LEADER 05534nam 2200733 450 001 9910816044503321 005 20211014220218.0 010 $a3-527-66473-4 010 $a3-527-63366-9 010 $a3-527-63365-0 035 $a(CKB)2480000000008324 035 $a(EBL)708055 035 $a(SSID)ssj0000506280 035 $a(PQKBManifestationID)11313199 035 $a(PQKBTitleCode)TC0000506280 035 $a(PQKBWorkID)10515623 035 $a(PQKB)11384149 035 $a(Au-PeEL)EBL708055 035 $a(CaPaEBR)ebr10828164 035 $a(CaONFJC)MIL568575 035 $a(MiAaPQ)EBC708055 035 $a(OCoLC)689995013 035 $a(PPN)190549211 035 $a(EXLCZ)992480000000008324 100 $a20140128d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 12$aA statistical approach to genetic epidemiology $ewith access to e-learning platform by Friedrich Pahlke /$fAndreas Ziegler and Inke R. Ko?nig 205 $aSecond edition. 210 1$aWeinheim an der Bergstrasse, Germany :$cWILEY-VCH Verlag GmbH & Co.,$d[2010]. 210 4$dİ2010 215 $a1 online resource (1011 p.) 300 $aDescription based upon print version of record. 311 1 $a3-527-32389-9 311 1 $a9783527323890 320 $aIncludes bibliographical references and index. 327 $aCover; title; Copyright; Dedication; Preface; Acknowledgments; 1: Molecular Genetics; 1.1 WHAT IS THE NATURE OF GENETIC INFORMATION?; 1.2 HOW IS GENETIC INFORMATION TRANSMITTED FROM GENERATION TO GENERATION?; 1.3 WHAT IS INDIVIDUAL VARIATION IN GENETIC INFORMATION?; 1.4 PROBLEMS; URLs; 2: Formal Genetics; 2.1 WHAT ARE MENDEL'S LAWS?; 2.2 HOW ARE PHENOTYPES TRANSMITTED IN FAMILIES?; 2.3 WHICH COMPLICATIONS TO THE GENERAL INHERITANCE PATTERNS EXIST?; 2.4 WHAT IS THE LAW DETECTED BY HARDY AND WEINBERG?; 2.5 PROBLEMS; URLs; 3: Genetic Markers; 3.1 WHAT IS A GENETIC MARKER? 327 $a3.2 WHAT TYPES OF GENETIC MARKERS ARE THERE?3.3 WHAT ARE GENOTYPING METHODS FOR SINGLE NUCLEOTIDE POLYMORPHISMS?; 3.4 PROBLEMS; URLs; 4: Data Quality; 4.1 HOW CAN PEDIGREE ERRORS BE DETECTED?; 4.2 HOW CAN GENOTYPING ERRORS BE DETECTED IN FAMILY-BASED STUDIES?; 4.3 HOW SHOULD GENOTYPING ERRORS BE CHECKED IN POPULATION-BASED STUDIES USING THE HARDY-WEINBERG EQUILIBRIUM?; Algorithm 4.1.; Algorithm 4.2.; Algorithm 4.3.; 4.4 HOW CAN GENOTYPING ERRORS BE DETECTED IN HIGH-THROUGHPUT GENOTYPING STUDIES? 327 $a4.5 HOW SHOULD CLUSTER PLOTS AND HOW CAN THE QUALITY OF CLUSTERS BE INVESTIGATED IN HIGH-THROUGHPUT GENOTYPING STUDIES?4.6 PROBLEMS; URLs; 5: Genetic Map Distances; 5.1 WHAT IS PHYSICAL DISTANCE?; 5.2 WHAT IS MAP DISTANCE?; 5.3 WHAT ARE LINKAGE DISEQUILIBRIUM UNITS?; 5.4 PROBLEMS; URLs; 6: Familiality, Heritability, and Segregation Analysis; 6.1 WHAT IS THE DIFFERENCE BETWEEN THE FAMILY HISTORY METHOD AND THE FAMILY STUDY METHOD?; 6.2 HAS THE PHENOTYPE OF INTEREST A FAMILIAL COMPONENT? WHAT ARE RECURRENCE RISK RATIOS?; 6.3 WHAT IS THE CONCEPT OF HERITABILITY? 327 $a6.4 WHAT ARE TWIN STUDIES? WHAT ARE ADOPTION STUDIES?6.5 WHAT ARE CRITICAL ASPECTS WHEN INVESTIGATING FAMILIAL RESEMBLANCE?; 6.6 HOW CAN EVIDENCE FOR A MAJOR GENE EFFECT BE ESTABLISHED? HOW CAN A SEGREGATION PATTERN FOLLOWING MENDELIAN INHERITANCE BE DETERMINED?; 6.7 PROBLEMS; URLs; 7: Model-Based Linkage Analysis; 7.1 HOW CAN THE RECOMBINATION FRACTION BE ESTIMATED BETWEEN TWO GENETIC MARKERS?; 7.2 HOW CAN THE RECOMBINATION FRACTION BE ESTIMATED BETWEEN A GENETIC MARKER AND A DISEASE?; 7.3 WHAT IS SIGNIFICANT EVIDENCE OF LINKAGE?; 7.4 PROBLEMS; URLs 327 $a8: Model-Free Linkage Analysis for Dichotomous Traits8.1 WHAT IS THE BASIC IDEA OF MODEL-FREE LINKAGE ANALYSIS?; 8.2 WHY IS AFFECTED SIB-PAIR ANALYSIS REASONABLE?; 8.3 WHAT ARE COMMON TESTS FOR AFFECTED SIB-PAIR ANALYSIS?; 8.4 IS THERE AN OPTIMAL AFFECTED SIB-PAIR TEST? ARE AFFECTED SIB-PAIR TESTS RELATED TO MODEL-BASED LINKAGE TESTS?; 8.5 HOW CAN SAMPLE SIZE OR POWER BE CALCULATED FOR AN AFFECTED SIB-PAIR STUDY?; 8.6 HOW ARE MODEL-FREE METHODS EXTENDED TO MULTIPLE MARKER LOCI?; 8.7 WHAT ARE STANDARD APPROACHES FOR THE ANALYSIS OF LARGE SIBSHIPS? 327 $a8.8 HOW CAN THE AFFECTED SIB-PAIR METHOD BE EXTENDED TO ARBITRARY UNILINEAL RELATIONSHIPS? 330 $aThis is the second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler, former President of the German Chapter of the International Biometric Society, and Inke Ko?nig, who has been teaching the subject over many years.The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes now chapters on segregation analysis, twin studies and estimation of heritability. The book is ideally suited for advanced students in epidemiology, genet 606 $aBiometria$2lemac 606 $aEpidemiologia molecular$2lemac 606 $aMolecular epidemiology 606 $aBiometry 615 7$aBiometria. 615 7$aEpidemiologia molecular 615 0$aMolecular epidemiology. 615 0$aBiometry. 676 $a614.4 700 $aZiegler$b Andreas$f1966-$0301590 701 $aKo?nig$b Inke R$0427690 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910816044503321 996 $aA statistical approach to genetic epidemiology$94008387 997 $aUNINA