LEADER 03775nam 2200661Ia 450 001 9910823074603321 005 20200520144314.0 010 $a1-281-14091-0 010 $a9786611140915 010 $a3-7643-8296-1 024 7 $a10.1007/978-3-7643-8296-4 035 $a(CKB)1000000000404035 035 $a(EBL)338156 035 $a(OCoLC)370727597 035 $a(SSID)ssj0000176883 035 $a(PQKBManifestationID)11179978 035 $a(PQKBTitleCode)TC0000176883 035 $a(PQKBWorkID)10206484 035 $a(PQKB)11246757 035 $a(DE-He213)978-3-7643-8296-4 035 $a(MiAaPQ)EBC338156 035 $a(Au-PeEL)EBL338156 035 $a(CaPaEBR)ebr10221629 035 $a(CaONFJC)MIL114091 035 $a(PPN)123740274 035 $a(EXLCZ)991000000000404035 100 $a20070731d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe immune synapse as a novel target for therapy /$fLuis Graca, editor 205 $a1st ed. 2008. 210 $aBasel $cBirkhauser$dc2008 215 $a1 online resource (203 p.) 225 1 $aPIR (Series) 300 $a"Progress in inflammation research". 311 $a3-7643-8295-3 320 $aIncludes bibliographical references and index. 327 $aThe immune synapse and T cell activation: regulation by chemokines -- The induction of regulatory T cells by targeting the immune synapse -- Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology -- Targeting CD4 for the induction of dominant tolerance -- Anti-CD3: from T cell depletion to tolerance induction -- Immune modulation by CD40L blockade -- CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance -- Adhesion molecules as therapeutic targets -- E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within? -- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells -- Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance -- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic. 330 $aThe immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell?APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogram the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as those targeting the lymphocyte co-receptor, costimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, LFA-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy. This volume discusses the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It is of interest to clinicians and researchers working in this area. 410 0$aPIR (Series) 606 $aImmune response$xMolecular aspects 606 $aImmune response$xRegulation 606 $aSynapses 615 0$aImmune response$xMolecular aspects. 615 0$aImmune response$xRegulation. 615 0$aSynapses. 676 $a616.079 701 $aGraca$b Luis$cMD.$0678504 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910823074603321 996 $aThe Immune Synapse as a Novel Target for Therapy$93997033 997 $aUNINA