LEADER 04764nam 2200661 a 450 001 9910816941903321 005 20230725052504.0 010 $a0-470-93469-7 010 $a1-283-05232-6 010 $a9786613052322 010 $a0-470-92926-X 010 $a0-470-92927-8 035 $a(CKB)3400000000000289 035 $a(EBL)675235 035 $a(OCoLC)716211010 035 $a(SSID)ssj0000477650 035 $a(PQKBManifestationID)12177170 035 $a(PQKBTitleCode)TC0000477650 035 $a(PQKBWorkID)10512391 035 $a(PQKB)10783088 035 $a(MiAaPQ)EBC675235 035 $a(Au-PeEL)EBL675235 035 $a(CaPaEBR)ebr10456208 035 $a(CaONFJC)MIL305232 035 $a(EXLCZ)993400000000000289 100 $a20100714d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMass spectrometry in drug metabolism and disposition$b[electronic resource] $ebasic principles and applications /$fedited by Mike S. Lee, Mingshe Zhu 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2011 215 $a1 online resource (776 p.) 225 0 $aWiley series on pharmaceutical science and biotechnology: practices, applications and methods 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-470-40196-6 320 $aIncludes bibliographical references and index. 327 $a(Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice -- Theory and Instrumentation of Mass Spectrometry -- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification -- Mass Spectral Interpretation -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection -- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition -- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening -- High Resolution Mass Spectrometry and Drug Metabolite Identification -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging -- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions -- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS -- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress -- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery. 330 $a"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text"--Provided by publisher. 410 0$aWiley UBCM ebooks. 410 0$aWiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods. 606 $aDrugs$xMetabolism$xAnalysis 606 $aMetabolites$xSpectra 606 $aMass spectrometry 615 0$aDrugs$xMetabolism$xAnalysis. 615 0$aMetabolites$xSpectra. 615 0$aMass spectrometry. 676 $a615/.7 701 $aLee$b Mike S.$f1960-$01593247 701 $aZhu$b Mingshe$01621377 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910816941903321 996 $aMass spectrometry in drug metabolism and disposition$94047602 997 $aUNINA