LEADER 08023nam 2200601 450 001 9910819923703321 005 20231110222605.0 010 $a1-394-26085-7 010 $a1-4051-9395-6 010 $a1-118-57419-2 035 $a(CKB)2550000001165622 035 $a(EBL)1566389 035 $a(OCoLC)864382886 035 $a(Au-PeEL)EBL1566389 035 $a(CaPaEBR)ebr10809681 035 $a(CaONFJC)MIL546890 035 $a(Au-PeEL)EBL7103824 035 $a(JP-MeL)3000110433 035 $a(MiAaPQ)EBC1566389 035 $a(EXLCZ)992550000001165622 100 $a20131210d2014 uy 0 101 0 $aeng 135 $aur|n||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe politics of European integration $epolitical union or a house divided? /$fAndrew Glencross 210 1$aChichester, England ;$aMalden, Massachusetts ;$aOxford, England :$cWiley-Blackwell,$d2014. 210 4$d2014 215 $a1 online resource (344 pages) 225 1 $aNew York Academy of Sciences 300 $aIncludes bibliographical references and index 311 $a1-4051-9394-8 311 $a1-306-15639-4 320 $aIncludes bibliographical references and index. 327 $aContents -- List of Figures -- List of Tables -- List of Timelines -- List of Boxes -- Acknowledgments -- Introduction -- The Purpose of This Book -- Why European Integration Matters -- The Basic Structure of the EU -- Plan of the Book and Learning Objectives -- Part I: The History of European Integration -- 1: The Idea of Europe: Foundations and Justifications for Unity -- 1.0 Introduction: What and Where Is Europe? -- 1.1 The Historical Background to Thinking about European Unity -- 1.2 Early Ideas and Pioneers of Unity -- 1.3 The Peace or Civilizing Justification for Unity -- 1.4 The Prosperity Justification for Unity -- 1.5 The Strengthening State Capacity Justification for Unity -- 1.6 Concluding Summary -- Guide to Further Reading -- Discussion Questions -- Web Resources -- References -- 2: The Institutional Development of European Integration, 1945-1973 -- 2.0 Introduction: Uniting for Peace -- 2.1 The Struggle to Resolve Post-War Security and Economic Issues, 1945-1951 -- 2.2 The Creation of the European Coal and Steel Community (ECSC) in 1951 -- 2.3 The Functioning of the ECSC and the Attempt at Full Military and Political Union, 1951-1957 2.4 The Continuing Pursuit of Economic Integration: Creating the EEC, 1957 -- 2.5 Overcoming the First Tests: The Common Agricultural Policy and the Empty Chair Crisis, 1957-1973 -- 2.6 Concluding Summary -- Guide to Further Reading -- Discussion Questions -- Web Resources -- References -- 3: The Institutional Development of European Integration, 1973-2010 -- 3.0 Introduction: The Widening and Deepening of European Integration -- 3.1 Living with the First Enlargement Round and Preparing for the Next, 1973-1986 3.2 Completing the Single Market as a Prelude to Monetary and Political Union, 1986-1992 -- 3.3 Designing European Unity for the Post-Cold War Era, 1992-2004 -- 3.4 From Constitutional Failure to the Lisbon Treaty, 2004-2010 -- Guide to Further Reading -- Discussion Questions -- Web Resources -- References -- 327 $aPart II: Analyzing Integration -- 4: The EU's Institutional Dynamics -- 4.0 Introduction: The Functioning of the EU -- 4.1 An Overview of the Dynamics of EU Policy-Making -- 4.2 The Ordinary Legislative Procedure (OLP) -- 4.3 The Role of Interest Groups and Experts -- 4.4 The Commission's Watchdog Role and the Importance of the CJEU -- 4.5 Special Provisions for Foreign Policy -- 4.5 Concluding Summary --5 EU Policy-Making in Action: Major EU Policies --5.0 Introduction: The EU?s Major Policy Areas --5.1 The EU Budget --5.2 The Euro --5.3 The Single Market --5.4 Social and Environmental Policy--5.5 Justice and Citizenship--5.6 Enlargement --5.7 Concluding Summary --6 The EU in Comparative Perspective --6.0 Introduction: Why Compare? --6.1 The EU Compared with Federal States --6.2 The EU Compared with International Organizations in the EU --6.3 The sui generis Interpretation --6.4 Concluding Summary -- 327 $aPART III DEBATING THE EU SYSTEM AND ITS POLICY OUTPUTS --7. EU Internal Policies:The Theory, Practice, and Politics of Regulation --7.0 Introduction: Regulatory Outputs and EU Politics --7.1 Regulatory Theory and European Integration --7.2 EU Regulation in Practice --7.3 Not Just a Regulatory State: The Politics of EU Regulatory Outputs --7.4 Theorizing EU Regulation and Explaining Its Effects --7.5 Concluding Summary --8 The Institutionalization of EU Foreign Policy and Debates over the EU?s International Role --8.0 Introduction: What Is at Stake in Understanding EU Foreign Relations? --8.1 The Institutions and Institutionalization of EU Foreign Policy --8.2 The Debate over EU Foreign Policy Effectiveness --8.3 The Ideological Debate over the Aims of EU Foreign Policy --8.4 The Explanatory Debate over EU Foreign Policy --8.5 Concluding Summary --9 What Model for Uniting Europe? --9.0 Introduction: Competing Models of European Integration --9.1 Federalism --9.2 Confederalism --9.3 The Networked Governance Model --9.4 The Differentiated Integration Model --9.5 Concluding Summary -- 327 $aPART IV DEMOCRACY AND INTEGRATION --10 Democracy in the European Union --10.0 Introduction: More Integration, More Democracy? --10.1 Democratic Accountability in the EU: Beyond Majoritarianism --10.2 The Democratic Deficit Debate --10.2.1 The procedural critique of EU democracy: A lack of responsiveness to citizens --10.2.2 The normative critique of EU democracy: The narrowing of political alternatives --10.2.3 The case against a democratic deficit --10.3 Enhancing Democracy in the EU --10.4 Concluding Summary --11 The Impact of European Integration on National Politics --11.0 Introduction: Political Adaptation to European Integration --11.1 European Integration and National Politics: The End of the Permissive Consensus --11.2 Euroskepticism and Its Varieties --11.3 National Referendums on EU Issues --11.4 Concluding Summary --12 Integration and Democracy in the Shadow of the Eurozone Debt Crisis --12.0 Introduction: The Eurozone Crisis as a Challenge to Democracy and Integration --12.1 The Causes of the Eurozone Crisis --12.2 The Travails of Formulating an EU Response --12.3 Criticism and Controversies Surrounding the EU Response --12.4 Conclusion: What the Crisis Means for the Future of Integration --Index. 