LEADER 05418nam 2200673 450 001 9910818574003321 005 20230807204754.0 010 $a1-118-96062-9 010 $a1-118-96055-6 010 $a1-118-96042-4 035 $a(CKB)2670000000592465 035 $a(EBL)1895815 035 $a(SSID)ssj0001420882 035 $a(PQKBManifestationID)11805037 035 $a(PQKBTitleCode)TC0001420882 035 $a(PQKBWorkID)11422675 035 $a(PQKB)11204673 035 $a(MiAaPQ)EBC1895815 035 $a(DLC) 2014023772 035 $a(Au-PeEL)EBL1895815 035 $a(CaPaEBR)ebr11015198 035 $a(CaONFJC)MIL719003 035 $a(OCoLC)903956521 035 $a(EXLCZ)992670000000592465 100 $a20150212h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBiosynthesis of heterocycles $efrom isolation to gene cluster /$fPatrizia Diana, Girolamo Cirrincione 210 1$aHoboken, New Jersey :$cWiley,$d2015. 210 4$dİ2015 215 $a1 online resource (783 p.) 300 $a"A John Wiley & Sons, Inc., publication." 311 $a1-322-87721-1 311 $a1-118-02867-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Contents; Preface; Acknowledgments; Chapter 1 Introduction; 1.1 Natural Products: Primary and Secondary Metabolites; 1.2 Common Reactions in Secondary Metabolites; 1.2.1 Alkylations; 1.2.2 Wagner-Meerwein Rearrangements; 1.2.3 Aldol and Claisen Reactions; 1.2.4 Schiff Base Formation and Mannich Reactions; 1.2.5 Transaminations; 1.2.6 Decarboxylations; 1.2.7 Oxidation and Reduction Reactions; 1.2.8 Dehalogenation/Halogenation Reactions; 1.2.9 Glycosylation Reactions; References; Chapter 2 Techniques for Biosynthesis; 2.1 Isotopic Labeling; 2.1.1 Stable Isotopes 327 $a2.1.2 Radioactive Isotopes2.2 Gene Coding for Enzymes; 2.3 Combinatorial Biosynthesis; References; Chapter 3 Three-Membered Heterocyclic Rings and Their Fused Derivatives; 3.1 Aziridines and Azirines; 3.1.1 Azicemicins; 3.1.2 Miraziridine; 3.1.3 Maduropeptin; 3.1.4 Azinomycins; 3.1.5 Ficellomycin; 3.1.6 Mitomycins; 3.1.7 Azirinomycin and Related Azirines; 3.2 Oxiranes and Oxirenes; 3.2.1 Fosfomycin; 3.2.2 AK, HC, and AF toxins; 3.2.3 Cerulenin; 3.2.4 Polyhydroxyalkanoates; 3.2.5 Epoxyrollins; 3.2.6 Asperlactone, Aspyrone, Asperline; 3.2.7 Tajixanthone; 3.2.8 Cyclomarin; 3.2.9 Cyclopenin 327 $a3.2.10 Ovalicin and Fumagillin3.2.11 Methylenomycin A; 3.2.12 Antibiotic LL-C10037; 3.2.13 Manumycins; 3.2.14 Scopolamine; 3.2.15 Iridoid Glucosides; 3.2.16 Cordiaquinone; 3.2.17 Cyclizidine and Indolizomycin; 3.2.18 Enediyne Antibiotics; 3.2.19 Macrolides; 3.2.20 Epothilones; 3.2.21 Pimaricin; 3.2.22 Hypothemycin; 3.2.23 Radicicol and Monocillin I; 3.2.24 Trichothecenes; 3.2.25 Sporolides A and B; References; Chapter 4 Four-Membered Heterocyclic Rings and Their Fused Derivatives; 4.1 Azetidine and Azetines; 4.1.1 Azetidine-2-carboxylic acid; 4.1.2 Polyoxins; 4.1.3 Mugineic Acids 327 $a4.1.4 Tabtoxin and Tabtoxinine-?-lactam4.1.5 Nocardicins; 4.1.6 Thienamycin; 4.1.7 Clavulanic Acid and Clavams; 4.1.8 Penicillins and Cephalosporins; 4.2 Oxetanes; 4.2.1 Oxetanocins; 4.2.2 Salinosporamides; 4.2.3 Taxol; 4.3 Dithiethanes; 4.3.1 Tropodithietic acid and Thiotropocin; References; Chapter 5 Five-Membered Heterocyclic Rings and Their Fused Derivatives; 5.1 Pyrroles (Including Tetrapyrroles); 5.1.1 2-Acetyl-1-pyrroline; 5.1.2 Pyrrolnitrin; 5.1.3 Broussonetines; 5.1.4 Prodigiosin and Undecylprodigiosin; 5.1.5 Anatoxin-a and Homoanatoxin-a; 5.1.6 Nostopeptolides A 327 $a5.1.7 Pyrrolizidine Alkaloids5.1.8 Toyocamycin and Sangivamycin; 5.1.9 Tetrapyrroles; 5.2 Indoles; 5.2.1 Indole-3-acetic acid and Glucobrassicin; 5.2.2 Camalexin; 5.2.3 Cyclomarazines; 5.2.4 Rebeccamycin and Staurosporine; 5.2.5 Paxilline; 5.3 Furans; 5.3.1 Furanomycin; 5.3.2 Xenofuranones A and B; 5.3.3 Acyl ?- L-Rhamnopyranosides and Rhamnosyllactones; 5.3.4 Tuscolid and Tuscoron A and B; 5.3.5 Tetronomycin and Tetronasin; 5.3.6 Nonactin and Macrotetrolides; 5.3.7 Furanonaphthoquinone I; 5.4 Thiophenes; 5.5 Pyrazoles; 5.6 Imidazoles; 5.6.1 Histidine; 5.6.2 Amaranzole A; 5.6.3 Oroidin 327 $a5.6.4 Nikkomycins 330 $aThis book describes biosynthetic methods to synthesize heterocycliccompounds, offering a guide for the development of new drugs basedon natural products. The authors explain the role of naturalproducts in chemistry and their formation along with importantanalytical methods and techniques for working withheterocycles. Covers methods and techniques: isotopic labelling,enzymes and mutants, and pathway identification Provides a thorough resource of informationspecifically on heterocyclic natural products and their practicalbiosynthetic relevance Explains the role of natural products in chemistry a 606 $aHeterocyclic compounds$xSynthesis 606 $aBiosynthesis 615 0$aHeterocyclic compounds$xSynthesis. 615 0$aBiosynthesis. 676 $a547/.59 700 $aDiana$b Patrizia$01642348 702 $aCirrincione$b Girolamo 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910818574003321 996 $aBiosynthesis of heterocycles$93986980 997 $aUNINA