LEADER 04956nam 2200745 a 450 001 9910820984003321 005 20240530155348.0 010 $a1-299-05153-7 010 $a1-4008-4727-3 024 7 $a10.1515/9781400847273 035 $a(CKB)2670000000330885 035 $a(EBL)1113402 035 $a(SSID)ssj0000823044 035 $a(PQKBManifestationID)12358157 035 $a(PQKBTitleCode)TC0000823044 035 $a(PQKBWorkID)10778922 035 $a(PQKB)11567721 035 $a(DE-B1597)447790 035 $a(OCoLC)827944854$z(OCoLC)828794186 035 $a(OCoLC)979758805 035 $a(DE-B1597)9781400847273 035 $a(Au-PeEL)EBL1113402 035 $a(CaPaEBR)ebr10653095 035 $a(CaONFJC)MIL436403 035 $a(OCoLC)828794186 035 $a(OCoLC)827944854 035 $a(MiAaPQ)EBC1113402 035 $a(EXLCZ)992670000000330885 100 $a20030512d2004 uy 0 101 0 $aeng 135 $aurnn#---|n||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aConsanguinity, inbreeding, and genetic drift in Italy /$fLuigi Luca Cavalli-Sforza, Antonio Moroni, and Gianna Zei 205 $aCourse Book 210 1$aPrinceton, New Jersey :$cPrinceton University Press,$dc2004. 215 $a1 online resource (329 pages) 225 0 $aMonographs in Population Biology ;$v39. 300 $aDescription based upon print version of record. 311 $a0-691-08991-4 311 $a0-691-08992-2 320 $aIncludes bibliographical references (p. [303]-311) and index. 327 $tFront matter --$tContents --$tAcknowledgments --$tCHAPTER 1. History of This Investigation and Structure of This Book --$tCHAPTER 2. Customs and Legislation Affecting Consanguineous Marriages, with Special Attention to the Catholic Church --$tCHAPTER 3. Demographic Factors Affecting the Frequencies of Consanguineous Marriage-A Study in Northern Emilia --$tCHAPTER 4. Probability of Consanguineous Marriages --$tCHAPTER 5. Consanguinity, Inbreeding, and Observed Genetic Drift in the Parma Valley --$tCHAPTER 6. A Computer Simulation of the Upper Parma Valley Population --$tCHAPTER 7. Islands --$tCHAPTER 8. Effects of Inbreeding on Normal and Pathological Phenotypes --$tCHAPTER 9. Consanguineous Marriages in Italy: Data from the Vatican Archives --$tCHAPTER 10. Geography of Demes in Italy --$tCHAPTER 11. Conclusions --$tBibliography --$tIndex --$tBackmatter 330 $aIn 1951, the geneticist Luigi Luca Cavalli-Sforza was teaching in Parma when a student--a priest named Antonio Moroni--told him about rich church records of demography and marriages between relatives. After convincing the Church to open its records, Cavalli-Sforza, Moroni, and Gianna Zei embarked on a landmark study that would last fifty years and cover all of Italy. This book assembles and analyzes the team's research for the first time. Using blood testing as well as church records, the team investigated the frequency of consanguineous marriages and its use for estimating inbreeding and studying the relations between inbreeding and drift. They tested the importance of random genetic drift by studying population structure through demography of the last three centuries, using it to predict the spatial variation of frequencies of genetic markers. The authors find that drift-related genetic variation, including its stabilization by migration, is best predicted by computer simulation. They also analyze the usefulness and limits of the concept of deme for defining Mendelian populations. The genetic effect of consanguineous marriage on recessive genetic diseases and for the detection of dominance in metric characters are also studied. Ultimately bringing together the many strands of their massive project, Cavalli-Sforza, Moroni, and Zei are able to map genetic drift in all of Italy's approximately 8,000 communes and to demonstrate the relationship between each locality's drift and various ecological and demographic factors. In terms of both methods and findings, their accomplishment is tremendously important for understanding human social structure and the genetic effects of drift and inbreeding. 410 0$aMonographs in Population Biology 606 $aConsanguinity$zItaly 606 $aInbreeding$zItaly 606 $aHuman population genetics$zItaly 606 $aHuman genetics$xVariation 615 0$aConsanguinity 615 0$aInbreeding 615 0$aHuman population genetics 615 0$aHuman genetics$xVariation. 676 $a304.6/0945 700 $aCavalli-Sforza$b L. L$g(Luigi Luca),$f1922-2018.$01737915 701 $aMoroni$b Antonio$033433 701 $aZei$b Gianna$01128460 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910820984003321 996 $aConsanguinity, inbreeding, and genetic drift in Italy$94159898 997 $aUNINA