330 $aThis is a systematic, up-to-date exploration of the politics of European integration that includes balanced coverage of the strengths and weaknesses of the European Union. Examines European integration as a contested political process that continues to divide and inspire nations, citizens, and politicians Provides students with the analytical tools to consider why the EU functions as it currently does, whether the EU is sufficiently democratic, the politics behind EU legislation, debates over foreign policy, proposals for institutional reform, and the Eurozone sovereign debt crisis Brings together the latest scholarly research from comparative politics, international relations, law, and democratic theory Accompanied by a range of student resources including chapter-level flashcards and independent study questions 410 0$aNew York Academy of Sciences 607 $aEuropean Union countries$xPolitics and government$y21st century 676 $a341.242/2 686 $a329.37$2njb/09 686 $a341.242/2$2njb/09 700 $aGlencross$b Andrew$0790247 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910819923703321 996 $aThe politics of European integration$94029283 997 $aUNINA LEADER 04115nam 22005655 450 001 9910992791903321 005 20250730215012.0 010 $a981-9627-63-X 024 7 $a10.1007/978-981-96-2763-9 035 $a(CKB)38165287900041 035 $a(DE-He213)978-981-96-2763-9 035 $a(MiAaPQ)EBC31979874 035 $a(Au-PeEL)EBL31979874 035 $a(EXLCZ)9938165287900041 100 $a20250328d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCell Signaling Pathways and Their Therapeutic Implication in Cancers /$fedited by Muneeb U. Rehman, Mosin Saleem Khan 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (XX, 435 p. 55 illus., 46 illus. in color.) 311 08$a981-9627-62-1 327 $aChapter 1. An Introduction to Cell Signalling pathways and their Dysregulation in cancer -- Chapter 2. Involvement of Mitogen activated protein (MAP) Kinase pathway in the etiopathogenesis of cancer and its role in cancer therapeutics -- Chapter 3. Association of PI3K/AKT/mTOR pathway with cancer and its therapeutic implications -- Chapter 4. Role and therapeutic implication of Hedgehog signalling pathway in cancer -- Chapter 5. Hippo LATS pathway in cancer and its role as a potential target for anti-cancer drugs -- Chapter 6. Role and therapeutic implication of Notch signalling pathway in cancer -- Chapter 7. Role and therapeutic implication of Wnt signalling pathway in cancer -- Chapter 8. Involvement and therapeutic implication of JAK-STAT pathway in cancer -- Chapter 9. Role of cAMP?PKA?CREB signalling pathway in cancer -- Chapter 10. Role and therapeutic implications of vitamin D signalling pathway in cancer -- Chapter 11. TGF-? signalling pathway in cancer and its therapeutic role -- Chapter 12. Role of signaling pathways regulating cell cycle progression in cancer -- Chapter 13. Role of signaling pathways regulating genomic stability in cancer. 330 $aThis book discusses different signaling pathways involved in tumor development and progression. It discusses the pathways that allow tumor cells to proliferate, survive, and invade other tissues. Further, the book reviews the signal transduction regulating phagocytosis, production of cytokines, cell division, and differentiation. It elucidates the dysregulation of cellular signal transduction induced by the genetic and epigenetic changes that drive cancer and enumerates the signaling network encompassing the extracellular matrix, blood vessels, and the immune system. Additionally, the book provides mechanistic insights into inhibitors of the receptor tyrosine kinases, BRAF, EGFR, and ALK that improve clinical response and increase the survival of patients with cancer. The book covers the signal transduction pathways that regulate cell cycle progression and genomic stability, providing a mechanistic understanding of the major checkpoint pathways, and reviewing their diagnostic and therapeutic potential. This volume is essential reading for researchers to understand the therapeutic potential of important signaling molecules against cancer. 606 $aCancer 606 $aCell division 606 $aCancer$xGenetic aspects 606 $aCancer Biology 606 $aCell Division 606 $aCancer Genetics and Genomics 615 0$aCancer. 615 0$aCell division. 615 0$aCancer$xGenetic aspects. 615 14$aCancer Biology. 615 24$aCell Division. 615 24$aCancer Genetics and Genomics. 676 $a571.978 676 $a616.994 702 $aRehman$b Muneeb U$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKhan$b Mosin Saleem$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910992791903321 996 $aCell Signaling Pathways and Their Therapeutic Implication in Cancers$94349111 997 $aUNINA