LEADER 02752nam 2200589Ia 450 001 9910816000103321 005 20230617034153.0 010 $a1-281-86650-4 010 $a9786611866501 010 $a1-86094-544-9 035 $a(CKB)1000000000032775 035 $a(EBL)224807 035 $a(OCoLC)57748880 035 $a(SSID)ssj0000251020 035 $a(PQKBManifestationID)11219665 035 $a(PQKBTitleCode)TC0000251020 035 $a(PQKBWorkID)10245163 035 $a(PQKB)10105718 035 $a(MiAaPQ)EBC224807 035 $a(WSP)0000P321 035 $a(Au-PeEL)EBL224807 035 $a(CaPaEBR)ebr10082180 035 $a(EXLCZ)991000000000032775 100 $a20040609d2004 uy 0 101 0 $aeng 135 $aurcnu---unuuu 181 $ctxt 182 $cc 183 $acr 200 10$aStatistical aspects of the design and analysis of clinical trials /$fBrian S. Everitt, Andrew Pickles 205 $aRev. ed. 210 $aLondon $cImperial College Press ;$aRiver Edge, NJ $cDistributed by World Scientific Pub. Co.$d2004 215 $a1 online resource (338 p.) 300 $aDescription based upon print version of record. 311 $a1-86094-441-8 320 $aIncludes bibliographical references (p. 303-319) and index. 327 $aAn introduction to clinical trials -- Treatment allocation, the size of trials and reporting results -- Monitoring trial progress: outcome measures, compliance, dropouts and interim analyses -- Basic analyses of clinical trials, the generalized linear model and the economic evaluation of trials -- Simple approaches to the analysis of longitudinal data from clinical trials -- Multivariate normal regression models for longitudinal data from clinical trials -- Models for non-normal longitudinal data from clinical trials -- Survival analysis -- Bayesian methods longitudinal data -- Meta-analysis. 330 $aFully updated, this revised edition describes the statistical aspects of both the design and analysis of trials, with particular emphasis on the more recent methods of analysis.About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer. 606 $aClinical trials$xStatistical methods 606 $aClinical medicine$xResearch 615 0$aClinical trials$xStatistical methods. 615 0$aClinical medicine$xResearch. 676 $a615.10727 700 $aEveritt$b Brian$056108 701 $aPickles$b Andrew$01592537 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910816000103321 996 $aStatistical aspects of the design and analysis of clinical trials$93979071 997 $aUNINA