LEADER 04852nam 2200565 450 001 9910821460103321 005 20230808205324.0 010 $a3-527-80448-X 010 $a3-527-80447-1 010 $a3-527-80449-8 035 $a(CKB)4330000000010804 035 $a(EBL)4635125 035 $a(MiAaPQ)EBC4635125 035 $a(Au-PeEL)EBL4635125 035 $a(CaPaEBR)ebr11246588 035 $a(CaONFJC)MIL949761 035 $a(OCoLC)956706494 035 $a(EXLCZ)994330000000010804 100 $a20160831h20162016 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aAsymmetric synthesis of non-proteinogenic amino acids /$fAshot S. Saghyan and Peter Langer 210 1$aWeinheim, Germany :$cWiley-VCH,$d2016. 210 4$dİ2016 215 $a1 online resource (376 p.) 300 $aDescription based upon print version of record. 311 $a3-527-34041-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover ; Title Page ; Copyright ; Contents ; List of Abbreviations ; Introduction ; Chapter 1 Non-Proteinogenic -Amino Acids, Natural Origin, Biological Functions; References ; Part I Natural Synthesis of Amino Acids, Mechanisms, and Modeling; References ; Chapter 2 Some Regularities of Mechanisms for the Natural Synthesis of Amino Acids ; References 327 $aChapter 3 Systems for Modeling Some Aspects of Pyridoxal Enzyme Action References ; Chapter 4 Modeling of Processes Associated with Cleavage of C -H and C -C Bonds; References ; Chapter 5 Modeling of , -Elimination Processes of PP-Catalysis, Kinetics, and Stereochemistry; References 327 $aChapter 6 Biomimetic Addition Reaction of Nucleophiles to CoIII Complexes of Dehydroaminobutyric Acid References ; Part II Asymmetric Synthesis of Nonprotein -Amino Acids; Chapter 7 The Main Rules of Asymmetric Synthesis ; References ; Chapter 8 Catalytic Asymmetric Synthesis 327 $a8.1 Achiral NiII Complexes of Schiff Bases of Amino Acids 8.1.1 The Alkylation of Achiral NiII Complexes Under Phase-Transfer Catalysis ; 8.1.2 Reactions of 1,4-Michael Addition to Achiral Glycine and Dehydroalanine Complexes ; 8.1.3 Synthesis of Enantiomerically Enriched -Amino Acids 327 $a8.1.3.1 The Asymmetric Alkylation of Substrate 65a by Alkyl Halides Under Phase-Transfer Catalysis 8.1.3.2 Asymmetric Aldol Condensation of Achiral NiII Complexes of Amino Acids ; 8.1.3.3 The Asymmetric Michael Addition of Achiral NiII Substrates to Electron-Withdrawing Compounds 327 $a8.1.3.4 Catalytic Asymmetric Addition of Nucleophiles to an Achiral Dehydroalanine Substrate 330 $aAuthored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology. 606 $aAmino acids$xSynthesis 615 0$aAmino acids$xSynthesis. 676 $a547.750459 700 $aSaghyan$b Ashot S.$01604097 702 $aLanger$b Peter 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910821460103321 996 $aAsymmetric synthesis of non-proteinogenic amino acids$93928774 997 $aUNINA