LEADER 05353nam 2200673 450 001 9910821663403321 005 20200520144314.0 010 $a3-527-66693-1 010 $a3-527-66691-5 010 $a3-527-66694-X 035 $a(CKB)2550000001115765 035 $a(EBL)1372258 035 $a(OCoLC)857970041 035 $a(SSID)ssj0001164524 035 $a(PQKBManifestationID)11686291 035 $a(PQKBTitleCode)TC0001164524 035 $a(PQKBWorkID)11181867 035 $a(PQKB)11275843 035 $a(MiAaPQ)EBC1372258 035 $a(MiAaPQ)EBC4044473 035 $a(Au-PeEL)EBL1372258 035 $a(CaPaEBR)ebr10756557 035 $a(CaONFJC)MIL516100 035 $a(PPN)19970189X 035 $a(EXLCZ)992550000001115765 100 $a20130919h20142014 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNatural lactones and lactams $esynthesis, occurrence and biological activity /$fedited by Tomasz Janecki 210 1$aWeinheim, Germany :$cWiley-VCH Verlag GmbH & Co. KGaA,$d[2014] 210 4$dİ2014 215 $a1 online resource (394 p.) 300 $aDescription based upon print version of record. 311 $a3-527-33414-9 311 $a1-299-84849-4 320 $aIncludes bibliographical references and index. 327 $aNatural Lactones and Lactams; Title Page; Copyright; Contents; Preface; List of Contributors; Chapter 1 Tetronic Acids; 1.1 Introduction; 1.2 Natural Occurrence, Biological Activities, and Biosynthesis; 1.3 5-Ylidene Tetronic Natural Products; 1.3.1 Pulvinic Acids and Pulvinones; 1.3.2 Agglomerins; 1.3.3 Tetronomycin; 1.3.4 Stemofoline Alkaloids; 1.3.5 Variabilin; 1.3.6 Tetrodecamycin; 1.4 5-Monosubstituted Tetronic Natural Products; 1.4.1 Carlic, Carlosic, Carolic, Carolinic, and Viridicatic Acids; 1.4.2 RK-682; 1.4.3 Massarilactone B; 1.4.4 Annularins F, G, and H; 1.4.5 Palinurin 327 $a1.4.6 Pesthetoxin1.4.7 Rotundifolides A and B; 1.5 5-Disubstituted Tetronic Natural Products; 1.5.1 5-Dialkyl Tetronic Natural Products; 1.5.1.1 Vertinolide; 1.5.1.2 Papyracillic Acid B; 1.5.1.3 Bisorbibutenolide; 1.5.2 5-Spirotetronic Natural Products; 1.5.2.1 Spirotetronic Antibiotics; 1.5.2.2 Ircinianin and Wistarin; 1.5.2.3 Stemonamine Alkaloids; 1.5.2.4 Abyssomicins; 1.6 5-Unsubstituted Tetronic Natural Products; 1.6.1 Tetronasin; 1.7 Conclusions; References; Chapter 2 Recent Advances in the Field of Naturally Occurring 5,6-Dihydropyran-2-ones; 2.1 Introduction 327 $a2.2 Synthetic Methodologies for 5,6-Dihydropyran-2-ones2.2.1 Lactonization of Substituted ?-Hydroxy Acid Derivatives; 2.2.2 Oxidation of Substituted Dihydropyran Derivatives; 2.2.3 Ring-Closing Metathesis; 2.2.4 Miscellaneous Methods; 2.3 Formation of Stereogenic Centers inside the Dihydropyrone Ring; 2.3.1 Use of Chiral Precursors; 2.3.1.1 Carbohydrate and Related Precursors; 2.3.1.2 Chiral Hydroxy Acids; 2.3.1.3 Chiral Epoxides; 2.3.1.4 Other Chirons; 2.3.2 Asymmetric (Enantioselective) Reactions; 2.3.2.1 Asymmetric (Enantioselective) Sharpless Epoxidations or Dihydroxylations 327 $a2.3.2.2 Asymmetric Aldol-Type Reactions2.3.2.3 Asymmetric Allylations; 2.3.2.4 Asymmetric Carbonyl Reductions; 2.3.2.5 Asymmetric Alkylations; 2.3.2.6 Asymmetric Epoxide Hydrolysis; 2.3.2.7 Asymmetric Cycloadditions; 2.3.2.8 Other Asymmetric Methods; 2.4 Pharmacological Properties of Pyrones; 2.5 Biosynthetic Formation of Pyrones; 2.6 Syntheses of Natural 5,6-Dihydropyran-2-ones Reported during the Period from 2006 to the First Half of 2012; References; Chapter 3 ?-Lactams; 3.1 Introduction; 3.1.1 Biosynthesis of Penicillin and Cephalosporin; 3.2 Monocyclic ?-Lactams 327 $a3.2.1 Biosynthesis of Nocardicin A3.2.2 Synthetic Approaches to Construct ?-Lactam Ring; 3.2.2.1 Cycloaddition Reactions; 3.2.2.2 Cyclization Reactions; 3.2.2.3 Miscellaneous Approaches; 3.2.3 Biological Activity of Monocyclic 2-Azetidinones; 3.3 Penams; 3.3.1 Synthetic Approaches to Penam Skeleton; 3.3.2 Biological Activity of Penams; 3.4 Cephalosporins; 3.4.1 Synthetic Approaches to Cephalosporin Skeleton; 3.4.2 Biological Activity of Cephalosporins; 3.5 Clavulanic Acid; 3.5.1 Synthetic Approaches to Clavam Skeleton; 3.5.2 Biological Activity of Clavams; 3.6 Carbapenems 327 $a3.6.1 Synthetic Approaches to Carbapenem Skeleton 330 $aWhile there are numerous books on heterocycles and natural products, this text fills the need for an up-to-date summary focusing on recently developed and improved synthetic methods for the preparation of the most important classes of lactones and lactams - all in one volume. Comprehensive in its coverage, this book also provides readers with a brief description of the occurrence and biological or pharmaceutical activity of the compounds, and each chapter deals with a certain class of lactones or lactames to enable quick access to the information needed.A valuable resource for orga 606 $aLactones 606 $aLactams 615 0$aLactones. 615 0$aLactams. 676 $a547.59 701 $aJanecki$b Tomasz$01611126 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910821663403321 996 $aNatural lactones and lactams$93939196 997 $aUNINA