LEADER 11043nam 2200721 a 450 001 9910817001503321 005 20200520144314.0 010 $a1-280-20370-6 010 $a9786610203703 010 $a0-309-55597-3 010 $a0-585-03433-8 035 $a(CKB)110986584751078 035 $a(OCoLC)42330229 035 $a(CaPaEBR)ebrary10062835 035 $a(SSID)ssj0000099468 035 $a(PQKBManifestationID)11108865 035 $a(PQKBTitleCode)TC0000099468 035 $a(PQKBWorkID)10007197 035 $a(PQKB)10215976 035 $a(MiAaPQ)EBC3376957 035 $a(Au-PeEL)EBL3376957 035 $a(CaPaEBR)ebr10062835 035 $a(CaONFJC)MIL20370 035 $a(OCoLC)940510409 035 $a(EXLCZ)99110986584751078 100 $a19910701d1991 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdverse effects of pertussis and rubella vaccines $ea report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines /$fChristopher P. Howson, Cynthia J. Howe, and Harvey V. Fineberg, editors 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1991 215 $a1 online resource (xii, 367 pages) $cillustrations 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a0-309-10368-1 311 0 $a0-309-04499-5 320 $aIncludes bibliographical references (p. 208-282) and index. 327 $aAdverse Effects of Pertussis and Rubella Vaccines -- Copyright -- Preface -- Acknowledgments -- Contents -- Adverse Effects of PERTUSSIS and RUBELLA Vaccines -- 1 Executive Summary -- METHODOLOGIC CONSIDERATIONS IN EVALUATING THE EVIDENCE -- SUMMARY AND CONCLUSIONS -- RESEARCH NEEDS -- 2 Histories of Pertussis and Rubella Vaccines -- PERTUSSIS VACCINES -- Epidemiology of Whooping Cough -- Clinical Description -- Diagnosis -- Complications -- Descriptive Epidemiology -- Nature of the Causative Organism, B. pertussis -- Major Milestones in the Development of Pertussis Vaccines -- Whole-Cell Vaccines -- Acellular Vaccines -- Brief History of the Controversy Pertaining to Adverse Events Following Pertussis Vaccination -- RUBELLA VACCINES -- Epidemiology of the Disease Rubella -- Clinical Description -- Diagnosis -- Complications -- Descriptive Epidemiology -- Nature of the Rubella Virus -- Major Milestones in the Development of Rubella Vaccines -- Brief History of the Controversy Pertaining to Adverse Events Following Rubella Vaccination -- REFERENCES -- 3 Methodologic Considerations in Evaluating the Evidence -- THE NATURE OF THE EVIDENCE -- QUESTIONS TO BE ADDRESSED -- (1) Can vaccine cause the adverse event? -- (2) How frequently does vaccine cause the event? -- (3) Did vaccination cause a particular case of the adverse event? -- THE BURDEN OF PROOF -- CATEGORIES OF EVIDENCE -- Experiments in Humans -- Randomized Controlled Trials -- Other Experimental Studies -- Experiments in Animals: Animal Models -- Controlled Epidemiologic Studies (Observational) -- Cohort Studies -- Case-Comparison Studies -- Other Controlled Studies -- Case Reports and Case Series -- Searching for Patterns -- Historical Comparisons -- Causation of the Individual Case -- Monitoring System for Adverse Events Following Immunization -- ASSESSMENT OF THE EVIDENCE. 327 $aEvaluation of Single Studies -- Integration of the Collective Results -- Meta-Analysis -- Considerations in Inferring Causality -- THE NATURE OF THE CONCLUSIONS -- Quantitation -- Resolution -- Uncertainty and Confidence -- Quality -- Comprehensiveness -- Neutrality -- Judgment -- SUMMARY OF THE EVIDENCE -- REFERENCES -- 4 Evidence Concerning Pertussis Vaccines and Central Nervous System Disorders, Including Infantile... -- INFANTILE SPASMS -- Clinical Description -- Descriptive Epidemiology -- History of Suspected Association with Pertussis Vaccines -- Evidence from Studies in Humans -- Case Reports and Case Series -- Controlled Epidemiologic Studies -- Summary -- Conclusion -- HYPSARRHYTHMIA -- Clinical Description -- Descriptive Epidemiology -- History of Suspected Association with Pertussis Vaccines -- Evidence from Studies in Humans -- Case Reports and Case Series -- Controlled Epidemiologic Studies -- Summary -- Conclusion -- ASEPTIC MENINGITIS -- Clinical Description -- Descriptive Epidemiology -- History of Suspected Association with Pertussis Vaccines -- Evidence from Studies in Humans -- Case Reports and Case Series -- Controlled Epidemiologic Studies -- Summary -- Conclusion -- ENCEPHALOPATHY -- Clinical Description -- Encephalopathy Following Whooping Cough -- Pathology -- Descriptive Epidemiology -- History of Suspected Association with Pertussis Vaccines -- Evidence from Studies in Humans -- Case Reports and Case Series -- Studies in Defined Populations -- The National Childhood Encephalopathy Study -- Other Controlled Studies in Humans -- Evidence from Studies in Animals -- Aluminum Salts -- Summary -- Conclusion -- REFERENCES -- 5 Evidence Concerning Pertussis Vaccines and Deaths Classified as Sudden Infant Death Syndrome -- CLINICAL DESCRIPTION, DIAGNOSIS, AND PATHOLOGY -- DESCRIPTIVE EPIDEMIOLOGY. 