LEADER 02325nam 2200433 450 001 9910821014803321 005 20230807202227.0 010 $a3-8325-8782-9 035 $a(CKB)4100000010135338 035 $a(MiAaPQ)EBC6032825 035 $a5e469732-5d9c-4206-8a53-4e00b0dd2d03 035 $a(EXLCZ)994100000010135338 100 $a20200316d2015 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 13$aAn investigation of microRNA target regulation mechanisms using an integrative approach /$fvorgelegt von Ulf Schmitz 210 1$aBerlin, Germany :$cLogos Verlag,$d[2015] 210 4$dİ2015 215 $a1 online resource (xiv, 185 pages) $cillustrations 300 $a"Dissertation zur Erlangung des akademischen Grades Doktor-Ingenieur (Dr.-Ing.), Promotionsgebiet Bioinformatik Fakulta?t fu?r Informatik und Elektrotechnik Universita?t Rostok." 311 $a3-8325-4005-9 320 $aIncludes bibliographical references (pages 159-176). 330 $aLong description: This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans. 606 $aMicroRNA 606 $aRNA 615 0$aMicroRNA. 615 0$aRNA. 676 $a572.88 700 $aSchmitz$b Ulf$01695053 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910821014803321 996 $aAn investigation of microRNA target regulation mechanisms using an integrative approach$94074033 997 $aUNINA