LEADER 01159nam a22002651i 4500 001 991004183759707536 005 20031007141758.0 008 031111s1990 fr a||||||||||||||||fre 020 $a2907673025 035 $ab1253853x-39ule_inst 035 $aARCHE-057180$9ExL 040 $aDip.to Lingue$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 082 04$a849.808 245 02$aL'identité occitane :$bréflexions théoriques et expériences : actes du Colloque de Béziers (4, 5 et 6 septembre 1986) /$créunis par François Pic 260 $aMontpellier :$bSection française de l'Association Internationale d'Etudes Occitanes,$c1990 300 $a229 p. :$bill. ;$c24 cm 440 2$aL'identité occitane 650 4$aLetteratura occitana moderna 700 1 $aPic, François$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0737471 907 $a.b1253853x$b02-04-14$c13-11-03 912 $a991004183759707536 945 $aLE012 849.09 PIC$g1$i2012000155398$lle012$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i12984851$z13-11-03 996 $aIdentité occitane$91459867 997 $aUNISALENTO 998 $ale012$b13-11-03$cm$da $e-$ffre$gfr $h2$i1 LEADER 03358nam 2200637 450 001 9910149535903321 005 20200520144314.0 010 $a1-351-53103-4 010 $a1-4128-6447-X 035 $a(CKB)3710000000934010 035 $a(MiAaPQ)EBC4785137 035 $a(Au-PeEL)EBL4785137 035 $a(CaPaEBR)ebr11329482 035 $a(OCoLC)960906127 035 $a(BIP)055803198 035 $a(EXLCZ)993710000000934010 100 $a20170124h20162016 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aBook matters $ethe changing nature of literacy /$fAlan Sica 210 1$aNew Brunswick, New Jersey ;$aLondon, England :$cTransaction Publishers,$d2016. 210 4$d2016 215 $a1 online resource (283 pages) 311 $a1-4128-6502-6 320 $aIncludes bibliographical references and index. 330 8 $aScholars have been puzzling over the "future of the book" since Marshall McLuhan's famous maxim "the medium is the message" in the early 1950s. McLuhan famously argued that electronic media was creating a global village in which books would become obsolete. Such views were ahead of their time, but today they are all too relevant as declining sales, even among classic texts, have become a serious matter in academic publishing. Does anyone still read long and complex works, either from the past or the present? Is the role of a professional reader and reviewer of manuscripts still relevant? Book Matters closely analyses these questions and others. Alan Sica surmises that the concentration span required for studying and discussing complex texts has slipped away, as undergraduate classes are becoming inundated by shorter, easier-to-teach scholarly and literary works. He considers such matters in part from the point of view of a former editor of scholarly journals. In an engaging style, he gives readers succinct analyses of books and ideas that once held the interest of millions of discerning readers, such as Simone de Beavoir's Second Sex and the works of David Graham Phillips and C. Wright Mills, among others. Book Matters is not a nostalgic cry for lost ideas, but instead a stark reminder of just how aware and analytically illuminating certain scholars were prior to the Internet, and how endangered the book is in this era of pixelated communication. 606 $aBooks and reading$xHistory 606 $aIntellectual life$xHistory 606 $aLearning and scholarship$xHistory 606 $aScholarly publishing$xHistory 606 $aCriticism$xHistory 606 $aSocial sciences$xHistory 610 $aBooks And Reading 610 $aIntellectual Life 610 $aLearning And Scholarship 610 $aLiterary Criticism 610 $aHistory 610 $aEducation 615 0$aBooks and reading$xHistory. 615 0$aIntellectual life$xHistory. 615 0$aLearning and scholarship$xHistory. 615 0$aScholarly publishing$xHistory. 615 0$aCriticism$xHistory. 615 0$aSocial sciences$xHistory. 676 $a028 700 $aSica$b Alan$f1949-$0129150 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910149535903321 996 $aBook matters$93420840 997 $aUNINA LEADER 05164nam 2200625 450 001 9910820293303321 005 20230803195022.0 010 $a1-118-77637-2 010 $a1-118-77588-0 010 $a1-118-77640-2 035 $a(CKB)2670000000494070 035 $a(EBL)1574607 035 $a(SSID)ssj0001060703 035 $a(PQKBManifestationID)11695220 035 $a(PQKBTitleCode)TC0001060703 035 $a(PQKBWorkID)11087401 035 $a(PQKB)11609725 035 $a(MiAaPQ)EBC1574607 035 $a(DLC) 2013027519 035 $a(Au-PeEL)EBL1574607 035 $a(CaPaEBR)ebr10814700 035 $a(CaONFJC)MIL550381 035 $a(OCoLC)865332098 035 $a(EXLCZ)992670000000494070 100 $a20131223d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aChemistry of bioconjugates $esynthesis, characterization, and biomedical applications /$fedited by Ravin Narain 210 1$aHoboken, New Jersey :$cWiley,$d2014. 