LEADER 04343nam 2200697 450 001 9910821258703321 005 20220809213856.0 010 $a0-8157-2638-4 035 $a(CKB)2670000000570547 035 $a(EBL)1793978 035 $a(SSID)ssj0001378308 035 $a(PQKBManifestationID)11726659 035 $a(PQKBTitleCode)TC0001378308 035 $a(PQKBWorkID)11329913 035 $a(PQKB)10019707 035 $a(OCoLC)897560732 035 $a(MdBmJHUP)muse40156 035 $a(Au-PeEL)EBL1793978 035 $a(CaPaEBR)ebr10951819 035 $a(CaONFJC)MIL650373 035 $a(OCoLC)893708610 035 $a(MiAaPQ)EBC1793978 035 $a(PPN)193365642 035 $a(EXLCZ)992670000000570547 100 $a20141014h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe transformation of the American political party system$b[electronic resource] $econtinuity and change over ten presidential elections /$fJohn S. Jackson 210 1$aWashington, District of Columbia :$cBrookings Institution Press,$d2015. 210 4$dİ2015 215 $a1 online resource (257 p.) 300 $aDescription based upon print version of record. 311 $a0-8157-2637-6 311 $a1-322-19093-3 320 $aIncludes bibliographical references and index. 327 $aIntroduction and plan of the book -- Recent history of change and reform : the micro trends -- The era of party reform -- On representation -- On political values -- Comparison of political elites to the mass base of the parties -- Party and political history of the party elites -- The candidate and party factions -- Summary and conclusions. 330 $aFrom party polarization, elections, and internal party politics, to the evolution of the U.S. presidency, John S. Jackson's new book has something for everyone interested in American politics. Beginning with a discussion of the creation of the U.S. government to the formation of today's political powerhouses, Jackson provides a narrative sweep of American party history like none other. Unique to this book is a detailed breakdown of the evolution of political parties from 1832 to the current era. Jackson explains how the reform era came to be, as well as how it produced the polarized party era we have today. In doing so, he guides the reader to an appreciation of where U.S. party politics originated and the aspirations of those who helped create the current system. Jackson also examines the internal mechanisms and personalities of the Democratic and Republican parties. He compares multiple presidential elections, thus telling a broader story of the unfolding of today's party polarization and gridlock. He also explores the theoretical meaning of the changes observed in the parties from the responsible party model perspective .The themes of continuity and change are set in the context of group-think versus rational decision making. Specific focus is given to political elites who are sophisticated about politics and who make strategic decisions, but are also bound by their humanity and occasionally fail to see the right decision due to their own personal biases. This book will be particularly useful for those who want to explore polarization, the responsible parties model, the rational actor model, and anyone who wants to better understand elections, party politics, and the evolution of the presidency. 606 $aPolitical parties$zUnited States$xHistory 606 $aTwo-party systems 606 $aPolitical conventions$zUnited States$xHistory 606 $aPresidents$xNomination 606 $aPresidents$zUnited States$xElection$xHistory 606 $aPolitical culture$zUnited States$xHistory 615 0$aPolitical parties$xHistory. 615 0$aTwo-party systems. 615 0$aPolitical conventions$xHistory. 615 0$aPresidents$xNomination. 615 0$aPresidents$xElection$xHistory. 615 0$aPolitical culture$xHistory. 676 $a324.273 700 $aJackson$b John S.$f1940-$01615921 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910821258703321 996 $aThe transformation of the American political party system$93959370 997 $aUNINA LEADER 04944nam 2201501z- 450 001 9910557669103321 005 20220111 035 $a(CKB)5400000000044814 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76949 035 $a(oapen)doab76949 035 $a(EXLCZ)995400000000044814 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aUnderstanding Neuromuscular Health and Disease: Advances in Genetics, Omics, and Molecular Function 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (318 p.) 311 08$a3-0365-1622-0 311 08$a3-0365-1621-2 330 $aThis compilation focuses on recent advances in the molecular and cellular understandingof neuromuscular biology, and the treatment of neuromuscular disease.These advances are at the forefront of modern molecular methodologies, oftenintegrating across wet-lab cell and tissue models, dry-lab computational approaches,and clinical studies. The continuing development and application ofmultiomics methods offer particular challenges and opportunities in the field,not least in the potential for personalized medicine. 517 $aUnderstanding Neuromuscular Health and Disease 606 $aResearch & information: general$2bicssc 610 $a-omics approaches 610 $aAAV 610 $aadult patients 610 $aALS 610 $aALS genes 610 $aALS pathology 610 $aALS variants 610 $aAmyotrophic Lateral Sclerosis 610 $aautophagy 610 $aaxonal transport 610 $aBecker muscular dystrophy 610 $abecker muscular dystrophy (BMD) 610 $abiomarkers 610 $acalprotectin 610 $aCanadian Neuromuscular Disease Registry 610 $aclinical trials 610 $acomparative genomic hybridization array (CGH) 610 $acorticosteroids 610 $aCRISPR-Cas9 610 $aD4Z4 610 $adeflazacort 610 $adisease heterogeneity 610 $adisease models 610 $adisease modifiers 610 $aDMARD 610 $aDMD 610 $aDuchenne muscular dystrophy 610 $aduchenne muscular dystrophy (DMD) 610 $aDuchenne muscular dystrophy (DMD) 610 $aDUX4 610 $adystrophin 610 $adystrophinopathy 610 $adystrophy 610 $aEmery-Dreifuss muscular dystrophy 610 $aendocytosis 610 $aepigenetic changes 610 $aeteplirsen 610 $aexcitotoxicity 610 $aexon skipping 610 $aexon skipping therapy 610 $aexon-skipping therapies 610 $afacioscapulohumeral dystrophy 610 $aFSHD 610 $afunctional outcomes 610 $agene editing 610 $agene prioritization 610 $agene therapy 610 $agenetic neuromuscular disorders 610 $agenome-wide association studies 610 $agenomics 610 $agenotype-phenotype 610 $agenotype-phenotype correlations 610 $aglucocorticoids 610 $agolodirsen 610 $aGWAS 610 $aLMNA 610 $amachine learning 610 $amethotrexate 610 $amiRNA 610 $amitochondria dysfunction 610 $aMND 610 $amultiple logistic regression analysis 610 $amultiplex ligation probe amplification (MLPA) 610 $amultiplex polymerase chain reaction (PCR) 610 $amuscle 610 $an/a 610 $aneuromuscular diseases 610 $anext-generation sequencing (NGS) 610 $aNusinersen 610 $aOmics 610 $aoxidative stress 610 $apharmacodynamic biomarkers 610 $apharmacogenomics 610 $apolyadenylation 610 $aprecision medicine 610 $aprednisone 610 $aproteomics 610 $areading frame rule 610 $aregulation 610 $arheumatoid arthritis 610 $aRNA metabolism 610 $asafety 610 $aSanger sequencing 610 $asecretion 610 $askip-equivalent deletions 610 $aSMA 610 $aSNP 610 $aspinal muscular atrophy 610 $aTALEN 610 $atoxicity 610 $atranscription 610 $atranslational research 610 $aviltolarsen 610 $aXLMTM 615 7$aResearch & information: general 700 $aDuddy$b William$4edt$01323704 702 $aDuguez$b Stephanie$4edt 702 $aDuddy$b William$4oth 702 $aDuguez$b Stephanie$4oth 906 $aBOOK 912 $a9910557669103321 996 $aUnderstanding Neuromuscular Health and Disease: Advances in Genetics, Omics, and Molecular Function$93035745 997 $aUNINA