LEADER 08157nam 22015973u 450 001 9910139631203321 005 20220913225323.0 010 $a1-283-17785-4 010 $a9786613177858 010 $a1-119-97542-5 010 $a1-119-97543-3 035 $a(CKB)2550000000041124 035 $a(EBL)697595 035 $a(OCoLC)746324285 035 $a(SSID)ssj0000534944 035 $a(PQKBManifestationID)11348599 035 $a(PQKBTitleCode)TC0000534944 035 $a(PQKBWorkID)10526920 035 $a(PQKB)11302623 035 $a(MiAaPQ)EBC697595 035 $a(PPN)233220097 035 $a(EXLCZ)992550000000041124 100 $a20131014d2011|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aChemistry and Biochemistry of Oxygen Therapeutics$b[electronic resource] $eFrom Transfusion to Artificial Blood 210 $aHoboken $cWiley$d2011 215 $a1 online resource (476 p.) 300 $aDescription based upon print version of record. 311 $a0-470-68668-5 327 $aChemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References 327 $a3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis 327 $a4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway 327 $a4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction 327 $a5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma 327 $a6.2.1 Massive Transfusion 330 $aHuman blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen - the fundamental biochemical fuel - and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or "blood substitutes") which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to t 606 $aHemoglobins - therapeutic use 606 $aHemoglobins -- therapeutic use 606 $aNitric oxide - Physiological effect 606 $aNitric oxide -- Physiological effect 606 $aOxigen - Physiological effect 606 $aOxigen -- Physiological effect 606 $aOxygen - blood 606 $aOxygen -- blood 606 $aOxygen Consumption 606 $aOxygen Consumption 606 $aOxygen Inhalation Therapy - methods 606 $aOxygen Inhalation Therapy -- methods 606 $aOxygen therapy 606 $aOxygen therapy 606 $aSCIENCE / Life Sciences / Biochemistry 606 $aOxygen therapy$xPhysiological effect 606 $aOxygen$xPhysiological effect 606 $aNitric oxide 606 $aMetabolic Phenomena 606 $aRespiratory Therapy 606 $aInvestigative Techniques 606 $aBody Fluids 606 $aGlobins 606 $aChalcogens 606 $aBlood Proteins 606 $aGases 606 $aTherapeutics 606 $aFluids and Secretions 606 $aElements 606 $aHemeproteins 606 $aInorganic Chemicals 606 $aProteins 606 $aAmino Acids, Peptides, and Proteins 606 $aAnatomy 606 $aOxygen 606 $aBlood 606 $aOxygen Consumption 606 $aHemoglobins 606 $aMethods 606 $aOxygen Inhalation Therapy 606 $aHealth & Biological Sciences$2HILCC 606 $aPharmacy, Therapeutics, & Pharmacology$2HILCC 615 4$aHemoglobins - therapeutic use. 615 4$aHemoglobins -- therapeutic use. 615 4$aNitric oxide - Physiological effect. 615 4$aNitric oxide -- Physiological effect. 615 4$aOxigen - Physiological effect. 615 4$aOxigen -- Physiological effect. 615 4$aOxygen - blood. 615 4$aOxygen -- blood. 615 4$aOxygen Consumption. 615 4$aOxygen Consumption. 615 4$aOxygen Inhalation Therapy - methods. 615 4$aOxygen Inhalation Therapy -- methods. 615 4$aOxygen therapy. 615 4$aOxygen therapy. 615 4$aSCIENCE / Life Sciences / Biochemistry. 