LEADER 05302nam 2200673Ia 450 001 9910819757903321 005 20200520144314.0 010 $a1-280-70758-5 010 $a9786610707584 010 $a0-08-046586-2 035 $a(CKB)1000000000364188 035 $a(EBL)282067 035 $a(OCoLC)437175597 035 $a(SSID)ssj0000306172 035 $a(PQKBManifestationID)12125099 035 $a(PQKBTitleCode)TC0000306172 035 $a(PQKBWorkID)10294382 035 $a(PQKB)10588668 035 $a(Au-PeEL)EBL282067 035 $a(CaPaEBR)ebr10151415 035 $a(CaONFJC)MIL70758 035 $a(OCoLC)935262660 035 $a(MiAaPQ)EBC282067 035 $a(EXLCZ)991000000000364188 100 $a20060623d2007 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPlatelets /$feditor, Alan D. Michelson 205 $a2nd ed. 210 $aAmsterdam $cElsevier Academic Press$dc2007 215 $a1 online resource (1386 p.) 300 $aDescription based upon print version of record. 311 $a0-12-369367-5 320 $aIncludes bibliographical references and index. 327 $aFront cover; PLATELETS; Copyright page; Table of contents; Contributors; Preface; Foreword: A Brief History of Ideas about Platelets in Health and Disease; Part One: Platelet Biology; CHAPTER 1: The Evolution of Mammalian Platelets; I. Introduction; II. Invertebrates; III. Nonmammalian Vertebrates; IV. Comparative Hemostasis; V. A Comparison of Human Platelets and Limulus Amebocytes; VI. The Evolution of Hemostasis and Blood Coagulation; VII. Megakaryocytes and Mammals; VIII. Conclusions; Acknowledgment; References; CHAPTER 2: Megakaryocyte Development and Platelet Formation; I. Introduction 327 $aII. Megakaryocyte Development III. Platelet Formation; IV. Regulation of Megakaryocyte Development and Platelet Formation; V. Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; References; CHAPTER 3: Platelet Structure; I. Introduction; II. Peripheral Zone; III. The Sol-Gel Zone; IV. Organelle Zone; V. Platelet Membrane Systems; References; CHAPTER 4: The Platelet Cytoskeleton; I. Introduction; II. The Structure of the Resting Platelet; III. The Cytoskeleton of the Resting Platelet; IV. The Structure of the Activated Platelet; V. Signals Activating Actin Assembly 327 $aVI. Membrane Dynamics and Actin Filament Turnover in Platelets VII. Platelet Contraction; VIII. Diseases of the Platelet Cytoskeleton; References; CHAPTER 5: Platelet Genomics and Proteomics; I. Introduction; II. Platelet Genomics; III. Platelet Proteomics; IV. Overview and Future Directions; Acknowledgment; References; CHAPTER 6: Platelet Receptors; I. Introduction; II. Integrins; III. Leucine-Rich Repeat (LRR) Family; IV. Seven Transmembrane Receptors; V. Immunoglobulin Superfamily; VI. C-Type Lectin Receptor Family; VII. Tetraspanins 327 $aVIII. Glycosyl Phosphatidylinositol (GPI)-Anchored Proteins IX. Glycosaminoglycan-Carrying Receptors; X. Tyrosine Kinase Receptors; XI. Miscellaneous Platelet Membrane Glycoproteins; Acknowledgment; References; CHAPTER 7: The Glycoprotein Ib-IX-V Complex; I. Introduction/Structure; II. Function; III. Signaling; IV. The End of the Beginning; References; CHAPTER 8: Integrin a IIbb3; I. Introduction; II. aIIbb3 as an Integrin and a Platelet Protein; III. Structure of aIIbb3; IV. "Inside-Out" Signaling and aIIbb3 Activation; V. Conclusion; References; CHAPTER 9: Thrombin Receptors 327 $aI. IntroductionII. Cellular Actions of Thrombin; III. Role of PARs in Disease; IV. Molecular and Developmental Genetics of PARs; V. Thrombin Signaling in Platelets; VI. Development of PAR Inhibitors; References; CHAPTER 10: The Platelet P2 Receptors; I. Introduction; II. Roles of Adenine Nucleotides in Platelet Function; III. P2Y1; IV. P2Y12; V. P2X1; VI. Interplay between the Platelet P2 Receptors; VII. Desensitization of the Platelet P2 Receptors; VIII. Conclusions; References; CHAPTER 11: PECAM-1; I. Introduction; II. PECAM-1 Genomic Organization and Protein Domain Structure 327 $aIII. Expression and Adhesive Properties of the Extracellular Domain 330 $aPLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. 606 $aBlood platelets 606 $aBlood platelet disorders 615 0$aBlood platelets. 615 0$aBlood platelet disorders. 676 $a611.0185 676 $a612.17 676 $a611.0185 701 $aMichelson$b Alan D$01664067 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910819757903321 996 $aPlatelets$94021903 997 $aUNINA