LEADER 05798nam 2200781 450 001 9910819805403321 005 20230803220228.0 010 $a1-118-41287-7 010 $a1-118-41289-3 010 $a1-118-41286-9 035 $a(CKB)2550000001127040 035 $a(EBL)1441178 035 $a(OCoLC)859836199 035 $a(SSID)ssj0001001547 035 $a(PQKBManifestationID)11551070 035 $a(PQKBTitleCode)TC0001001547 035 $a(PQKBWorkID)10966279 035 $a(PQKB)11749869 035 $a(MiAaPQ)EBC4322996 035 $a(DLC) 2013026645 035 $a(MiAaPQ)EBC1441178 035 $a(Au-PeEL)EBL1441178 035 $a(CaPaEBR)ebr10774357 035 $a(CaONFJC)MIL527704 035 $a(EXLCZ)992550000001127040 100 $a20130619d2014 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBioactive compounds from marine foods $eplant and animal sources /$fedited by Blanca Herna?ndez-Ledesma and Miguel Herrero 210 1$aChichester, West Sussex :$cJohn Wiley & Sons Inc.,$d2014. 215 $a1 online resource (467 p.) 225 0 $aIFT Press series 300 $aDescription based upon print version of record. 311 $a1-118-41284-2 311 $a1-299-96453-2 320 $aIncludes bibliographical references and index. 327 $aBioactive Compounds from Marine Foods; Contents; List of Contributors; 1 An Update on the Biomedical Prospects of Marine-derived Small Molecules with Fascinating Atom and Stereochemical Diversity; 1.1 Introduction; 1.1.1 Overview of known compounds, highlighting molecules of significance; 1.1.1.1 Clinical candidates and MDSM chemical probes; 1.1.2 Selected important marine sources of MDSMs; 1.1.2.1 Macroorganisms: an analysis of their critical role; 1.1.2.2 Microorganisms: questions about their being the actual source; 1.1.3 Highlights of MDSMs of therapeutic potential; 1.1.3.1 Terpene 327 $a1.1.3.2 Polyketide1.1.3.3 Alkaloid; 1.1.3.4 Depsipeptide; 1.1.3.5 Polyketide-peptide; 1.1.4 New insights and lessons that address supply challenges; 1.2 A view based on atom diversity; 1.2.1 Terpene; 1.2.2 Polyketide; 1.2.3 Alkaloid; 1.2.4 Depsipeptide; 1.2.5 Polyketide-peptide; 1.3 A view based on stereochemical diversity; 1.3.1 Terpene; 1.3.2 Polyketide; 1.3.3 Alkaloid; 1.3.4 Depsipeptide; 1.3.5 Polyketide-peptide; 1.4 Case studies of chemical probes and chemical probes in the therapeutic discovery pipeline; 1.5 Conclusion; Acknowledgments; References 327 $a2 Antihypertensive Peptides from Marine Sources2.1 Introduction; 2.2 Marine antihypertensive peptides and blood pressure control; 2.3 Generation of marine antihypertensive peptides; 2.4 Structure-activity relationships; 2.5 Bioavailability; 2.6 In vivo animal studies; 2.7 In vivo human studies; 2.8 Marine peptides as antihypertensive ingredients; 2.9 Conclusion; Acknowledgments; References; 3 Bioactive Peptides from Marine Processing Byproducts; 3.1 Introduction; 3.2 Fish muscle proteins: precursors of fish bioactive peptides; 3.3 Fish meal production; 3.4 Fish silage production 327 $a3.5 Traditional fermented fish protein products3.6 Strategies for the generation of bioactive peptides from marine byproducts; 3.6.1 Marine-derived peptides and human health; 3.6.1.1 Marine-derived peptides in the physiological control and maintenance of blood pressure: renin and ACE-I; 3.6.1.2 Antimicrobial peptides from marine sources and byproducts; 3.6.1.3 Antioxidant peptides from marine byproducts; 3.6.2 Membrane processing and the future for marine-derived bioactive peptide products; 3.7 Conclusion; Acknowledgments; References; 4 Development of Marine Peptides as Anticancer Agents 327 $a4.1 Introduction4.2 Peptides that induce apoptosis; 4.2.1 Peptides that activate the intrinsic mitochondrial pathway; 4.2.2 Peptides that target the JNK or p38 MAPK pathways; 4.2.3 Marine peptides that target the PI3K/AKT pathway; 4.2.4 Peptides without a known mechanism for their apoptosis-inducing activity; 4.3 Peptides that affect the tubulin-microtubule equilibrium; 4.4 Peptides that inhibit angiogenesis; 4.5 Peptides without a known mechanism for their antitumor activity; 4.6 Conclusion; Acknowledgments; References; 5 Using Marine Cryptides against Metabolic Syndrome 327 $a5.1 Marine cryptides 330 $aPart of the IFT Press series, this book reviews the myriad published information on bioactive components derived from marine foods, enabling researchers and product developers to select appropriate functional ingredients for new products. Chapters cover foods and food ingredients from both animal and plant marine sources, focusing on those which demonstrate biological properties and whose constituent compounds have been isolated and identified as potentially active. This book further addresses the biological activities of PUFAs (Polyunsaturated fatty acids), oils, phospholipids, 410 0$aIFT Press series. 606 $aPharmacognosy 606 $aMarine pharmacology 606 $aMateria medica, Vegetable 606 $aNatural products$xTherapeutic use 606 $aBioactive compounds 615 0$aPharmacognosy. 615 0$aMarine pharmacology. 615 0$aMateria medica, Vegetable. 615 0$aNatural products$xTherapeutic use. 615 0$aBioactive compounds. 676 $a615.3/21 700 $aHerna?ndez-Ledesma$b Blanca$0906315 701 $aHernandez-Ledesma$b Blanca$0906315 701 $aHerrero$b Miguel$0192857 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910819805403321 996 $aBioactive compounds from marine foods$93927235 997 $aUNINA