LEADER 04624nam 2200601 450 001 9910818732603321 005 20230213215339.0 010 $a1-118-79391-9 010 $a1-118-79392-7 035 $a(CKB)3280000000033630 035 $a(EBL)1887752 035 $a(SSID)ssj0000951315 035 $a(PQKBManifestationID)11603810 035 $a(PQKBTitleCode)TC0000951315 035 $a(PQKBWorkID)10893241 035 $a(PQKB)10898223 035 $a(MiAaPQ)EBC1887752 035 $a(Au-PeEL)EBL1887752 035 $a(CaPaEBR)ebr10997612 035 $a(OCoLC)894581169 035 $a(EXLCZ)993280000000033630 100 $a20150108h19831983 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aClinical trials $ea practical approach /$fStuart J. Pocock 210 1$aChichester, England :$cJohn Wiley & Sons,$d1983. 210 4$dİ1983 215 $a1 online resource (280 p.) 225 0 $aA Wiley medical publication Clinical trials 300 $aDescription based upon print version of record. 311 1 $a0-471-96883-8 311 1 $a0-471-90155-5 320 $aIncludes bibliographical references and index. 327 $aCover; Title Page; Contents; Preface; 1. Introduction: The Rationale of Clinical Trials; 1.1 Types of clinical trial; 1.2 Controlled clinical trials and the scientific method; 1.3 An example of a clinical trial for primary breast cancer; 2. The Historical Development of Clinical Trials; 2.1 Clinical trials before 1950; 2.2 Clinical trials since 1950; 2.3 Cancer chemotherapy in the United States; 2.4 Treatment of acute myocardial infarction; 2.5 The pharmaceutical industry; 3. Organization and Planning; 3.1 The protocol; 3.2 Administration, staff and finance; 3.3 Selection of patients 327 $a3.4 Treatment schedules 3.5 Evaluation of patient response; 4. The Justification for Randomized Controlled Trials; 4.1 Problems with uncontrolled trials; 4.2 Problems with historical controls; 4.3 Problems with concurrent non-randomized controls; 4.4 Is randomization feasible?; 5. Methods of Randomization; 5.1 Patient registration; 5.2 Preparing the randomization list; 5.3 Stratified randomization; 5.4 Unequal randomization; 6. Blinding and Placebos; 6.1 The justification for double-blind trials; 6.2 The conduct of double-blind trials; 6.3 When is blinding feasible?; 7. Ethical Issues 327 $a7.1 Medical progress and individual patient care 7.2 Informed patient consent; 8. Crossover Trials; 8.1 Within-patient comparisons; 8.2 The two-period crossover design; 8.3 The analysis and interpretation of crossover trials; 8.4 Multi-period crossover designs; 9. The Size of a Clinical Trial; 9.1 Statistical methods for determining trial size; 9.2 The realistic assessment of trial size; 9.3 The inadequacy of small trials; 9.4 Multi-centre trials; 9.5 The number of treatments and factorial designs; 10. Monitoring Trial Progress; 10.1 Reasons for monitoring; 10.2 Interim analyses 327 $a10.3 Repeated significance testing: group sequential designs 10.4 Continuous sequential designs; 11. Forms and Data Management; 11.1 Form design; 11.2 Data management; 11.3 The use of computers; 12. Protocol Deviations; 12.1 Ineligible patients; 12.2 Non-compliance and incomplete evaluation; 12.3 Inclusion of withdrawals in analysis; 13. Basic Principles of Statistical Analysis; 13.1 Describing the data; 13.2 Significance tests; 13.3 Estimation and confidence limits; 14. Further Aspects of Data Analysis; 14.1 Prognostic factors; 14.2 The analysis of survival data; 14.3 Multiplicity of data 327 $a15. Publication and Interpretation of Findings 15.1 Trial reports and their critical evaluation; 15.2 An excess of false-positives; 15.3 Combining evidence and overall strategy; References; Index 330 $aThis comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience. 606 $aClinical trials 615 0$aClinical trials. 676 $a615/.7/0724 700 $aPocock$b Stuart J.$0519288 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910818732603321 996 $aClinical trials$951093 997 $aUNINA LEADER 03426nam 2201057z- 450 001 9910585934703321 005 20220812 035 $a(CKB)5600000000483140 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/91198 035 $a(oapen)doab91198 035 $a(EXLCZ)995600000000483140 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNanomaterials for Ion Battery Applications 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (240 p.) 311 08$a3-0365-4770-3 311 08$a3-0365-4769-X 330 $aThis book describes recent studies in the development of nanomaterials for various secondary batteries, including Li-ion batteries (LIBs), Li-air batteries, and multivalent aqueous batteries. A simple, low-cost, and scalable synthetic process for the development of nanomaterials is another research topic in this book. The recent studies dedicated by researchers in this book highlight the importance of innovative nanostructures and new functional materials, which can open new opportunities for battery research. 606 $aPhysics$2bicssc 606 $aResearch & information: general$2bicssc 610 $aAg 610 $aAl2O3 610 $aalloy interfacial layer 610 $aaluminum-ion batteries 610 $aammonium vanadate 610 $aanode 610 $aanodes 610 $aaqueous batteries 610 $aaqueous multivalent metal-ion batteries 610 $aaqueous zinc-ion battery 610 $aaqueous Zn ion batteries 610 $aBaTiO3 610 $abifunctional activity 610 $abinary 610 $acarbon nanotubes 610 $acarbon-based composite 610 $aCe-doped LaMnO3 perovskite 610 $aCeO2 610 $acomposites 610 $acopper coating 610 $adendrite-free 610 $aelectrochemistry 610 $aelectrode materials 610 $agel polymer electrolytes 610 $ahigh rate 610 $ahydrogen evolution reaction suppression 610 $ahydrothermal method 610 $ainorganic filler 610 $aInSb 610 $aInSb-C 610 $aLi-ion batteries 610 $aLIBs 610 $alithium polymer batteries 610 $alithium-ion batteries 610 $alithium-ion battery 610 $amagnesium-ion batteries 610 $amildly acidic electrolyte 610 $aMoS2 610 $an/a 610 $ananoparticle 610 $ananosheets 610 $aPAA binder 610 $aprobe sonication 610 $aself-assembly 610 $aSiO2 610 $aSnO2 610 $aternary 610 $aTiO2 610 $atransition metal dichalcogenide 610 $auniform Zn deposition 610 $aW2C 610 $aWS2 610 $aXPS of LaMnO3 610 $azinc metal anode 610 $azinc-ion batteries 610 $aZn metal anode 610 $aZnO 610 $aZrO2 615 7$aPhysics 615 7$aResearch & information: general 700 $aHur$b Jaehyun$4edt$01314124 702 $aHur$b Jaehyun$4oth 906 $aBOOK 912 $a9910585934703321 996 $aNanomaterials for Ion Battery Applications$93031735 997 $aUNINA