LEADER 04586nam 2200793 a 450 001 9910819037703321 005 20240516065008.0 010 $a9786613694324 010 $a9781280783937 010 $a1280783931 010 $a9780470720585 010 $a0470720581 010 $a9780470718261 010 $a0470718269 035 $a(CKB)1000000000688127 035 $a(EBL)703897 035 $a(OCoLC)797918458 035 $a(SSID)ssj0000926872 035 $a(PQKBManifestationID)11559803 035 $a(PQKBTitleCode)TC0000926872 035 $a(PQKBWorkID)10899755 035 $a(PQKB)11251924 035 $a(SSID)ssj0000715467 035 $a(PQKBManifestationID)11956100 035 $a(PQKBTitleCode)TC0000715467 035 $a(PQKBWorkID)10703731 035 $a(PQKB)11525710 035 $a(MiAaPQ)EBC703897 035 $a(Au-PeEL)EBL703897 035 $a(CaPaEBR)ebr10575687 035 $a(CaONFJC)MIL369432 035 $a(Perlego)2773752 035 $a(EXLCZ)991000000000688127 100 $a19800512d1980 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProtein degradation in health and disease 205 $a1st ed. 210 1$aAmsterdam ;$aNew York :$cExcerpta Medica,$d1980. 215 $a1 online resource (430 pages) $cillustrations 225 1 $aCiba Foundation symposium ;$v75 (new ser.) 300 $aDescription based upon print version of record. 311 0 $a9780470663868 311 0 $a0470663863 311 0 $a9780444901484 311 0 $a0444901485 320 $aIncludes bibliographical references and indexes. 327 $aProtein Degradation in Health and Disease; Contents; Discussion; Introduction: the classification of proteinases; Discussion; Lysosomal cysteine proteinases; Discussion; Cathepsin D: the lysosomal aspartic proteinase; Discussion; Human leucocyte elastase and cathepsin G: structural and functional characteristics; Discussion; Human collagenases: comparative and immunolocalization studies; Discussion; Proteinases in connective tissue breakdown; Discussion; Cellular mechanisms of proteinase release from inflammatory cells and the degradation of extracellular proteins; Discussion 327 $aInactivation of cytosol enzymes by a liver membrane protein; Discussion; Lysosomes and protein degradation; Discussion; Insights into mechanisms of intracellular protein turnover from studies on pinocytosis; Discussion; Turnover and degradation of mitochondria and their proteins; Discussion; Protein degradation in cells in culture; Discussion; Regulation of protein breakdown in hepatocyte monolayers; Discussion; A possible role for neutral proteolysis in the degradation of intracellular proteins; Discussion; Studies of the ATP dependence of protein degradation in cells and cell extracts 327 $aDiscussion; Coordination of protein synthesis and degradation; Discussion; General discussion Sites of protein degradation; Application of liver perfusion as an in vitro model in studies of intracellular protein degradation; Protein degradation and the regulation of protein balance in muscle; Discussion; Protein degradation in metabolic and nutritional disorders; Discussion; Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects; Discussion; Neutral proteinases of leucocytes and the inflammatory process; Discussion; Final general discussion; Concluding remarks; Index of contributors; Subject index 330 8 $aThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. 410 0$aCiba Foundation symposium ;$vnew ser. 75. 606 $aProteins$xMetabolism$vCongresses 606 $aProteolytic enzymes$vCongresses 606 $aPhysiology, Pathological$vCongresses 615 0$aProteins$xMetabolism 615 0$aProteolytic enzymes 615 0$aPhysiology, Pathological 676 $a616.3/995 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910819037703321 996 $aProtein degradation in health and disease$92205631 997 $aUNINA