LEADER 04964nam 2200649 a 450 001 9910823688003321 005 20240516164132.0 010 $a1-280-66943-8 010 $a9786613646361 010 $a981-4343-72-2 035 $a(CKB)2550000000101794 035 $a(EBL)919048 035 $a(OCoLC)775296617 035 $a(SSID)ssj0000655922 035 $a(PQKBManifestationID)12253256 035 $a(PQKBTitleCode)TC0000655922 035 $a(PQKBWorkID)10631002 035 $a(PQKB)10347468 035 $a(MiAaPQ)EBC919048 035 $a(WSP)00008123 035 $a(Au-PeEL)EBL919048 035 $a(CaPaEBR)ebr10563548 035 $a(CaONFJC)MIL364636 035 $a(EXLCZ)992550000000101794 100 $a20120611d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFibrocytes in health and disease /$fRichard Bucala 205 $a1st ed. 210 $aSingapore $cWorld Scientific Pub. Co.$d2012 215 $a1 online resource (335 p.) 300 $aDescription based upon print version of record. 311 $a981-4343-71-4 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; Contributors; Chapter 1. Hematopoietic Origin of Fibrocytes Mehrdad Abedi; 1.1. Introduction; 1.2. Structure of Bone Marrow; 1.3. Marrow-Derived Fibroblasts; 1.4. Origin of Fibroblasts in Tissue; 1.5. Fibrocytes; 1.6. What is the Relation between Macrophages and Circulating Fibroblasts Precursors?; 1.7. Perspective; References; Chapter 2. Fibrocytes and Collagen-Producing Cells of the Peripheral Blood Richard H. Gomer and Darrell Pilling; 2.1. Introduction: Fibrocytes Precursors Originate in Bone Marrow, and Exist in Blood 327 $a2.2. The Chemokine CXCL12 Attracts Circulating Fibrocyte Precursors to Sites of Injury2.3. Identification of Circulating CCPCs in the Blood; 2.4. Pulmonary Fibrosis Patients have Abnormally High Numbers of CCPCs; 2.5. Scleroderma Patients have Abnormally High Numbers of CCPCs; 2.6. Differences between CCPCs from Scleroderma Patients and Controls; 2.7. Patients with Chronic Asthma have Abnormally High Numbers of CCPCs; 2.8. CCPCs in Rheumatoid Arthritis Patients; 2.9. The Number of CCPCs Increases with Age; 2.10. The Number of CCPCs Increases in an Animal Injury Model 327 $a2.11. Summary and Future DirectionsAcknowledgements; References; Chapter 3. Regulatory Pathways of Fibrocyte Development Darrell Pilling and Richard H. Gomer; 3.1. Introduction; 3.2. Inhibition of Initial Fibrocyte Differentiation by Fc? Receptor Ligation; 3.3. Inhibition of Initial Fibrocyte Differentiation by Cytokines; 3.4. Profibrotic Cytokines Promote Fibrocyte Differentiation; 3.5. Regulation of Mature Fibrocyte Differentiation; References; Chapter 4. Fibrocyte Differentiation Pathways Ellen C. Keeley, Borna Mehrad and Robert M. Strieter; 4.1. Introduction 327 $a4.2. Fibrocyte Differentiation along Mesenchymal Lineages4.2.1. Myofibroblasts; 4.2.2. Adipocytes; 4.2.3. Osteoblasts and Chondrocytes; 4.3. Fibrocytes can be Reprogrammed to Modify the Fibroproliferative Response; 4.4. Factors that Influence Differentiation of Fibrocytes from their Precursors; 4.5. Conclusion; References; Chapter 5. Immunoregulation of Fibrocyte Differentiation Matthias Mack, Marianne Niedermeier and Barbara Reich; 5.1. Detection and Origin of Fibrocytes; 5.2. Interaction of Monocytes with CD4+ T Cells Enables Differentiation of Fibrocytes 327 $a5.3. Cytokines and CD4+ T Cell Phenotypes Regulate Fibrocyte Differentiation5.4. Influence of Serum on Fibrocyte Differentiation; 5.5. Proliferation of Fibrocytes?; 5.6. Migration of Fibrocytes; 5.7. How Fibrocytes Affect CD4+ T Cells; 5.8. Conclusion; References; Chapter 6. The Role of Fibrocytes in Wound Repair and Hypertrophic Scarring Abelardo Medina, Jie Ding, Moein Momtazi, and Edward E. Tredget; 6.1. Introduction; 6.2. Dysregulated Repair of the Extracellular Matrix of Hypertrophic Scars; 6.3. Dysregulated Apoptosis in Hypertrophic Scar 327 $a6.4. Increased Levels of the Profibrotic Growth Factors TGF-? and CTGF in Hypertrophic Scarring 330 $aThis volume provides a comprehensive and multidisciplinary overview of fibrocytes, written by the main researchers in the field. It is aimed at a broad audience of scientists and clinicians with an interest in the role of circulating fibrocytes in the etiopathogenesis of different fibrosing disorders, atherosclerosis, autoimmunity, and cancer. 606 $aFibroblasts 606 $aConnective tissues$xDiseases 615 0$aFibroblasts. 615 0$aConnective tissues$xDiseases. 676 $a611.0181 700 $aBucala$b Richard$098986 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910823688003321 996 $aFibrocytes in health and disease$93918952 997 $aUNINA