210 4$d©2014 215 $a1 online resource (495 p.) 300 $aIncludes index. 311 $a1-118-35914-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCHEMISTRY OF BIOCONJUGATES; CONTENTS; PREFACE; CONTRIBUTORS; SECTION I GENERAL METHODS OF BIOCONJUGATION; 1 COVALENT AND NONCOVALENT BIOCONJUGATION STRATEGIES; 1.1 INTRODUCTION; 1.2 COVALENT BIOCONJUGATION STRATEGIES; 1.2.1 Carboxyl Modifications; 1.2.2 Carbonyl Functional Groups; 1.2.3 Amine Modifications; 1.2.4 Thiol Modifications; 1.2.5 Hydroxyl Modifications; 1.2.6 Native Chemical Ligation and Expressed Protein Ligation; 1.2.7 Cross-linking Reagents for Bioconjugation; 1.2.8 Bioorthogonal Reactions; 1.2.9 Bioconjugation Via Transition Metal-catalyzed/Mediated Reactions 327 $a1.2.10 Other Covalent Bioconjugation Methods1.3 NONCOVALENT BIOCONJUGATION STRATEGIES; 1.3.1 Biotin-(Strept)Avidin System; 1.3.2 Electrostatic Interactions; 1.3.3 Metal-mediated Non-covalent Conjugation; 1.3.4 Hybridization Method; 1.4 CONCLUSIONS AND OUTLOOK; REFERENCES; SECTION II POLYMER BIOCONJUGATES; 2 BIOCONJUGATES BASED ON POLY(ETHYLENE GLYCOL)S AND POLYGLYCEROLS; 2.1 INTRODUCTION; 2.2 POLYETHYLENE GLYCOL-BASED BIOCONJUGATES; 2.2.1 PEG-protein Conjugates; 2.2.2 PEG-peptide Conjugates; 2.2.3 PEG-antibody Conjugates; 2.2.4 PEGylation of Cells and Tissues 327 $a2.2.5 PEG Conjugates of Oligonucleotides, Aptamers, and siRNAs2.2.6 PEG-drug Conjugates (PEG prodrugs); 2.2.7 PEGylation of Viruses; 2.3 LIMITATIONS OF PEG CONJUGATES; 2.4 POLYGLYCEROL-BASED CONJUGATES; 2.4.1 HPG-drug Conjugates; 2.4.2 HPG-peptide and Protein Conjugates; 2.4.3 HPG Glycoconjugates; 2.4.4 HPG-Red Blood Cell Conjugates for Antigen Protection; 2.5 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 SYNTHETIC POLYMER BIOCONJUGATE SYSTEMS; 3.1 INTRODUCTION; 3.2 PEPTIDE OR PROTEIN BIOCONJUGATION TECHNIQUES; 3.2.1 Conjugation with Amino Acid; 3.2.2 Conjugation with Peptide Chain 327 $a3.2.3 Conjugation with Proteins3.3 CARBOHYDRATE BIOCONJUGATION TECHNIQUES; 3.4 CONJUGATION WITH NUCLEIC ACID; 3.5 CONJUGATION WITH DRUGS; 3.6 CONJUGATION WITH CONTRAST AGENTS; 3.6.1 Polymers for Magnetic Resonance Imaging; 3.6.2 Polymers for Optical Imaging; 3.6.3 Polymers for Nuclear imaging; 3.7 CONCLUSION AND PERSPECTIVE; REFERENCES; 4 NATURAL POLYMER BIOCONJUGATE SYSTEMS; 4.1 INTRODUCTION; 4.2 NATURAL POLYMER SYSTEMS; 4.2.1 Protein-origin Polymer Bioconjugates; 4.2.2 Polysaccharidic Polymer Bioconjugates; 4.3 CONCLUSION AND FUTURE DIRECTIONS; ACKNOWLEDGMENT; REFERENCES 327 $a5 DENDRIMER BIOCONJUGATES: SYNTHESIS AND APPLICATIONS5.1 INTRODUCTION-DENDRIMERS FOR BIOCONJUGATE CHEMISTRY; 5.2 DENDRIMER-DRUG CONJUGATES; 5.2.1 Motivation for the Development of Dendrimer-Drug Conjugates; 5.2.2 Dendrimer-DOX Conjugates; 5.2.3 Dendrimer-MTX Conjugates; 5.2.4 Dendrimer-TAX Conjugates; 5.2.5 Dendrimer-NAC Conjugates; 5.2.6 Dendrimer-Sulfonic Acids; 5.3 DENDRIMER-CARBOHYDRATE CONJUGATES; 5.3.1 Motivation for the Development of Dendrimer-Carbohydrate Conjugates; 5.3.2 Dendrimer-Mannose Conjugates; 5.3.3 Dendrimer-Galactose Conjugates; 5.3.4 Dendrimer-AcNA Conjugates 327 $a5.4 DENDRIMER CONJUGATES WITH IMAGING AGENTS 330 $aThis book describes the chemistries involved in bioconjugation followed by an extensive review of all types of bioconjugates (polymers, dendrimers, nanoparticles, carbon nanotubes) reported in the literature for different bio-related applications. A section is devoted to the physico-chemical and biochemical properties of bioconjugates and implications in their uses. Finally, the book also provides a comprehensive account about the significance of bioconjugation - coverage that is lacking in many of the current resources available. 606 $aBioconjugates 615 0$aBioconjugates. 676 $a612.1/111 701 $aNarain$b Ravin$0963027 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910820293303321 996 $aChemistry of bioconjugates$94020236 997 $aUNINA