615 0$aOxygen therapy$xPhysiological effect 615 0$aOxygen$xPhysiological effect 615 0$aNitric oxide 615 2$aMetabolic Phenomena 615 2$aRespiratory Therapy 615 2$aInvestigative Techniques 615 2$aBody Fluids 615 2$aGlobins 615 2$aChalcogens 615 2$aBlood Proteins 615 2$aGases 615 2$aTherapeutics 615 2$aFluids and Secretions 615 2$aElements 615 2$aHemeproteins 615 2$aInorganic Chemicals 615 2$aProteins 615 2$aAmino Acids, Peptides, and Proteins 615 2$aAnatomy 615 2$aOxygen 615 2$aBlood 615 2$aOxygen Consumption 615 2$aHemoglobins 615 2$aMethods 615 2$aOxygen Inhalation Therapy 615 7$aHealth & Biological Sciences 615 7$aPharmacy, Therapeutics, & Pharmacology 676 $a615.8/36 676 $a615.836 686 $aSCI007000$2bisacsh 700 $aMozzarelli$b Andrea$0957272 701 $aBettati$b Stefano$0957273 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910139631203321 996 $aChemistry and Biochemistry of Oxygen Therapeutics$92168421 997 $aUNINA LEADER 03292nam 2200589 a 450 001 9910817656103321 005 20200520144314.0 010 $a1-4398-2237-9 035 $a(CKB)3400000000001333 035 $a(EBL)3001981 035 $a(SSID)ssj0000447173 035 $a(PQKBManifestationID)11250003 035 $a(PQKBTitleCode)TC0000447173 035 $a(PQKBWorkID)10525527 035 $a(PQKB)10993310 035 $a(MiAaPQ)EBC3001981 035 $a(Au-PeEL)EBL3001981 035 $a(CaPaEBR)ebr10500190 035 $a(OCoLC)763159153 035 $a(EXLCZ)993400000000001333 100 $a20041013d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCarotenoids and retinoids $emolecular aspects and health issues /$feditors, Lester Packer ... [et al.] 210 $aChampaign, Ill. $cAOCS Press$dc2005 215 $a1 online resource (359 p.) 300 $aDescription based upon print version of record. 311 $a1-893997-83-9 320 $aIncludes bibliographical references and index. 327 $a""Preface ""; ""Table of Contents ""; ""Ch 1 Introduction to Retinoids ""; ""Ch 2 Introduction to Vitamin A: A Nutritional and Life Cycle Perspective ""; ""Ch 3 The Essential Role of Vitamin A in Signal Transduction ""; ""Ch 4 Chemical and Metabolic Oxidation of Carotenoids ""; ""Ch 5 Gap Junctional Intercellular Communication: Carotenoids and Retinoids ""; ""Ch 6 Raman Detection of Carotenoids in Human Tissue ""; ""Ch 7 Macular Carotenoids in Eye Health ""; ""Ch 8 B-Carotene Cleavage Products Impair Cellular and Mitochondrial Functions and May Lead to Genotoxicity "" 327 $a""Ch 9 Formation of B-Carotene Cleavage Products in View of the Particular Conditions in Inflamed Lung Tissue """"Ch 10 Biological Activity of Lycopene Against Smoke-Induced Lung Lesions ""; ""Ch 11 Retinoids and Carotenoids as Cancer Chemopreventive Agents ""; ""Ch 12 Lycopene and Risk of Cardiovascular Disease ""; ""Ch 13 Effect of Feeding and Then Depleting a High Fruit and Vegetable Diet on Oxidizability in Human Serum ""; ""Ch 14 Mitochondria as Novel Targets for Proapoptotic Synthetic Retinoids ""; ""Ch 15 Molecular Analysis of the Vitamin A Biosynthetic Pathway "" 327 $a""Ch 16 Regulation of Transcription by Antioxidant Carotenoids """"Ch 17 Vitamin A in Health and Disease in Developing Countries ""; ""Ch 18 Lycopene and Prostate Cancer ""; ""Ch 19 Blood Response to B-Carotene Supplementation in Humans""; ""Ch 20 New Horizons in Carotenoid Research ""; ""Ch 21 Carotenoids and Cardiovascular Disease ""; ""Ch 22 Safety of B-Carotene ""; ""Index "" 606 $aCarotenoids$xHealth aspects 606 $aCarotenoids$xMolecular aspects 606 $aRetinoids$xHealth aspects 606 $aRetinoids$xMolecular aspects 615 0$aCarotenoids$xHealth aspects. 615 0$aCarotenoids$xMolecular aspects. 615 0$aRetinoids$xHealth aspects. 615 0$aRetinoids$xMolecular aspects. 676 $a612/.01528 701 $aPacker$b Lester$064927 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910817656103321 996 $aCarotenoids and retinoids$93945219 997 $aUNINA