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100   $a20180331d2012      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aBiodefense research methodology and animal models /$fedited by James R. Swearengen
205   $a2nd ed.
210  1$aBoca Raton :$cCRC Press,$d2012.
215   $a1 online resource (415 p.)
300   $aDescription based upon print version of record.
311   $a1-4398-3632-9 
320   $aIncludes bibliographical references.
327   $aHistory of biological agents as weapons / James W. Martin -- Bioterrorism and biowarfare : similarities and differences / Nelson W. Rebert -- Scientific and ethical importance of animal models in biodefense research / James R. Swearengen and Arthur O. Anderson -- Development and validation of animal models / Jaime B. Anderson and Kenneth Tucker -- Infectious disease aerobiology : aerosol challenge methods / Chad J. Roy and Louise M. Pitt -- Characterization of new and advancement of existing animal models of bacillus anthracis infection / Elizabeth K. Leffel and Louise M. Pitt -- Glanders / David L. Fritz and David M. Waag -- Plague / Jeffery J. Adamovicz and Patricia L. Worsham -- Tularemia / Jeffery J. Adamovicz and David M. Waag -- Q fever / David M. Waag and David L. Fritz -- Brucellosis / Bret K. Purcell and Robert Rivard -- Alphaviruses / William D. Pratt ... [et al.] -- Orthopoxviruses / Peter B. Jahrling and Victoria Wahl-Jensen -- Animal models for viral hemorrhagic fevers / Kelly l. Warfield and Thomas W. Geisbert -- Botulinum toxins / Stephen B. Greenbaum, Jaime B. Anderson, and Frank J. Lebeda -- Ricin / Stephen B. Greenbaum and Jaime B. Anderson -- Staphylococcal and streptococcal superantigens : in vitro and in vivo assays / Teresa Krakauer and Bradley G. Stiles.
330   $aSignificant advances have been made in animal model development for biological research since the publication of the first edition of this volume, and the ramifications of the FDA's Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated with the latest research findings, Biodefense Research Methodology and Animal Models, Second Edition spans the spectrum of coverage from basic research to advanced development of medical countermeasures.Topics discussed in this volume include:A history
606   $aBioterrorism$xPrevention$xResearch
606   $aInfection$xAnimal models
606   $aCommunicable diseases$xResearch
606   $aBiological weapons
606   $aAlternative toxicity testing
606   $aToxins$xResearch
615  0$aBioterrorism$xPrevention$xResearch.
615  0$aInfection$xAnimal models.
615  0$aCommunicable diseases$xResearch.
615  0$aBiological weapons.
615  0$aAlternative toxicity testing.
615  0$aToxins$xResearch.
676   $a363.325/3
701   $aSwearengen$b James R$01675226
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910820042503321
996   $aBiodefense research methodology and animal models$94040543
997   $aUNINA