LEADER 05389nam 2200673Ia 450 001 9910819686203321 005 20200520144314.0 010 $a1-283-11471-2 010 $a9786613114716 010 $a0-12-381979-2 035 $a(CKB)2670000000083106 035 $a(EBL)693140 035 $a(OCoLC)729166690 035 $a(SSID)ssj0000526446 035 $a(PQKBManifestationID)11347413 035 $a(PQKBTitleCode)TC0000526446 035 $a(PQKBWorkID)10520122 035 $a(PQKB)10560161 035 $a(MiAaPQ)EBC693140 035 $a(Au-PeEL)EBL693140 035 $a(CaPaEBR)ebr10509191 035 $a(CaONFJC)MIL311471 035 $a(PPN)249764962 035 $a(EXLCZ)992670000000083106 100 $a20110811d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aVitamin D 205 $a3rd ed. /$beditor-in-chief, David Feldman ; associate editors, J. Wesley Pike, John S. Adams. 210 $aAmsterdam ;$aBoston $cElsevier/Academic Press$d2011 215 $a1 online resource (2190 p.) 300 $aDescription based upon print version of record. 311 $a0-12-381978-4 320 $aIncludes bibliographical references and index. 327 $ae9780123819789v1.pdf; Front Cover; Preface to the 3rd Edition; Chapter 92 -Control of Adaptive Immunity by Vitamin D Receptor Agonists; Chapter 95 -Vitamin D and Multiple Sclerosis; Preface to the 2nd Edition; Chapter 45 -Extrarenal 1?-Hydroxylase; Chapter 87 -The Vitamin D System and Colorectal Cancer Prevention; Introduction; Discovery of the Physiological Functions of Vitamin D; Renal Tubular Defects and Hypophosphatemia; Conclusion; Hepatic Diseases; Studies of Sun Exposure; Discovery of the Hormonal Form of Vitamin D; Histological Diagnosis of Osteomalacia; Biochemical Abnormalities 327 $aAcknowledgmentsReferences; Chapter 2 - Photobiology of Vitamin D; Historical Perspective; Chapter 4 - CYP24A1: Structure, Function, and Physiological Role; Chapter 22 - Vitamin D Regulation of Type I Collagen Expression in Bone; Chapter 83 -Vitamin D: Cancer and Differentiation; Chapter 97 -Psoriasis and Other Skin Diseases; Section XII -Therapeutic Applications and New Advances; Sunlight, Vitamin D, and Skin Cancer; Vitamin D and Other Predictors of Calcium Retention; Vitamin D Intoxication And Cardiovascular Calcification: Pharmacological Considerations; Acknowledgment; References 327 $aVitamin DChapter 3 - The Activating Enzymes of Vitamin D Metabolism (25- and 1?-Hydroxylases); General Information Regarding Vitamin D Hydroxylases; Chapter 5 - The Vitamin D Binding Protein DBP; Chapter 23 - Target Genes: Bone Proteins; Procreative Relevance - Animal Models; Vitamin D Metabolism and Mechanism of Action; Chapter 56 -Genetics of the Vitamin D Endocrine System; The Clinical Features of HVDRR; Section IX -Analogs; Overview of Hematopoiesis; Immune Activity of 1,25-Dihydroxyvitamin D; Chapter 98 -The Role of Vitamin D in Type 2 Diabetes and Hypertension 327 $aCYP24A1-Catalyzed PathwaysVitamin D Modulates Fracture Risk in Two Ways: By Increasing Bone Density and Decreasing Falls; CYP24A1: Properties, Function and Expression; Structure-Function Relationships; New World Primates; 1,25-Dihydroxyvitamin D3 Actions on Voltage-Sensitive Ca2+ Channels; Pancreatic Diseases; Perspectives; References; Vitamin D Binding Protein: Protein and Gene Structure; Properties of Mature Osteoblasts and Osteocytes; Conclusions and Perspectives; Cell-Type Specificity of Inhibition of Cell Proliferation by Vitamin D and Analogs Without Evidence of Differentiation 327 $aEconomic AspectsClosing Remarks; Future Research on Vitamin D and Respiratory/Allergic Disorders; Storage and Shipping; Vitamin D Biology; Localization and Proposed Functional Significance of the Calbindins; Idiopathic Hypercalciuria; VDR Research: The Biochemical Era; Assessment of Mineralization; Physiological and Pharmacological Actions of Vitamin D Analogs in Normal and Psoriatic Skin; VDR Research: The Molecular Biological Era; Concluding Comments; Vitamin D Amelioration of Established EAE; Acknowledgment 327 $aChapter 8 - Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital ... 330 $aVitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This 3e includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must-have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.*Most comprehensive, up-to-date two-volume set o 606 $aVitamin D 606 $aVitamins 615 0$aVitamin D. 615 0$aVitamins. 676 $a612.3/99 701 $aFeldman$b David$f1939-$01687657 701 $aPike$b J. Wesley$01687658 701 $aAdams$b John S.$cM.D.$01687659 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910819686203321 996 $aVitamin D$94061303 997 $aUNINA