LEADER 05250nam 2200757 a 450 001 9910823053703321 005 20240516145513.0 010 $a1-283-62774-4 010 $a3-11-025877-3 010 $a9786613940193 024 7 $a10.1515/9783110258776 035 $a(CKB)3360000000446089 035 $a(EBL)893470 035 $a(SSID)ssj0000720578 035 $a(PQKBManifestationID)12314900 035 $a(PQKBTitleCode)TC0000720578 035 $a(PQKBWorkID)10669443 035 $a(PQKB)11367686 035 $a(MiAaPQ)EBC893470 035 $a(DE-B1597)124093 035 $a(OCoLC)1046616346 035 $a(OCoLC)1047015769 035 $a(OCoLC)1049633945 035 $a(OCoLC)1054881669 035 $a(OCoLC)775848015 035 $a(OCoLC)817558102 035 $a(DE-B1597)9783110258776 035 $a(Au-PeEL)EBL893470 035 $a(CaPaEBR)ebr10606388 035 $a(CaONFJC)MIL394019 035 $a(EXLCZ)993360000000446089 100 $a20120509d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aExtracellular matrix $epathobiology and signaling /$fedited by Nikos K. Karamanos 205 $a1st ed. 210 $aBerlin $cWalter de Gruyter$dc2012 215 $a1 online resource (940 p.) 300 $aDescription based upon print version of record. 311 $a3-11-025876-5 320 $aIncludes bibliographical references and index. 327 $aAn introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis ... [et al.] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos. 330 $aOver the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting.It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden 330 $aOver the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting. 606 $aExtracellular matrix 606 $aCellular signal transduction 610 $aBiochemistry. 610 $aCollagens. 610 $aGlycans. 610 $aMatrix. 610 $aMetalloproteinases. 615 0$aExtracellular matrix. 615 0$aCellular signal transduction. 676 $a611/.0182 686 $aWE 3900$2rvk 701 $aKaramanos$b Nikos K$01711555 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910823053703321 996 $aExtracellular matrix$94102950 997 $aUNINA