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100   $a20121206d2014      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aMetal-based neurodegeneration $efrom molecular mechanisms to therapeutic strategies /$fRobert Crichton and Roberta Ward
205   $aSecond edition.
210  1$aChichester, West Sussex, U.K. :$cWiley,$d2014.
215   $a1 online resource (439 p.)
300   $aDescription based upon print version of record.
311   $a1-119-97714-2 
311   $a1-299-84895-8 
320   $aIncludes bibliographical references and index.
327   $aBrain function, physiology, and the blood-brain barrier -- Role of metal ions in brain function, metal transport, storage, and homeostasis -- Immune system and neuroinflammation -- Oxidative stress in neurodegenerative diseases -- Aging and mild cognitive impairment, MCI -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotropic lateral sclerosis -- Alcoholic brain damage -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurological diseases.
330   $aNeurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.  Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scient
606   $aBrain$xPathophysiology
606   $aMetals$xHealth aspects
606   $aNervous system$xDegeneration$xEtiology
606   $aOxidative stress
615  0$aBrain$xPathophysiology.
615  0$aMetals$xHealth aspects.
615  0$aNervous system$xDegeneration$xEtiology.
615  0$aOxidative stress.
676   $a616.8/0471
700   $aCrichton$b Robert R$0520760
701   $aWard$b Roberta J$01687622
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910822397703321
996   $aMetal-based neurodegeneration$94061235
997   $aUNINA