LEADER 04281nam 22006374a 450 001 9910821997503321 005 20200520144314.0 010 $a1-280-36785-7 010 $a9780471531995 010 $a9786610367856 010 $a0-470-34293-5 010 $a0-471-53199-5 010 $a0-471-53197-9 035 $a(CKB)111087027117256 035 $a(EBL)470024 035 $a(OCoLC)54360519 035 $a(SSID)ssj0000102910 035 $a(PQKBManifestationID)11138337 035 $a(PQKBTitleCode)TC0000102910 035 $a(PQKBWorkID)10061033 035 $a(PQKB)10262394 035 $a(MiAaPQ)EBC470024 035 $a(Au-PeEL)EBL470024 035 $a(CaPaEBR)ebr10114048 035 $a(CaONFJC)MIL36785 035 $a(EXLCZ)99111087027117256 100 $a20030625d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAnalysis and purification methods in combinatorial chemistry /$fedited by Bing Yan 205 $a1st ed. 210 $aHoboken, N.J. $cWiley-Interscience$d2004 215 $a1 online resource (xiii, 466 pages) $cillustrations 225 1 $aChemical analysis ;$vv. 163 300 $aDescription based upon print version of record. 311 0 $a0-471-26929-8 320 $aIncludes bibliographical references and index. 327 $aAnalysis and Purification Methods in Combinatorial Chemistry; CONTENTS; PREFACE; CONTRIBUTORS; PART I ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS; CHAPTER 1 QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR SPECTROSCOPY; CHAPTER 2 (19)F GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING; CHAPTER 3 THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS; CHAPTER 4 HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTS 327 $aCHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS; CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT; PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL; CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL LIBRARY ANALYSIS; CHAPTER 8 MICELLAR ELECTROKINETIC CHROMATOGRAPHY AS A TOOL FOR COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS; CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL LIBRARIES; PART III HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY 327 $aCHAPTER 10 STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS AND COMBINATORIAL LIBRARIES; CHAPTER 11 HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION; CHAPTER 12 PARALLEL HPLC IN HIGH-THROUGHPUT ANALYSIS AND PURIFICATION; PART IV ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY; CHAPTER 13 ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL SCREENING COLLECTION; CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION; CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL PROFILING: POTENTIAL AND LIMITATIONS; CHAPTER 16 SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES; CHAPTER 17 HIGH-THROUGHPUT DETERMINATION OF LOG D VALUES BY LC/MS METHODINDEX 330 $aQuality measurement, control, and improvement in combinatorial chemistryCombinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are ""purifiable,"" and ""drugable.""To this end, Analysis and Purification Methods in Combinatorial Chemistry 410 0$aChemical analysis ;$vv. 163. 606 $aCombinatorial chemistry 615 0$aCombinatorial chemistry. 676 $a615/.19 701 $aYan$b Bing$0366894 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910821997503321 996 $aAnalysis and purification methods in combinatorial chemistry$94192163 997 $aUNINA