LEADER 05145nam 2200613 450 001 9910820979003321 005 20230807213602.0 010 $a1-910190-04-7 035 $a(CKB)3710000000355112 035 $a(EBL)1977391 035 $a(SSID)ssj0001466834 035 $a(PQKBManifestationID)11831245 035 $a(PQKBTitleCode)TC0001466834 035 $a(PQKBWorkID)11504597 035 $a(PQKB)10032986 035 $a(MiAaPQ)EBC1977391 035 $a(MiAaPQ)EBC5897829 035 $a(Au-PeEL)EBL5897829 035 $a(OCoLC)904518280 035 $a(EXLCZ)993710000000355112 100 $a20191011d2015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAdvanced vaccine research $emethods for the decade of vaccines /$fedited by Fabio Bagnoli and Rino Rappuoli 210 1$aNorfolk, England :$cCaister Academic Press,$d[2015] 210 4$dİ2015 215 $a1 online resource (474 p.) 300 $aDescription based upon print version of record. 311 $a1-910190-03-9 320 $aIncludes bibliographical references and index. 327 $aContents; Contributors; Current Books of Interest; Preface; Part I: Innovative Technologies and Approaches in Vaccine Research; 1: Deep Sequencing in Vaccine Research, Development and Surveillance ; Impact of DNA sequencing on vaccines research and development; Deep sequencing potential to transform vaccinology; 2: New Bioinformatics Algorithms Applied to Deep Sequencing Projects ; Introduction; Better understating of host and pathogen genomes; Computational approaches to study adaptive immune responses; Better understanding of transcriptome 327 $aEpigenomics: understanding of inheritable chemical changesMetagenomics: finding new pathogens and strains; Bioinformatics challenges; 3: Comparative Genomics Approaches for Tracking the Emergence and Spread of Disease-associated Bacteria; Background; Comparative genomics of disease-associated bacteria; Assays for identification of disease-associated bacteria based on insights from comparative genomics; Conclusions; 4: Quantitative Proteomics in Vaccine Research; Introduction; Quantitative proteomics based on gel electrophoresis; Quantitative proteomics based on differential mass tag 327 $aLabel-free technologies and targeted proteomicsMass spectrometry for viral vaccinology; Proteomic technology for vaccine development ; Combining proteomics and system biology to improve vaccines; Concluding remarks; 5: Structural Biology in Vaccine Research; Introduction; Experimental mapping and computational prediction of epitopes; Examples of structural vaccinology for bacterial and viral pathogens; Concluding remarks and future directions; 6: Cellular Screens to Interrogate the Human T- and B-cell Repertoires and Design Better Vaccines ; Introduction 327 $aGeneration of naive B- and T-cell repertoires7: Novel Strategies of Vaccine Administration: The Science Behind Epidermal and Dermal Immunization; Introduction; The skin layers; Skin antigen-presenting cells and other players in vaccination; Principles and methods in skin immunization; Vaccine formulation and immunity; Immunological advantage of epidermal and dermal immunization; 8: Toll-like Receptors as Targets to Develop Novel Adjuvants; Introduction; Innate immunity; TLR-based adjuvants in high-priority vaccines; Lessons learned from studies of TLR agonists as adjuvants 327 $aSafety considerations of TLR agonistsChallenges for the next decade; 9: The Importance of Cell-mediated Immunity for Bacterial Vaccines ; Introduction; T-cell responses to bacterial infection; Targeting cellular immunity for novel anti-bacterial vaccine design; 10: T-cell-inducing Vaccines; Introduction; How can we measure T-cell responses?; Technologies for inducing T-cell responses by vaccination; Heterologous prime-boost immunization; Successful clinical development of T-cell vaccines; 11: Exploiting the Mutanome for Personalized Cancer Immunotherapy 327 $aCancer mutations as therapeutic targets 330 $aSince the publication of our first book book ""Vaccine Design: Innovative Approaches and Novel Strategies"" in 2011, the field of vaccinology has advanced significantly. The application of new sophisticated 'omics' technologies and the use of pioneering approaches have yielded a wealth of new data. This new book aims to distill the most important new findings to provide a timely overview of the field. Written by leading experts in the field, each chapter affords a critical insight to a particular topic, reviews current research, discusses future direction and aims to stimulate discussion. The 606 $aVaccines$xResearch 606 $aDrug development 615 0$aVaccines$xResearch. 615 0$aDrug development. 676 $a615.372 702 $aBagnoli$b Fabio 702 $aRappuoli$b Rino 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910820979003321 996 $aAdvanced vaccine research$94051163 997 $aUNINA