LEADER 03030nam 22004813 450 001 9910821246003321 005 20230227212801.0 010 $a0-309-30408-3 035 $a(CKB)4520000000000939 035 $a(MiAaPQ)EBC3564299 035 $a(MiAaPQ)EBC30205696 035 $a(Au-PeEL)EBL30205696 035 $a(NjHacI)994520000000000939 035 $a(EXLCZ)994520000000000939 100 $a20230227d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Emerging Field of Human Neural Organoids, Transplants, and Chimeras $eScience, Ethics, and Governance 205 $a1st ed. 210 1$aWashington, D.C. :$cNational Academies Press,$d2021. 210 4$dİ2021. 215 $a1 online resource (153 pages) 311 $a0-309-30336-2 327 $aFront Matter -- Summary -- 1. Introduction -- 2. The Science of Human Neural Organoids, Transplants, and Chimeras -- 3. Ethical Concerns -- 4. Oversight and Governance -- 5. Public Engagement -- 6. Findings of the Committee -- References -- Appendix A: Biographies of Committee and Staff Members -- Appendix B: Committee Meeting Agendas. 330 $aEach year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely lacking or only partially effective, due in large part to the difficulty of conducting brain research and the complexity of the brain itself. Researchers in recent years have developed new models to better represent and study the human brain. The three models considered in this report, all of which generate and use pluripotent stem cells from healthy individuals and patients, are human neural organoids, human neural transplants, and human-animal neural chimeras. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance reviews the status of research, considers its benefits and risks, discusses associated ethical issues, and considers governance mechanisms for this type of research. 517 $aEmerging Field of Human Neural Organoids, Transplants, and Chimeras 606 $aBrain$xDiseases 615 0$aBrain$xDiseases. 676 $a616.80461 701 $aAffairs$b Policy and Global$01655080 701 $aCommittee on Science$b Technology, and Law$01724000 701 $aCommittee on Ethical$b Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids$01724001 712 02$aNational Academies of Sciences, Engineering, and Medicine 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910821246003321 996 $aThe Emerging Field of Human Neural Organoids, Transplants, and Chimeras$94169101 997 $aUNINA