LEADER 03085nam 2200565 a 450 001 9910816724603321 005 20240410171037.0 010 $a1-61470-207-1 035 $a(CKB)2670000000149002 035 $a(EBL)3019817 035 $a(SSID)ssj0000691226 035 $a(PQKBManifestationID)12225615 035 $a(PQKBTitleCode)TC0000691226 035 $a(PQKBWorkID)10629372 035 $a(PQKB)11478296 035 $a(MiAaPQ)EBC3019817 035 $a(Au-PeEL)EBL3019817 035 $a(CaPaEBR)ebr10671382 035 $a(OCoLC)777549337 035 $a(EXLCZ)992670000000149002 100 $a20090625d2009 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMannose-binding lectin in the innate immune system$b[electronic resource] /$fIara de Messias-Reason and Angelica B.W. Boldt 205 $a1st ed. 210 $aHauppauge, N.Y. $cNova Biomedical Books$d2009 215 $a1 online resource (99 p.) 300 $aDescription based upon print version of record. 311 $a1-60692-716-7 320 $aIncludes bibliographical references and index. 327 $aIntro -- MANNOSE-BINDING LECTIN INTHE INNATE IMMUNE SYSTEM -- MANNOSE-BINDING LECTIN INTHE INNATE IMMUNE SYSTEM -- CONTENTS -- PREFACE -- INTRODUCTION -- 1. MANNOSE BINDING LECTIN (MBL)CHARACTERISTICS -- 1a. MBL2 Gene and Protein Structure -- 1b. MBL2 Transcription and Translation -- 2. MBL FUNCTIONS -- 2a. Activation of Complement -- 2b. Opsonophagocytosis -- 2c. Modulation of Inflamation -- 2d. Recognition of Altered Self and Apoptosis -- 2e. Other MBL Functions -- 3. MBL2 GENE POLYMORPHISM -- 3a. MBL2 Variants and Allelic Haplotypes -- 3b. Worldwide Distribution of MBL2 Haplotypes -- MBL2 ASSOCIATION WITH DISEASES -- 1. POSITIVE ASSOCIATION OF MBL DEFICIENCYWITH DISEASES -- 1a. Otitis Media and other Pediatric Infections -- 1b. Meningitis -- 1c. Mycoplasma Infection -- 1d. Emergent Viral Infection -- 1e. Fungal Infections -- 1f. Malaria -- 1g. Neutropenia -- 1h. Hepatitis B -- 1i. HIV Infection -- 1j. Cystic Fibrosis -- 1k. Systemic Inflammatory Response Syndrome -- 1l. Cardiovascular Diseases -- 1m. Systemic Lupus Erythematosus -- 1n. Gastrointestinal Diseases -- 2. NEGATIVE ASSOCIATION OF MBL DEFICIENCYWITH DISEASES -- 2a. Leprosy -- 2b. Tuberculosis -- 2c. Leishmaniasis -- 2d. Hepatitis C -- 2e. Rheumatic Heart Disease -- 2f. Rheumatoid Arthritis -- 2g. Ischemia/Reperfusion Injury -- 2h. Other Diseases -- 3. MBL AND HETEROZYGOTE ADVANTAGE -- 4. MBL THERAPY -- CONCLUSION -- REFERENCES -- INDEX. 606 $aLectins 606 $aNatural immunity 606 $aMannose 615 0$aLectins. 615 0$aNatural immunity. 615 0$aMannose. 676 $a616.079 700 $aDe Messias-Reason$b Iara$01695838 701 $aBoldt$b Angelica B. W$01695839 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910816724603321 996 $aMannose-binding lectin in the innate immune system$94075370 997 $aUNINA