LEADER 03758nam 2200649 450 001 9910820913903321 005 20200520144314.0 010 $a0-12-803118-2 010 $a0-12-803117-4 035 $a(CKB)3710000000445524 035 $a(EBL)2095613 035 $a(SSID)ssj0001561554 035 $a(PQKBManifestationID)16203979 035 $a(PQKBTitleCode)TC0001561554 035 $a(PQKBWorkID)14832831 035 $a(PQKB)11558970 035 $a(MiAaPQ)EBC2095613 035 $a(Au-PeEL)EBL2095613 035 $a(CaPaEBR)ebr11079052 035 $a(CaONFJC)MIL822712 035 $a(OCoLC)914434569 035 $a(PPN)192177001 035 $a(EXLCZ)993710000000445524 100 $a20150728h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aChinmedomics $ethe integration of serum pharmacochemistry and metabolomics to elucidate the scientific value of traditional Chinese medicine /$feditor, Xijun Wang ; associate editors, Aihua Zhang, Hui Sun 210 1$aAmsterdam, [Netherlands] :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (408 p.) 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title Page; Copyright Page; Contents; List of Contributors; About the Editor; Preface; Chapter 1 - Origin of Chinmedomics; 1.1 - Introduction; 1.2 - Application and Challenges of TCM; 1.3 - Metabolomics: An Overview; 1.4 - Process of the Serum Pharmacochemistry of TCM; 1.5 - Establishment and Evolution of Chinmedomics; 1.6 - Potential Value of Chinmedomics; 1.7 - Future Perspectives; References; Chapter 2 - Methods and Protocols of Chinmedomics; 2.1 - Introduction; 2.2 - Analytical Technologies; 2.3 - Sampling; 2.4 - Data Extraction and Analysis 327 $a2.5 - Marker Identification and Validation2.6 - Correlation Analysis between Marker Metabolites and Absorbed Chemical Components; 2.7 - Goals for Chinmedomics; 2.7.1 - Biological Mechanisms of the TCM Syndrome; 2.7.2 - Pharmacological Effects of Formulae; 2.7.3 - Correlation Analysis of Formulae and Syndrome for Effective Substances; 2.8 - Chinmedomics for Yinchenhao Tang: A Case Study; 2.9 - Conclusions; References; Chapter 3 - Chinmedomics Advancing Drug Discovery and Development from Yinchenhao Tang; 3.1 - Introduction; 3.2 - Experimental Detail; 3.2.1 - Chemicals and Materials 327 $a3.3.4 - Cell Test to Verify the Therapeutic Efficacy of the Correlated Chemical Components3.4 - Conclusions; Chapter 4 - Chinmedomics Approach Dissects Therapeutic Properties of ShenQiWan Acting on ShenYangXu Syndrome; 4.1 - Introduction; 4.2 - Experimental Detail; 4.2.1 - Chemicals and Materials; 4.2.2 - Metabolomics Study; 4.2.2.1 - Animal Handling; 4.2.2.2 - Sample Collection and Preparation; 4.2.2.3 - UPLC-Q-TOF-HDMS Analysis; 4.2.2.4 - Metabolic Profiling and Metabolite Analysis; 4.2.3 - Constituents Analysis In Vitro and In Vivo; 4.2.3.1 - Animals 327 $a4.2.3.2 - Preparation of SQW Samples for Analysis 606 $aPharmaceutical chemistry 606 $aMedicine$zChina$xPhilosophy$xHistory 606 $aMedicine, Oriental$xPhilosophy$xHistory 607 $aChina$2fast 615 0$aPharmaceutical chemistry. 615 0$aMedicine$xPhilosophy$xHistory. 615 0$aMedicine, Oriental$xPhilosophy$xHistory. 676 $a615.19 702 $aWang$b Xijun 702 $aZhang$b Aihua 702 $aSun$b Hui 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910820913903321 996 $aChinmedomics$93924267 997 $aUNINA