LEADER 05595nam 22006974a 450 001 9910814350203321 005 20200520144314.0 010 $a1-280-27707-6 010 $a9786610277070 010 $a0-470-30589-4 010 $a0-471-72877-2 010 $a0-471-72878-0 035 $a(CKB)1000000000226367 035 $a(EBL)232639 035 $a(OCoLC)475938707 035 $a(SSID)ssj0000141552 035 $a(PQKBManifestationID)11130022 035 $a(PQKBTitleCode)TC0000141552 035 $a(PQKBWorkID)10058461 035 $a(PQKB)11447511 035 $a(MiAaPQ)EBC232639 035 $a(Au-PeEL)EBL232639 035 $a(CaPaEBR)ebr10304694 035 $a(CaONFJC)MIL27707 035 $a(OCoLC)609350479 035 $a(PPN)240480988 035 $a(EXLCZ)991000000000226367 100 $a20041115d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug discovery handbook /$fedited by Shayne Cox Gad 205 $a1st ed. 210 $aHoboken, N.J. $cWiley-Interscience$dc2005 215 $a1 online resource (1493 p.) 225 1 $aPharmaceutical Development Series ;$vv.1 300 $aDescription based upon print version of record. 311 $a0-471-21384-5 320 $aIncludes bibliographical references and index. 327 $aDrug discovery in the 21st century: an introduction / Shayne C. Gad -- Natural products / Charles B. Spainhour -- Cancer cell proteomics using molecular aptamers / Weihong Tan, Zehui Cao, Dihua Shangguang -- Molecular similarity methods and QSAR models as tools for virtual screening / Jurgen Bajorath -- Systems biology: applications in drug discovery / Sean Ekins ...[et al.] -- High throughput flow cytometry / Larry A. Sklar ... [et al.] -- Combining NMR spectral information with associated structural features to form computationally non-intensive, rugged, and objective models of biological activity / Richard Beger, Dan A. Buzatu, Jon G. Wilkes -- Using Microsoft Excel as a laboratory data management tool / A. Erik Rubin, Mark F. Russo, William Neil -- The age of regulation / Sandy Weinberg, Gerald J. Whartenby -- Simultaneous screening of multiple cell lines using the CellCardtm system / Oren E. Beske -- Protein x-ray crystallography in drug discovery / Peter Nollert ...[et al.] -- Biological and chemistry assays available during drug discovery and developability assessment / Duane B. Lakings -- Strategies and methods in monitoring and targeting protein-protein interactions / Arianna Loregian, Giorgio Palu -- High throughput screening: evolution of technology and methods -- Martyn N. Banks ... [et al.] -- Metal-enhanced fluorescence: application to high-throughput screening and drug discovery / Kadir Aslan .. [et al,] -- Methods for the design and analysis of replicate-experiment studies to establish assay reproducibility and the equivalence of two potency assays / Brian J. Eastwood ... [et al.] -- Coupled luminescent methods in drug discovery: three-minute assays for cytotoxicity and phosphatase activity / Michael J. Corey, Robert J. Kinders -- Design and pharmaceutical applications of prodrugs / Tomi Jarvinen ... [et al.] -- GABA and glutamate receptor ligands and their therapeutic potential in CNS disorders / Ulf Madsen ... [et al.] -- Cardiac sarcolemmal ATP-sensitive potassium channel antagonists: novel ischemia-selective antiarrhythmic agents / George E. Billman -- Factors influencing the efficacy of mediator-specific anti-inflammatory, glucocorticoid and anti-coagulant therapies for sepsis / Peter C. Minneci ... [et al.] -- Combinatorial chemistry in the drug discovery process / Nathan T. Ross, Brian R. McNaughton, Benjamin L. Miller -- Herbal medicines and animal models of gastrointestinal diseases / C.H. Cho, J.K.S. Ko -- Endocrine and metabolic agents / Brian L. Furman -- Respiratory viruses / Paul D. Olivo -- Strategies in the design of antiviral drugs / Erik De Clercq, Piet Herdewijn -- Protein kinase inhibitors in drug discovery / Keykavous Parang, Gongqin Sun -- RNA-based therapies / Ingmar Hoerr, Steve Pascolo -- Novel imaging agents for molecular MR imaging of cancer / Dmitri Artemov, Zaver M. Bhujwalla -- Genomics-based drug discovery / Spyro Mousses -- Cancer drug discovery / Susan Mooberry. 330 $aThe Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncolo 410 0$aPharmaceutical Development Series 606 $aDrugs$xResearch$vHandbooks, manuals, etc 606 $aDrug development$vHandbooks, manuals, etc 606 $aDrugs$xDesign$vHandbooks, manuals, etc 606 $aPharmaceutical chemistry$vHandbooks, manuals, etc 615 0$aDrugs$xResearch 615 0$aDrug development 615 0$aDrugs$xDesign 615 0$aPharmaceutical chemistry 676 $a615/.19 701 $aGad$b Shayne C.$f1948-$096171 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910814350203321 996 $aDrug discovery handbook$93963601 997 $aUNINA