LEADER 01290nam--2200397---450- 001 990002258740203316 005 20140702131630.0 035 $a000225874 035 $aUSA01000225874 035 $a(ALEPH)000225874USA01 035 $a000225874 100 $a20041210d1963----km-y0itay0103----ba 101 0 $afre$aita 102 $aIT 105 $a||||||||001yy 200 1 $aDictionnaire juridique français-italien, italien-français$e(Droit, finances, commerce, douanes, assurances, administration)$fMario Matteucci$gpréface par Jules Borsdevent 210 $aMilano$aParis$cGiuffrè$cDe Navarre$d1963 215 $a510 p.$d24 cm 300 $aFront. anche in italiano 410 0$12001 454 1$12001 461 1$1001-------$12001 606 0 $aDiritto$xDizionari francesi 676 $a340.0341 700 1$aMATTEUCCI,$bMario$0134466 702 1$aBORSDEVENT,$bJules 801 0$aIT$bsalbc$gISBD 912 $a990002258740203316 951 $aXXI.1. 38(340.03 MAT)$b7541 G.$cXXI.1. 959 $aBK 969 $aGIU 979 $aSIAV4$b10$c20041210$lUSA01$h1617 979 $aCOPAT3$b90$c20051130$lUSA01$h1344 979 $aPATRY$b90$c20140702$lUSA01$h1316 996 $aDictionnaire juridique français-italien, italien-français$91066430 997 $aUNISA LEADER 03041nam 2200529 450 001 9910823797803321 005 20230124195441.0 010 $a3-11-051504-0 010 $a3-11-051575-X 024 7 $a10.1515/9783110515756 035 $a(CKB)4100000002964631 035 $a(MiAaPQ)EBC5157812 035 $a(DE-B1597)472726 035 $a(OCoLC)1025395624 035 $a(DE-B1597)9783110515756 035 $a(Au-PeEL)EBL5157812 035 $a(CaPaEBR)ebr11566804 035 $a(EXLCZ)994100000002964631 100 $a20180621d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMacrolides $eproperties, synthesis and applications /$fBiljana Arsic [and five others] 210 1$aBerlin ;$aBoston :$cDe Gruyter,$d[2018] 215 $a1 online resource (112 pages) 311 $a3-11-051502-4 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tPreface -- $tContents -- $t1. The macrolide antibiotics and their semi-synthetic derivatives / $rArsic, Biljana / Barber, Jill / Novak, Predrag -- $t2. The semisynthetic routes towards better macrolide antibiotics / $rKragol, Goran -- $t3. Interactions of macrolides with their biological targets / $rNovak, Predrag -- $t4. Hybrids of macrolides and nucleobases or nucleosides: synthetic strategies and biological results / $rSodano, Federica / Rimoli, Maria Grazia -- $tIndex 330 $aMacrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance. 606 $aAntibacterial agents 606 $aMacrolide antibiotics 606 $aSCIENCE / Chemistry / Organic$2bisacsh 615 0$aAntibacterial agents. 615 0$aMacrolide antibiotics. 615 7$aSCIENCE / Chemistry / Organic. 676 $a615.7922 700 $aArsic$b Biljana, $01599985 702 $aArsic$b Biljana$f1980- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910823797803321 996 $aMacrolides$93922888 997 $aUNINA