LEADER 03154nam 2200661 450 001 9910822425603321 005 20230803220216.0 010 $a0-19-934366-7 010 $a0-19-992754-5 035 $a(CKB)2550000001123581 035 $a(EBL)1481007 035 $a(OCoLC)861559220 035 $a(SSID)ssj0001001147 035 $a(PQKBManifestationID)11643061 035 $a(PQKBTitleCode)TC0001001147 035 $a(PQKBWorkID)10966048 035 $a(PQKB)10495523 035 $a(StDuBDS)EDZ0000204026 035 $a(MiAaPQ)EBC1481007 035 $a(Au-PeEL)EBL1481007 035 $a(CaPaEBR)ebr10775462 035 $a(CaONFJC)MIL525298 035 $a(OCoLC)859536749 035 $a(EXLCZ)992550000001123581 100 $a20130426h20142014 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFemales are mosaics $eX inactivation and sex differences in disease /$fBarbara R. Migeon 205 $aSecond edition. 210 1$aOxford :$cOxford University Press,$d[2014] 210 4$dİ2014 215 $a1 online resource (328 p.) 300 $aDescription based upon print version of record. 311 $a0-19-992753-7 311 $a1-299-94047-1 320 $aIncludes bibliographical references and index. 327 $aSex differences in disease -- Evolution of the human sex chromosomes and a portrait of the human X -- X chromosome dosage compensation : an overview -- The discovery of X chromosome inactivation -- Experimental models for X inactivation studies -- Theme 1 : the initial step : creating the active and inactive X -- Theme 2 : subsequent steps : spreading and maintaining inactivation -- Variations 1 : evolution of the X inactivation center -- Variations 2 : stability of the inactive X -- Variations 3 : choice of active X -- The single active X -- Mosaicism -- Epimutations, chromatin disorders and sex differences in phenotype -- Determinants of female phenotypes. 330 $aWomen can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome, females have two X chromosomes in every cell. Much has been written about the Y chromosome and its role in inducing maleness. This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. This new edition reflects research advances from the six years since the widely praised first edition. New advances include knowledge of species 606 $aMosaicism 606 $aX chromosome$xAbnormalities 606 $aGenetic disorders 606 $aSex factors in disease 615 0$aMosaicism. 615 0$aX chromosome$xAbnormalities. 615 0$aGenetic disorders. 615 0$aSex factors in disease. 676 $a616/.042 700 $aMigeon$b Barbara R$01646546 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910822425603321 996 $aFemales are mosaics$93993606 997 $aUNINA