra; Zoloft; Diflucan; Zithromax; Norvasc; The Merger; PROVE-IT; The Patent Litigation; 7 Baycol, Crestor, and Cholesterol Drugs beyond Statins; The Story of Baycol; Crestor; Cholesterol Drugs beyond Statins; Zetia and Vytorin; Torcetrapib, a bitter disappointment; ApoA-1 Milano and Newton; 8 Reflections; Triumph of the Heart; Statins set a high standard in efficacy; Statins set a high standard in safety; Statins set a high standard in financial benefits 327 $aThe Drug Industry and the Blockbuster ModelAppendix: Drug Names; Notes and References; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z 330 8 $aOver 25 million people in the U.S. alone have benefited from statins (such drugs as Lipitor, Zocor, Crestor, Pravachol) in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells the fascinating story of statins. Drawn from interviews with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterise major discoveries. 410 0$aOxford scholarship online. 606 $aStatins (Cardiovascular agents)$xHistory 606 $aAnticholesteremic agents 615 0$aStatins (Cardiovascular agents)$xHistory. 615 0$aAnticholesteremic agents. 676 $a615/.718 700 $aLi$b Jie Jack$0440094 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910824139503321 996 $aTriumph of the heart$94064783 997 $aUNINA