LEADER 04957nam 2200649Ia 450 001 9910823558603321 005 20240417005308.0 010 $a0-309-16335-8 010 $a1-282-91702-1 010 $a9786612917028 010 $a0-309-15333-6 035 $a(CKB)2560000000069604 035 $a(SSID)ssj0000443504 035 $a(PQKBManifestationID)11299723 035 $a(PQKBTitleCode)TC0000443504 035 $a(PQKBWorkID)10456032 035 $a(PQKB)11314061 035 $a(MiAaPQ)EBC3378704 035 $a(Au-PeEL)EBL3378704 035 $a(CaPaEBR)ebr10433659 035 $a(CaONFJC)MIL291702 035 $a(OCoLC)703252903 035 $a(EXLCZ)992560000000069604 100 $a20100826d2010 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTransforming clinical research in the United States $echallenges and opportunities : workshop summary /$fRebecca A. English, Yeanwoo Lebovitz, and Robert B. Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$dc2010 215 $axvii, 131 p. $cill. (some col.), col. maps 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-309-15332-8 320 $aIncludes bibliographical references (p. 103-105). 327 $aIntroduction -- The state of clinical research in the United States: an overview -- Challenges in clinical research -- Clinical trials in cardiovascular disease -- Clinical trials in depression -- Clinical trials in cancer -- Clinical trials in diabetes -- Building a robust clinical trials infrastructure. 330 $a"An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls far short of this vision. The process of generating medical evidence through clinical trials in the United States is expensive and lengthy, includes a number of regulatory hurdles, and is based on a limited infrastructure. The link between clinical research and medical progress is also frequently misunderstood or unsupported by both patients and providers. The focus of clinical research changes as diseases emerge and new treatments create cures for old conditions. As diseases evolve, the ultimate goal remains to speed new and improved medical treatments to patients throughout the world. To keep pace with rapidly changing health care demands, clinical research resources need to be organized and on hand to address the numerous health care questions that continually emerge. Improving the overall capacity of the clinical research enterprise will depend on ensuring that there is an adequate infrastructure in place to support the investigators who conduct research, the patients with real diseases who volunteer to participate in experimental research, and the institutions that organize and carry out the trials. To address these issues and better understand the current state of clinical research in the United States, the Institute of Medicine's (IOM) Forum on Drug Discovery, Development, and Translation held a 2-day workshop entitled Transforming Clinical Research in the United States. The workshop, summarized in this volume, laid the foundation for a broader initiative of the Forum addressing different aspects of clinical research. Future Forum plans include further examining regulatory, administrative, and structural barriers to the effective conduct of clinical research; developing a vision for a stable, continuously funded clinical research infrastructure in the United States; and considering strategies and collaborative activities to facilitate more robust public engagement in the clinical research enterprise."--Publisher's description. 606 $aClinical trials$zUnited States$vCongresses 606 $aClinical trials$xResearch$zUnited States$vCongresses 606 $aClinical trials$xGovernment policy$zUnited States$vCongresses 615 0$aClinical trials 615 0$aClinical trials$xResearch 615 0$aClinical trials$xGovernment policy 676 $a610.72/4 701 $aEnglish$b Rebecca A$01602351 701 $aLebovitz$b Yeonwoo$01635709 701 $aGiffin$b Robert B$01653478 712 02$aInstitute of Medicine (U.S.).$bForum on Drug Discovery, Development, and Translation. 712 02$aNational Academies Press (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910823558603321 996 $aTransforming clinical research in the United States$94072736 997 $aUNINA