LEADER 02752nam 2200445 450 001 9910814635303321 005 20230629222858.0 010 $a1-9751-4819-3 010 $a1-9751-4818-5 035 $a(CKB)4900000000505415 035 $a(MiAaPQ)EBC6561642 035 $a(Au-PeEL)EBL6561642 035 $a(OCoLC)1247677249 035 $a(EXLCZ)994900000000505415 100 $a20211116d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aOrthopaedic basic science $efoundations of clinical practice /$fedited by Roy K. Aaron 205 $aFifth edition. 210 1$aPhiladelphia :$cWolters Kluwer :$cAmerican Academy of Orthopaedic Surgeons,$d[2021] 210 4$dİ2021 215 $a1 online resource (1078 pages) 311 $a1-9751-4816-9 320 $aIncludes bibliographical references and index. 330 $a"This edition represents the scientific basis of orthopaedic surgery as of 2020. It is intended to inform clinical decision making by providing the basic sciences in a clinically relevant context. The production of the fifth edition of Orthopaedic Basic Science was a substantial undertaking contributed to by each of the authors. The author list is comprised of senior scientists and clinicians, and rising stars, a healthy mixture that reflects well on both sustained personal commitments and expectations for the future. Reflecting the growth in orthopaedic scientific information, all the previously included chapters have been revised and many new chapters have been added. Molecular biology has been refocused to emphasize the role of epigenetics. Biomaterials, repair, and tissue engineering are also emphasized. The significance of articular crosstalk is presented together with new chapters on joint biology and osteoarthritis. Consideration of gender differences in preclinical and clinical studies recognizes the spectrum of biological responses and the presentation of metabolic bone diseases acknowledges the importance of secondary fracture prevention. A completely redone section on the generation of clinical information recognizes advances in methodology, the assessment of large databases and the growth of registries, and best-practice guidelines"--$cProvided by publisher. 606 $aMusculoskeletal system$xPathophysiology 615 0$aMusculoskeletal system$xPathophysiology. 676 $a616.7075 702 $aAaron$b Roy K. 712 02$aAmerican Academy of Orthopaedic Surgeons, 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910814635303321 996 $aOrthopaedic basic science$93988648 997 $aUNINA