327 $aHISTORY OF SUSPECTED ASSOCIATION WITH PERTUSSIS VACCINES -- EVIDENCE FROM STUDIES IN HUMANS -- Case Reports and Case Series -- Controlled Epidemiologic Studies -- SUMMARY -- CONCLUSION -- REFERENCES -- 6 Evidence Concerning Pertussis Vaccines and Other Illnesses and Conditions -- ANAPHYLAXIS -- Clinical Description and Pathologic Aspects -- History of Suspected Association with Pertussis Vaccines -- Evidence from Studies in Humans -- Case Reports and Controlled Epidemiologic Studies -- Evidence from Studies in Animals -- Endotoxin -- Summary -- Conclusion -- AUTISM -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Summary -- Conclusion -- ERYTHEMA MULTIFORME OR OTHER RASH -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports -- Aluminum Salts -- Summary -- Conclusion -- GUILLAIN-BARRÉ SYNDROME (POLYNEUROPATHY) -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports -- Summary -- Conclusion -- PERIPHERAL MONONEUROPATHY -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports -- Summary -- Conclusion -- HEMOLYTIC ANEMIA -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports -- Summary -- Conclusion -- JUVENILE DIABETES -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Controlled Epidemiologic Study -- Case Report -- Evidence from Studies in Animals -- Summary -- Conclusion -- LEARNING DISABILITIES AND HYPERACTIVITY -- Clinical Description -- Learning Disability, Reading Disability, and Dyslexia -- Hyperactivity, Hyperkinesis, and Attention Deficit Disorder -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports -- Controlled Epidemiologic Studies -- Summary. 327 $aConclusion -- PROTRACTED INCONSOLABLE CRYING AND SCREAMING -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports and Case Series -- Controlled Epidemiologic Studies -- Summary -- Conclusions -- REYE SYNDROME -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Controlled Epidemiologic Study -- Case Reports and Case Series -- Summary -- Conclusion -- SHOCK AND ''UNUSUAL SHOCK-LIKE STATE" WITH HYPOTONICITY, HYPORESPONSIVENESS, AND SHORT-LIVED CONVULS ... -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports and Case Series -- Controlled Epidemiologic Studies -- Summary -- Conclusion -- THROMBOCYTOPENIA -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports and Case Series -- Summary -- Conclusion -- REFERENCES -- 7 Evidence Concerning Rubella Vaccines and Arthritis, Radiculoneuritis, and Thrombocytopenic Purpura -- ARTHRITIS -- Clinical Description and Pathologic Aspects -- Descriptive Epidemiology -- History of an Association with Rubella Vaccines -- Evidence from Studies in Humans -- Acute Arthropathy and Arthritis -- Chronic Arthritis -- Evidence from Studies in Animals -- Possible Mechanisms -- Summary -- Acute Arthropathy and Arthritis -- Chronic Arthritis -- Conclusions -- RADICULONEURITIS AND OTHER NEUROPATHIES -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports and Case Series -- Summary -- Conclusion -- THROMBOCYTOPENIC PURPURA -- Clinical Description -- Descriptive Epidemiology -- Evidence from Studies in Humans -- Case Reports -- Summary -- Conclusion -- REFERENCES -- Afterword on Research Needs -- Bibliography -- Glossary of Terms B -- Appendixes. 327 $aA Strategies For Gathering Information: Adverse Effects of Pertussis and Rubella Vaccines -- LITERATURE SEARCHES -- Electronic Data Bases -- OTHER SOURCES -- Reference Lists -- Presentations -- Public Meeting (January 10, 1990) -- Workshop (May 14, 1990) -- Committee Meeting (May 15, 1990) -- Additional Individuals and Organizations Who Provided Information -- Review of Interim Bibliography -- ABSTRACTION OF DATA FROM CASE REPORTS, CASE SERIES, AND CONTROLLED STUDIES -- Rationale -- Procedures for Abstraction and Adjudication of Study Data -- B Pertussis and Rubella Vaccines: A Brief Chronology -- PERTUSSIS VACCINES -- RUBELLA VACCINES -- REFERENCES -- C Animal Models for the Study of Whooping Cough and the Testing of Vaccine Materials -- ANIMAL MODELS FOR THE STUDY OF WHOOPING COUGH -- STANDARDIZED ANIMAL TESTS OF VACCINE MATERIALS -- REFERENCES -- D Technical Details of Power Calculations and Meta-Analyses -- POWER CALCULATIONS -- META-ANALYSES -- Formal Analysis -- Informal Analysis -- REFERENCES -- E Possible Involvement of Aluminum Salts in Erythema Multiforme, Encephalopathy, or Other Adverse E ... -- REFERENCES -- F Committee and Staff Biographies -- COMMITTEE -- STAFF -- Index. 606 $aPertussis vaccines$xSide effects$vCongresses 606 $aRubella vaccines$xSide effects$vCongresses 606 $aWhooping cough$xVaccination$xComplications$vCongresses 606 $aRubella$xVaccination$xComplications$vCongresses 615 0$aPertussis vaccines$xSide effects 615 0$aRubella vaccines$xSide effects 615 0$aWhooping cough$xVaccination$xComplications 615 0$aRubella$xVaccination$xComplications 676 $a615/.372 701 $aHowson$b Christopher Paul$01596680 701 $aHowe$b Cynthia J$01085443 701 $aFineberg$b Harvey V$01596646 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910817001503321 996 $aAdverse effects of pertussis and rubella vaccines$93973870 997 $aUNINA