LEADER 07186nam 22013213u 450 001 9910823465003321 005 20240516134414.0 010 $a1-280-87984-X 010 $a9786613721150 010 $a1-118-34230-5 010 $a1-118-34231-3 010 $a1-118-34228-3 035 $a(CKB)2670000000207504 035 $a(EBL)875926 035 $a(OCoLC)781432694 035 $a(SSID)ssj0000677002 035 $a(PQKBManifestationID)11399726 035 $a(PQKBTitleCode)TC0000677002 035 $a(PQKBWorkID)10693926 035 $a(PQKB)11594930 035 $a(MiAaPQ)EBC875926 035 $a(EXLCZ)992670000000207504 100 $a20131014d2012|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCholesterol Regulation of Ion Channels and Receptors$b[electronic resource] 205 $a1st ed. 210 $aHoboken $cWiley$d2012 215 $a1 online resource (324 p.) 300 $aDescription based upon print version of record. 311 $a0-470-87432-5 327 $aCHOLESTEROL REGULATION OF ION CHANNELS AND RECEPTORS; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES; 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.1 CHOLESTEROL-AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION; 1.2 CHOLESTEROL METABOLISM, SENSING, AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.3 HOW DOES CHOLESTEROL ENTER MAMMALIAN CELLS?; 1.4 VESICULAR CHOLESTEROL TRAFFICKING ALONG THE ENDOCYTIC AND SECRETORY PATHWAY; 1.5 NONVESICULAR CHOLESTEROL TRANSPORT; 1.6 CHOLESTEROL EFFLUX FROM CELLS; REFERENCES 327 $a2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES-AN ENERGETIC PERSPECTIVE2.1 INTRODUCTION; 2.2 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS: POSSIBLE MECHANISMS; 2.3 PROTEIN REGULATION BY CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.4 CHOLESTEROL-INDUCED CHANGES IN DGIII bilayer - QUANTITATIVE ESTIMATES; 2.5 METHODS FOR IDENTIFYING PROTEIN REGULATION BY CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.6 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS IN LIVING CELLS 327 $a2.7 PHYSIOLOGICAL ROLE OF CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES2.8 CONCLUSION; REFERENCES; II CHOLESTEROL REGULATION OF ION CHANNELS; 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS; 3.1 INTRODUCTION; 3.2 CHOLESTEROL SUPPRESSES Kir2 ACTIVITY IN VITRO AND IN VIVO; 3.3 EVIDENCE FOR SPECIFIC STEROL-PROTEIN INTERACTIONS IN THE REGULATION OF Kir CHANNELS; 3.4 STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF Kir2 CHANNELS; 3.5 PHYSIOLOGICAL IMPACT OF CHOLESTEROL-INDUCED SUPPRESSION OF KIR2 CHANNELS 327 $a3.6 CONCLUDING REMARKS AND FUTURE DIRECTIONSACKNOWLEDGMENTS; REFERENCES; 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS; 4.1 INTRODUCTION; 4.2 MOLECULAR COMPONENTS OF SOCE; 4.3 LIPID RAFT DOMAINS AND CAVEOLAE; 4.4 THE ROLE OF LIPID RAFT DOMAINS IN THE REGULATION OF TRPC1; 4.5 MOLECULAR COMPLEXITY IN THE REGULATION OF SOCE; 4.6 CONCLUSIONS; REFERENCES; 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS; 5.1 INTRODUCTION; 5.2 EFFECT OF CHOLESTEROL ON CARDIAC EXCITABILITY; 5.3 MECHANISMS OF CHOLESTEROL EFFECTS ON ION CHANNELS 327 $a5.4 CHOLESTEROL AS A TARGET FOR THERAPEUTIC AGENTSREFERENCES; 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS; 6.1 BK CHANNELS AND STEROIDS; 6.2 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM; 7.1 POTASSIUM CHANNELS IN THE IMMUNE SYSTEM; 7.2 REGULATION OF POTASSIUM CHANNELS BY MEMBRANE CHOLESTEROL AND LIPID RAFT MICRODOMAINS; 7.3 LOCALIZATION OF MAJOR VOLTAGE-DEPENDENT Kv1.3 AND Kv1.5 CHANNELS IN CHOLESTEROL-RICH MEMBRANE MICRODOMAINS IN LEUKOCYTES 327 $a7.4 MECHANISMS OF ION CHANNEL REGULATION: THE IMMUNOLOGICAL SYNAPSE 330 $aExamines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagatio 606 $aCholesterol - metabolism 606 $aCholesterol -- metabolism 606 $aIon Channels - metabolism 606 $aIon Channels -- metabolism 606 $aMembrane Proteins - metabolism 606 $aMembrane Proteins -- metabolism 606 $aCholesterol$xMetabolism 606 $aIon channels$xMetabolism 606 $aMembrane proteins$xMetabolism 606 $aProteins 606 $aMembrane Glycoproteins 606 $aSterols 606 $aMembrane Transport Proteins 606 $aMetabolic Phenomena 606 $aCholestenes 606 $aAmino Acids, Peptides, and Proteins 606 $aCarrier Proteins 606 $aCholestanes 606 $aMembrane Lipids 606 $aLipids 606 $aSteroids 606 $aDrugs 606 $aPolycyclic Compounds 606 $aCholesterol 606 $aIon Channels 606 $aMetabolism 606 $aMembrane Proteins 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 606 $aAnimal Biochemistry$2HILCC 615 4$aCholesterol - metabolism. 615 4$aCholesterol -- metabolism. 615 4$aIon Channels - metabolism. 615 4$aIon Channels -- metabolism. 615 4$aMembrane Proteins - metabolism. 615 4$aMembrane Proteins -- metabolism. 615 0$aCholesterol$xMetabolism 615 0$aIon channels$xMetabolism 615 0$aMembrane proteins$xMetabolism 615 2$aProteins 615 2$aMembrane Glycoproteins 615 2$aSterols 615 2$aMembrane Transport Proteins 615 2$aMetabolic Phenomena 615 2$aCholestenes 615 2$aAmino Acids, Peptides, and Proteins 615 2$aCarrier Proteins 615 2$aCholestanes 615 2$aMembrane Lipids 615 2$aLipids 615 2$aSteroids 615 2$aDrugs 615 2$aPolycyclic Compounds 615 2$aCholesterol 615 2$aIon Channels 615 2$aMetabolism 615 2$aMembrane Proteins 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 615 7$aAnimal Biochemistry 676 $a572.5795 676 $a612.1/2 676 $a612.12 700 $aLevitan$b Irena$01593947 701 $aBarrantes$b Francisco$01593948 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910823465003321 996 $aCholesterol Regulation of Ion Channels and Receptors$93914318 997 $aUNINA