LEADER 03809nam 22006254a 450 001 9910823933503321 005 20200520144314.0 010 $a1-281-21466-3 010 $a9786611214661 010 $a0-470-75503-2 010 $a0-470-75584-9 010 $a1-4051-2853-4 035 $a(CKB)1000000000342051 035 $a(EBL)214239 035 $a(OCoLC)437065787 035 $a(SSID)ssj0000131243 035 $a(PQKBManifestationID)11137214 035 $a(PQKBTitleCode)TC0000131243 035 $a(PQKBWorkID)10026056 035 $a(PQKB)10575436 035 $a(MiAaPQ)EBC214239 035 $a(Au-PeEL)EBL214239 035 $a(CaPaEBR)ebr10233038 035 $a(CaONFJC)MIL121466 035 $a(EXLCZ)991000000000342051 100 $a20030513d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCough $ecauses, mechanisms, and therapy /$fedited by Kian Fan Chung, John G. Widdicombe, Homer A. Boushey 205 $a1st ed. 210 $aMalden, Mass. $cBlackwell Pub.$d2003 215 $a1 online resource (318 p.) 300 $aDescription based upon print version of record. 311 $a1-4051-1634-X 320 $aIncludes bibliographical references and index. 327 $aCough: Causes, Mechanisms and Therapy; Contents; Contributors; Preface; Section 1: Introduction; 1 The clinical and pathophysiological challenge of cough; 2 Epidemiology of cough; 3 A brief overview of the mechanisms of cough; Section 2: Cough in the Clinic; 4 Clinical assessment of cough; 5 Measurement and assessment of cough; 6 Cough sensitivity: the use of provocation tests; 7 Causes, assessment and measurement of cough in children; 8 The quality of life in coughers; Section 3: Clinical Conditions with Cough; 9 Cough in lower airway infections; 10 Cough and gastro-oesophageal reflux 327 $a11 Cough in postnasal drip, rhinitis and rhinosinusitis12 Cough and airway hyperresponsiveness; 13 Cough in chronic obstructive pulmonary disease; 14 Cough in suppurative airway diseases; 15 Cough in cancer patients; Section 4: Pathophysiology; 16 Sensory pathways for the cough reflex; 17 Neurogenesis of cough; 18 Plasticity of vagal afferent fibres mediating cough; 19 Motor mechanisms and the mechanics of cough; 20 Mucus hypersecretion and mucus clearance in cough; 21 Animal models of cough; Section 5: Therapy 327 $a22 Mechanisms of actions of centrally acting antitussives-electrophysiological and neurochemical analysis23 Pharmacology of peripherally acting antitussives; 24 Current and potential future antitussive therapies; 25 Placebo effects of antitussive treatments on cough associated with acute upper respiratory tract infection; 26 Mucoactive agents for the treatment of cough; 27 Management of cough; Index 330 $aCough is the most familiar symptom of respiratory disease, and a problem which general practitioners must deal with on a daily basis. This timely volume draws together a wealth of recent research into the mechanisms, pharmacology and therapies for cough, and places these in clinical context. The text incorporates guidelines on the most common causes of cough, discusses treatments and pitfalls in management, summarizes current research on physiology, pharmacology and treatment of cough, and gives practical advice on diagnosis and management issues for the clinician. Cough: Causes, Mech 606 $aCough 615 0$aCough. 676 $a616.2 701 $aChung$b K. Fan$f1951-$0879011 701 $aWiddicombe$b John G$0985507 701 $aBoushey$b Homer A$0100621 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910823933503321 996 $aCough$92252656 997 $aUNINA