LEADER 03389nam 2200649 a 450 001 9910814355903321 005 20230316171339.0 010 $a1-84755-070-3 010 $a1-60119-027-1 035 $a(CKB)1000000000238269 035 $a(EBL)1185420 035 $a(SSID)ssj0000071754 035 $a(PQKBManifestationID)11107178 035 $a(PQKBTitleCode)TC0000071754 035 $a(PQKBWorkID)10091565 035 $a(PQKB)10393614 035 $a(MiAaPQ)EBC1185420 035 $a(Au-PeEL)EBL1185420 035 $a(CaPaEBR)ebr10621270 035 $a(CaONFJC)MIL871773 035 $a(OCoLC)843641090 035 $a(PPN)198475810 035 $a(EXLCZ)991000000000238269 100 $a20060105h20022002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDrug design $ecutting edge approaches /$feditor, Darren R. Flower 210 1$aCambridge :$cRoyal Society of Chemistry,$d2002. 210 4$aŠ2002 215 $a1 online resource (x, 192 pages) $cillustrations 225 1 $aSpecial publication ;$vno. 279 300 $a"Proceedings of the meeting on Cutting Edge Approaches to Drug Design held on 13 March 2001 at the Scientific Societies Lecture Theatre, London, UK"--T.p. verso. 311 0 $a0-85404-816-2 320 $aIncludes bibliographical references and index. 327 $aCONTENTS; Molecular Informatics: Sharpening Drug Design's Cutting Edge; High-Throughput X-Ray Crystallography for Drug Discovery; Trawling the Genome for G Protein-coupled Receptors: the Importance of Integrating Bioinformatic Approaches; Virtual Screening of Virtual Libraries - an Efficient Strategy for LeadGeneration; Virtual Techniques for Lead Optimisation; The Impact of Physical Organic Chemistry on the Control of Drug-likeProperties; Mutagenesis and Modelling Highlight the Critical Nature of theTM2-loop-TM3 Region of Biogenic Amine GPCRS; Computational Vaccine Design; Subject Index 330 $aPharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets.Providing details of state-of-the-art research, Drug Design: Cutting Edge Approac 410 0$aSpecial publication (Royal Society of Chemistry (Great Britain)) ;$v279. 606 $aDrugs$xDesign$vCongresses 606 $aDrugs$xDesign$xMathematical models$vCongresses 606 $aArtificial intelligence$xMedical applications$vCongresses 606 $aDrugs$xResearch$xMethodology$vCongresses 615 0$aDrugs$xDesign 615 0$aDrugs$xDesign$xMathematical models 615 0$aArtificial intelligence$xMedical applications 615 0$aDrugs$xResearch$xMethodology 676 $a615.19 701 $aFlower$b Darren R$0472707 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910814355903321 996 $aDrug design$93963642 997 $aUNINA