LEADER 04719nam 2200697 a 450 001 9910817900703321 005 20240313133702.0 010 $a1-118-44472-8 010 $a1-299-25270-2 010 $a1-118-44477-9 010 $a1-118-44467-1 035 $a(CKB)2670000000325680 035 $a(EBL)1116228 035 $a(OCoLC)809845200 035 $a(SSID)ssj0000819694 035 $a(PQKBManifestationID)11525989 035 $a(PQKBTitleCode)TC0000819694 035 $a(PQKBWorkID)10857242 035 $a(PQKB)10752297 035 $a(MiAaPQ)EBC1116228 035 $a(DLC) 2012037064 035 $a(Au-PeEL)EBL1116228 035 $a(CaPaEBR)ebr10650976 035 $a(CaONFJC)MIL456520 035 $a(PPN)17886594X 035 $a(EXLCZ)992670000000325680 100 $a20120830d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug delivery strategies for poorly water-soluble drugs /$fedited by Dennis Douroumis and Alfred Fahr 205 $a1st ed. 210 $aChichester, West Sussex $cJohn Wiley & Sons$d2012 215 $a1 online resource (644 p.) 225 0 $aAdvances in pharmaceutical technology 300 $aDescription based upon print version of record. 311 $a0-470-71197-3 320 $aIncludes bibliographical references and index. 327 $aSelf-assembled delivery vehicles for poorly water-soluble drugs : basic theoretical considerations and modeling concepts / Silvio May and Alfred Fahr -- Liposome as intravenous solubilizers for poorly water soluble drugs / Peter van Hoogevest, Mathew Leigh and Alfred Fahr -- Drug solubilization and stabilization of cyclodextrin drug carriers / Thorsteinn Loftsson and Marcus Eli Brewster -- Solid lipid nanoparticles for drug delivery / Sonja Joseph and Heike Bunjes -- Polymeric drug delivery systems for encapsulating hydrophobic drugs / Naveed Ahmed, C.E. Mora-Heurtas, Chiraz Jaafar-Maalej, Hatem Fessi and Abdelhamid Elaissari -- Polymeric drug delivery systems for encapsulating hydrophobic drugs / Dagmar Fischer -- Development of self-emulsifying drug delivery systems (SEDDS) for oral ioavailability enhancement of poorly soluble drugs / Dimitrios G. Fatouros and Anette Mu?llertz -- Novel top-down technologies : effective production of ultra-fine drug nanocrystals / Cornelia.M. Keck, S. Kobierski, R. Mauludin and Rainer H. Mu?ller -- Nanosuspensions with enhanced drug dissolution rates of poorly water-soluble drugs / Dennis Douroumis -- Microemulsions for drug solubilization and delivery / X.Q. Wang and Qiang Zhang -- Enhancing drug solubility and bioavailability using hot melt extruded solid dispersions / Shu Li, David S. Jones and Gavin P. Andrews -- Penetration enhancers, solvents and the skin / Jonathan Hadgraft and Majella E. Lane -- Dendrimers for enhanced drug solubilization / Narendra K. Jain and Rakesh K. Tekade -- Polymeric micelles for the delivery of poorly soluble drugs / Swati Biswas, Onkar S.Vaze, Sara Movassaghian and Vladimir P. Torchilin -- Nanostructured silicon-based materials as a drug delivery system for water insoluble drugs / Vesa-Pekka Lehto, Jarno Salonen, Helder Santos and Joakim Riikonen -- Micro- and nanosizing of poorly soluble drugs by grinding techniques / Stefan Scheler -- Enhanced solubility of poorly soluble drugs via spray drying / Cordin Arpagaus, David Ru?tti and Marco Meuri. 330 $a Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development oftechniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery syst 410 0$aAdvances in Pharmaceutical Technology 606 $aDrug delivery systems 606 $aPharmaceutical chemistry 606 $aDrug carriers (Pharmacy) 606 $aSolubility 615 0$aDrug delivery systems. 615 0$aPharmaceutical chemistry. 615 0$aDrug carriers (Pharmacy) 615 0$aSolubility. 676 $a615.1 701 $aDouroumis$b Dennis$01594944 701 $aFahr$b Alfred$01594945 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910817900703321 996 $aDrug delivery strategies for poorly water-soluble drugs$93915667 997 $aUNINA