LEADER 02537nam 2200577Ia 450 001 9910818372403321 005 20200520144314.0 010 $a1-60741-670-0 035 $a(CKB)2560000000070922 035 $a(EBL)3018523 035 $a(SSID)ssj0000472797 035 $a(PQKBManifestationID)11284032 035 $a(PQKBTitleCode)TC0000472797 035 $a(PQKBWorkID)10434725 035 $a(PQKB)10722638 035 $a(MiAaPQ)EBC3018523 035 $a(EXLCZ)992560000000070922 100 $a20090228d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe ribonucleotide reductase family $egenetics and genomics /$fEduard Torrents, Margareta Sahlin and Britt-Marie Sjoberg 205 $a1st ed. 210 $aNew York $cNova Biomedical Books$dc2009 215 $a1 online resource (109 p.) 225 0 $aNovinka The ribonucleotide reductase family 300 $aDescription based upon print version of record. 311 $a1-60692-419-2 320 $aIncludes bibliographical references (p. [65]-87) and index. 327 $aIntro -- THE RIBONUCLEOTIDEREDUCTASE FAMILY:GENETICS AND GENOMICS -- Contents -- Preface -- Introduction -- RNR Classification and Occurrence -- Class I RNRs -- Class II RNRs -- Class III RNRs -- RNR distribution as seen in RNRdb -Ribonucleotide Reductase Database -- Atypical and Unconventional RNRs -- RNR Diversification -- Modularity Hypothesis for RNR ClassDiversificatio -- Regulation of RNRs -- Archaea -- Eubacteria -- Mutational Studies in RNRs -- RNR as an Antiproliferative Targetfor Disease Control -- Substrate Analogues -- Radical Scavengers Attacking the TyrosylRadical -- Iron Chelators -- Peptidomimetics Corresponding to the CTerminusof NrdB -- Manipulating the Expression of RNR -- Other Potential Inhibitors and AllostericNucleotide Analogues -- Future Antiproliferative Regimes -- Acknowledgments -- References -- Index. 606 $aOxidoreductases 606 $aEnzymes 606 $aGenetics 606 $aGenomics 615 0$aOxidoreductases. 615 0$aEnzymes. 615 0$aGenetics. 615 0$aGenomics. 676 $a572/.791 700 $aTorrents$b Eduard$01643562 701 $aSahlin$b Margareta$01643563 701 $aSjoberg$b Britt-Marie$01643564 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910818372403321 996 $aThe ribonucleotide reductase family$94190747 997 $aUNINA