LEADER 05598nam 2200757Ia 450 001 9910814739003321 005 20240410113226.0 010 $a1-281-22736-6 010 $a9786611227364 010 $a0-08-046187-5 035 $a(CKB)1000000000357862 035 $a(EBL)270343 035 $a(OCoLC)74809798 035 $a(SSID)ssj0000252546 035 $a(PQKBManifestationID)11939291 035 $a(PQKBTitleCode)TC0000252546 035 $a(PQKBWorkID)10180790 035 $a(PQKB)10170232 035 $a(SSID)ssj0000782498 035 $a(PQKBManifestationID)12312398 035 $a(PQKBTitleCode)TC0000782498 035 $a(PQKBWorkID)10746415 035 $a(PQKB)10912460 035 $a(Au-PeEL)EBL270343 035 $a(CaPaEBR)ebr10138474 035 $a(CaONFJC)MIL122736 035 $a(MiAaPQ)EBC270343 035 $a(EXLCZ)991000000000357862 100 $a20040511d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aStructural and evolutionary genomics $enatural selection in genome evolution /$fGiorgio Bernardi 205 $a1st ed. 210 $aAmsterdam $cElsevier$d2005 215 $a1 online resource (459 p.) 225 1 $aNew comprehensive biochemistry ;$vv. 37 300 $aDescription based upon print version of record. 311 $a0-444-51255-1 311 $a0-444-52136-4 320 $aIncludes bibliographical references. 327 $aCover; PREFACE; Contents; INTRODUCTION; The genome: a short history of different views; Population genetics and molecular evolution; Three remarks on terminology; A brief chronology of our investigations; Molecular approaches to the study of the genome; LESSONS FROM A SMALL DISPENSABLE GENOME, THE MITOCHONDRIAL GENOME OF YEAST; The mitochondrial genome of yeast and the petite mutation; The ""petite colonie"" mutation; The petite mutation is accompanied by gross alterations of mitochondrial DNA; The AT spacers and the deletion hypothesis; The petite mutation is due to large deletions 327 $aThe GC clustersThe excision sites; Genomes without genes; The origins of replication; Excision and recombination; The canonical and the surrogate origins of replication of petite genomes; The replication of petite genomes and the phenomenon of suppressivity; The ori sequences as transcription initiation sites; The effect of flanking sequences on the efficiency of replication of petite genomes; The on petites 14 and 26; Temperature and the replicative ability of ori petites 14 and 26; The organization and evolution of the mitochondrial genome of yeast 327 $aThe organization of the mitochondrial genome of yeastThe evolutionary origin of ori sequences; The evolutionary origin of the GC clusters; The evolutionary origin of the AT spacers and the var 1 gene; The non-coding sequences: evolutionary origin and biological role; THE ORGANIZATION OF THE VERTEBRATE GENOME; Isochores and isochore families; The fractionation of the bovine genome; The fractionation of eukaryotic main-band DNAs; Isochores and isochore families; Isochores and the draft human genome sequence; Other misunderstandings about isochores; Compositional patterns of coding sequences 327 $aCompositional correlations between coding and non-coding sequencesTHE COMPOSITIONAL PATTERNS OF VERTEBRATE GENOMES; The fish genomes; Compositional properties: a CsCl analysis; Compositional properties: a Cs2SO4/BAMD analysis; Compositional properties: an analysis of long sequences; Compositional properties of coding sequences and introns; Compositional correlations; Amphibian genomes; Reptilian genomes; Avian genomes; Mammalian genomes; SEQUENCE DISTRIBUTION IN THE VERTEBRATE GENOMES; Gene distribution in the vertebrate genome 327 $aThe distribution of genes in the human genome: the two gene spacesProperties of the two gene spaces; The distribution of genes in the vertebrate genomes; The distribution of CpG islands in the vertebrate genome; The distribution of CpG doublets and methylation in the vertebrate genome; CpG doublets; Two different CpG levels in vertebrate genomes; Two different methylation levels in vertebrate genomes; THE DISTRIBUTION OF INTEGRATED VIRAL SEQUENCES, TRANSPOSONS AND DUPLICATED GENES IN THE MAMMALIAN GENOME; The distribution of proviruses in the mammalian genome 327 $aThe integration of retro viral sequences into the mammalian genome 330 $aStructural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subti 410 0$aNew comprehensive biochemistry ;$vv. 37. 606 $aEvolutionary genetics 606 $aGenomics 606 $aGene mapping 615 0$aEvolutionary genetics. 615 0$aGenomics. 615 0$aGene mapping. 676 $a572.8/633 700 $aBernardi$b Giorgio$069401 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910814739003321 996 $aStructural and evolutionary genomics$93945344 997 $aUNINA